Genetic basis for individual variations in pain perception and the development of a chronic pain condition

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

1995 • 1,152 citations

COMT val ¹⁵⁸ met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor

2003 • 1,103 citations

Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.

1999 • 1,029 citations

Complex promoter and coding region β ₂ -adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

2000 • 971 citations

Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor

2003 • 887 citations

Nociception from skeletal muscle in relation to clinical muscle pain

1993 • 833 citations

Method for quantitative estimation of thermal thresholds in patients.

1976 • 777 citations

A Highly Significant Association between a COMT Haplotype and Schizophrenia

2002 • 701 citations

Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses

1977 • 583 citations

The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

2003 • 509 citations

The genetic mediation of individual differences in sensitivity to pain and its inhibition

1999 • 435 citations

The nature and identification of quantitative trait loci: a community's view

2003 • 426 citations

Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain

1995 • 370 citations

Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: evidence for altered temporal summation of pain

1998 • 367 citations

Congenital insensitivity to pain: an update

2003 • 352 citations

Association Between a Functional Catechol O-Methyltransferase Gene Polymorphism and Schizophrenia: Meta-Analysis of Case-Control and Family-Based Studies

2003 • 348 citations

First onset of common pain symptoms: a prospective study of depression as a risk factor

1993 • 345 citations

A Haplotype Implicated in Schizophrenia Susceptibility Is Associated with Reduced COMT Expression in Human Brain

2003 • 340 citations

Characterization and Implications of Estrogenic Down-Regulation of Human Catechol-O-Methyltransferase Gene Transcription

1999 • 297 citations

Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia.

1994 • 289 citations

Characteristics of Temporal Summation of Second Pain Sensations Elicited by Brief Contact of Glabrous Skin by a Preheated Thermode

1997 • 257 citations

A Novel Method for SNP Detection Using a New Duplex-Specific Nuclease From Crab Hepatopancreas

2002 • 242 citations

Temporomandibular disorders and related pain conditions

1997 • 199 citations

Quantification of changes in myofascial trigger point sensitivity with the pressure algometer following passive stretch

1986 • 178 citations

Widespread pain as a risk factor for dysfunctional temporomandibular disorder pain

2003 • 167 citations

Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11

2000 • 142 citations

Vagal modulation of nociception is mediated by adrenomedullary epinephrine in the rat

2003 • 97 citations

Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation

2002 • 83 citations

Meta‐analysis of the association between the catecholamine‐O‐methyl‐transferase gene and obsessive‐compulsive disorder

2003 • 77 citations

Technologies for detecting genetic polymorphisms in pharmacogenomics

1999 • 76 citations

Research suggests importance of haplotypes over SNPs

2000 • 61 citations

The effects of intracerebroventricular injection of naloxone, phentolamine and methysergide on the transmission of nociceptive signals in rat dorsal horn neurons with convergent cutaneous-deep input

1991 • 45 citations

Erythrocyte Catechol-O-Methyltransferase Activity in Facial Pain Patients

1976 • 39 citations

Assay of Catechol-O-Methyltransferase Activity in Human Erythrocytes Using Norepinephrine as a Natural Substrate

2002 • 25 citations

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