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The role of the basal ganglia in nociception and pain

Data up to Jan 2025

Published1995
Citations600
References398

Total Citations Per Year

Abstract

References (398)

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Reduced pain-related behavior by adrenal medullary transplants in rats with experimental painful peripheral neuropathy

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Processing of somatosensory information in striatum of behaving cats.

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1988 • 92 citations

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1982 • 91 citations

Depression and Parkinson's disease.

1987 • 90 citations

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1988 • 90 citations

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Increased levels of Met-enkephalin-like immunoreactivity in the spinal cord CSF of rats with adrenal medullary transplants

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Spatial relationships of axons arising from the substantia nigra, spinal trigeminal nucleus, and pedunculopontine tegmental nucleus within the intermediate gray of the cat superior colliculus

1991 • 87 citations

Pharmacological analysis of analgesia and self-stimulation elicited by electrical stimulation of catecholamine nuclei in the rat brain

1978 • 87 citations

Parkinson's disease affects differently Met5- and Leu5-enkephalin in the human brain

1983 • 87 citations

Function of the Basal Ganglia as Revealed by Cognitive and Motor Disorders in Parkinson’s Disease

1984 • 87 citations

Subcortical projections to the centromedian and parafascicular thalamic nuclei in the cat

1991 • 86 citations

Neuropeptides in the basal ganglia.

1986 • 83 citations

The effect of local and systemic application of dopaminergic agents on tail flick latency in the rat

1985 • 83 citations

Ascending catecholamine systems and morphine analgesia

1975 • 83 citations

Pain in Parkinsonʼs disease

1985 • 82 citations

Anesthetic influences on the basal acticity and pharmacological responsiveness of nigrostriatal dopamine neurons

1990 • 80 citations

Nociceptive responses in the neostriatum and globus pallidus of the anesthetized rat

1993 • 80 citations

The representation of prolonged and intense, noxious somatic and visceral stimuli in the ventrolateral orbital cortex of the cat

1992 • 79 citations

Modulation of dopamine release in rat striatal slices by delta opiate agonists.

1982 • 79 citations

Nociceptive neurons in rat superior colliculus: response properties, topography, and functional implications

1989 • 78 citations

Noxious stimuli excite neurons in nucleus submedius of the normal and arthritic rat

1988 • 77 citations

Basal ganglia —input, neural activity, and relation to the cortex

1991 • 76 citations

Ascending afferent regulation of rat midbrain dopamine neurons

1993 • 76 citations

D2 dopamine receptor involvement in spinal dopamine-produced antinociception

1992 • 76 citations

Dopaminergic and non-dopaminergic projections to amygdala from substantia nigra and ventral tegmental area

1983 • 76 citations

Topographical projections from the posterior thalamic regions to the striatum in the cat, with reference to possible tecto-thalamo-striatal connections

1985 • 75 citations

Frequency and Cause of Parkinson’s Disease

1992 • 75 citations

Chloral hydrate anesthesia alters the responsiveness of identified midbrain dopamine neurons to dopamine agonist administration

1989 • 74 citations

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1987 • 74 citations

The afferent projections to the centrum medianum of the cat as demonstrated by retrograde transport of horseradish peroxidase

1980 • 72 citations

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1977 • 71 citations

Pain threshold alterations by brain stimulation in the monkey

1971 • 71 citations

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1966 • 70 citations

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1979 • 69 citations

Defective Utilization of Sensory Input as the Basis for Bradykinesia, Rigidity and Decreased Movement Repertoire in Parkinson’s Disease: A Hypothesis

1984 • 68 citations

Responses of Neurons in the Rat Nucleus Submedius to Noxious and Innocuous Mechanical Cutaneous Stimulation

1989 • 68 citations

The globus pallidus receives a projection from the parafascicular nucleus in the rat

1991 • 67 citations

Dopaminergic effects on tail-flick response in spinal rats

1982 • 67 citations

Superior colliculus cells respond to noxious stimuli

1978 • 66 citations

Opposing effects of apomorphine on pain in rats. Evaluation of the dose-response curve

1983 • 63 citations

Elevation of aversive threshold in rats by intra-amygdaloid injection of morphine sulphate

1977 • 62 citations

Dopamine in the lateral caudate-putamen of the rat is essential for somatosensory orientation.

1986 • 62 citations

The Adrenal Medullary Transplant Operation for Park in son's Disease : Clinical Observations in Five Patients

1988 • 61 citations

Diencephalic and mesencephalic efferents of the medial prefrontal cortex in the rat: Electrophysiological evidence for the existence of branched axons

1983 • 60 citations

Afferent fibers to the cingular vocalization region in the squirrel monkey

1983 • 59 citations

Topographical organization of efferent projections from the cat substantia nigra pars reticulata

1988 • 59 citations

Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways

1980 • 58 citations

β‐Endorphin cerebrospinal fluid decrease in untreated parkinsonian patients

1985 • 58 citations

Effects of peripheral stimulation on the activity of neurons in the ventral tegmental area, substantia nigra and midbrain reticular formation of rats

1982 • 58 citations

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1987 • 58 citations

Sensory‐motor processing in substantia nigra pars reticulata in conscious cats.

1984 • 58 citations

Inhibitory effects of substantia nigra on impulse transmission from nociceptors

1979 • 57 citations

Influence of 6-hydroxydopamine on the effect of morphine on the tail-flick latency

1973 • 57 citations

Opiate receptor binding in rhesus monkey brain: association with limbic structures

1978 • 57 citations

Effects of cholinergic and dopaminergic agents on pain and morphine analgesia measured by three pain tests

1983 • 57 citations

Relationships among pain, depression, and sleep alterations in Parkinson's disease.

1987 • 54 citations

Responses of substantia nigra neurones to noxious stimulation

1979 • 54 citations

Basal ganglia and cerebellum receive different somatosensory information in rats.

1990 • 54 citations

Hyperperfusion of Cerebral Cortex, Thalamus and Basal Ganglia During Spontaneously Occurring Migraine Headaches

1989 • 54 citations

Responses of neurons in the rat ventrolateral orbital cortex to phasic and tonic nociceptive stimulation

1991 • 53 citations

Forebrain sites differentially sensitive to beta-endorphin and morphine for analgesia and release of Met-enkephalin in the pentobarbital-anesthesized rat.

1992 • 52 citations

Neurotransmitters in the human and nonhuman primate basal ganglia.

1986 • 52 citations

Thermoreceptive lamina I trigeminothalamic neurons project to the nucleus submedius in the cat

1991 • 52 citations

Intensity-dependent nociceptive responses from presumed dopaminergic neurons of the substantia nigra, pars compacta in the rat and their modification by lateral habenula inputs

1990 • 51 citations

Responses of striatal neurons to peripheral sensory stimulation in symptomatic MPTP-exposed cats

1991 • 51 citations

Persistent denial of handicap after infarction of the right basal ganglia: a case study.

1988 • 51 citations

Subarachnoid spinal cord transplantation of adrenal medulla suppresses chronic neuropathic pain behavior in rats

1990 • 51 citations

A Sustained-Release Formulation of L-Dopa (Madopar HBS) in the Treatment of Nocturnal and Early-Morning Disabilities in Parkinson’s Disease

1987 • 50 citations

Dopamine in the lateral caudate-putamen of the rat is essential for somatosensory orientation.

1986 • 50 citations

Sensory responses of intralaminar thalamic neurons activated by the superior colliculus

1992 • 50 citations

Evidence that the substantia nigra is a component of the endogenous pain suppression system in the rat

1988 • 48 citations

Regional distribution of met-enkephalin within the amygdaloid complex and bed nucleus of the stria terminals

1978 • 48 citations

Efferent projections from the external parabrachial area to the forebrain: a Phaseolus Vulgaris leucoagglutinin study in the rat

1991 • 48 citations

Inhibition of neuronal activity of the substantia nigra by noxious stimuli and its modification by the caudate nucleus

1980 • 48 citations

The effect of substantia nigra stimulation and morphine on α-motoneurones and the tail-flick response

1978 • 47 citations

Comparative distribution of neurokinin B-, substance P- and enkephalin-like immunoreactivities and neurokinin B messenger RNA in the basal forebrain of the rat: Evidence for neurochemical compartmentation

1992 • 46 citations

Response of caudate neurons to stimulation of intrinsic and peripheral afferents in normal, symptomatic, and recovered MPTP-treated cats

1993 • 46 citations

The basal ganglia and the initiation of movement.

1990 • 46 citations

Response properties of nociceptive and low-threshold mechanoreceptive neurons in the hamster superior colliculus

1987 • 45 citations

Role of Basal Ganglia in Control of Innate Movements, Learned Behavior and Cognition—A Hypothesis

1994 • 45 citations

Electrophysiological evidence for a somatotopic sensory projection to the striatum of the rat

1982 • 44 citations

Electrophysiological changes in substantia nigra after dynorphin administration

1986 • 43 citations

Disappearance of phantom pain after focal brain infarction

1988 • 43 citations

Pallidal and entopeduncular single unit activity in cats during drinking

1975 • 42 citations

Amitriptyline in the treatment of headache in patients with Parkinson's disease

1988 • 42 citations

Neuronal responses to noxious stimulation in rat somatosensory cortex

1982 • 42 citations

Afferent connections of the rat substantia nigra pars lateralis with special reference to peptide-containing neurons of the amygdalo-nigral pathway

1992 • 42 citations

Levodopa and Induced-Pain Response

1973 • 42 citations

Substantia nigra unit responses to trigeminal sensory stimulation

1979 • 42 citations

Different localizations of met-enkephalin-like immunoreactivity in rat forebrain and spinal cord using hydrogen peroxide and Triton X-100. Light microscopic study

1983 • 42 citations

Substance P-positive thalamocaudate neurons in the center median-parafascicular complex in the cat

1984 • 41 citations

Direct projections from the central amygdaloid nucleus to the globus pallidus and substantia nigra in the cat

1992 • 41 citations

L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses.

1992 • 40 citations

Dopaminergic modulation of sensory responses of striatal neurons: single unit studies

1985 • 39 citations

The 'marginal division': a new subdivision in the neostriatum of the rat.

1988 • 38 citations

Interactions between the basal ganglia, the pontine parabrachial region, and the trigeminal system in cat

1986 • 37 citations

The Symptoms of Patients Treated for Parkinsonʼs Disease

1985 • 37 citations

Painful dystonic spasms in Parkinson's disease.

1984 • 37 citations

A Study of the Connections of Nociceptive Substantia Nigra Neurones

1982 • 37 citations

Mesocortical dopaminergic neurons. 1. Electrophysiological properties and evidence for soma-dendritic autoreceptors

1989 • 37 citations

Recovery of function and basal ganglia [14C]2-deoxyglucose uptake after nigrostriatal injury

1983 • 36 citations

Effect of selective opiate antagonists on striatal acetylcholine and dopamine release

1992 • 36 citations

Post-traumatic basal ganglia hemorrhage: analysis of 52 patients with emphasis on the final outcome.

1991 • 36 citations

Value and appropriate use of rating scales and apparative measurements in quantification of disability in Parkinson's disease

1993 • 36 citations

Somatosensory properties of globus pallidus neurons in awake cats

1982 • 36 citations

Motor and nonmotor behavioral deficits in monkeys made hemiparkinsonian by intracarotid MPTP infusion

1992 • 36 citations

Bilateral intranigral microinjection of morphine and opioid peptides produces antinociception in rats

1987 • 36 citations

Endogenous opiate response to pain in rheumatoid arthritis and cortical and subcortical response to pain in normal volunteers using positron emission tomography.

1991 • 35 citations

Acute ipsilateral hyperalgesia and chronic contralateral hypoalgesia after unilateral 6-hydroxydopamine lesions of the substantia nigra

1986 • 35 citations

Origin, course and termination of dopaminergic substantia nigra neurons projecting to the amygdaloid complex in the cat

1981 • 35 citations

Widespread dopaminergic projections of the subparafascicular thalamic nucleus in the rat

1993 • 35 citations

Neuropsychological effects of brain autograft of adrenal medullary tissue for the treatment of Parkinson's disease

1988 • 35 citations

Acute and Long Term Effects of 1‐Methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP) in Tests of Nociception in Mice

1992 • 35 citations

The effect of thalamic nucleus submedius lesions on nociceptive responding in rats

1994 • 34 citations

Response properties of the perioral reflex in parkinson's disease

1987 • 34 citations

Peripheral excitatory input to substantia nigra

1978 • 34 citations

Pain and Sensory Symptoms in Parkinson's Disease

1988 • 34 citations

Analgesic Action of Methylphenidate on Parkinsonian Sensory Symptoms

1988 • 34 citations

Evidence for the Role of Spinal Cord Systems in Parkinsonʼs Disease-Associated Pain

1990 • 33 citations

Involvement of the midbrain reticular formation in self-injurious behavior, stereotyped behavior, and analgesia induced by intranigral microinjection of muscimol

1986 • 33 citations

Effects of iontophoretic etorphine and naloxone, and electroacupuncture on nociceptive responses from thalamic neurones in rabbits

1991 • 32 citations

Collateral projection from the substantia nigra to the striatum and superior colliculus in the rat

1988 • 32 citations

Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?

1986 • 31 citations

Current concepts in Parkinson's disease research

1995 • 31 citations

The Threshold of Pain and Neurotransmitter's Change on Pain in Parkinson's Disease

1990 • 31 citations

High density of zinc-containing and dynorphin B- and substance P-immunoreactive terminals in the marginal division of the rat striatum

1990 • 30 citations

Dissociative anesthesia and striatal neuronal electrophysiology

1991 • 30 citations

Intravenous morphine depresses the transmission of noxious messages to the nucleus centralis of the amygdala

1993 • 30 citations

Effect of superior colliculus lesions on sensory unit responses in the intralaminar thalamus of the rat

1992 • 29 citations

Opioid peptides in Parkinson's disease: effects of dopamine repletion

1991 • 28 citations

Somatosensory neurons projecting from the superior colliculus to the intralaminar thalamus in the rat

1990 • 28 citations

Painful sensory symptoms in neuroleptic-induced extrapyramidal syndromes

1992 • 28 citations

Differential synaptic modulation of polysensory neurons of the intralaminar thalamus by medial and lateral caudate nucleus and substantia nigra

1978 • 27 citations

Neurophysiological aspects of the differential roles of the putamen and caudate nucleus in voluntary movement.

1993 • 27 citations

Inhibitory effects of the κ opiate U50,488 in the substantia nigra pars reticulata

1990 • 27 citations

The Basal Ganglia and Pain

1988 • 27 citations

Analgesia induced by morphine injected into the pallidum

1992 • 26 citations

Neurotransmitters and their receptors in the basal ganglia.

1993 • 26 citations

Post-traumatic Basal Ganglia Hemorrhage

1991 • 26 citations

Laminar organization of the substantia nigra pars reticulata in the macaque monkey, with special reference to the caudato-nigro-tectal link

1993 • 25 citations

The interrelations between cell groups in the caudal diencephalon of the rat projecting to the striatum and to the medulla oblongata

1984 • 25 citations

Chapter 39 Somatosensory input to dopamine neurones of the monkey midbrain: responses to pain pinch under anaesthesia and to active touch in behavioural context

1989 • 25 citations

Circadian fluctuations in pain responsiveness and brain Met-enkephalin-like immunoreactivity in the rat

1988 • 25 citations

Successful treatment of thalamic pain with apomorphine

1978 • 24 citations

Electrophysiological evidence for a non-opioid interaction between dynorphin and GABA in the substantia nigra of the rat

1987 • 24 citations

Direct projections from the caudal spinal trigeminal nucleus to the striatum in the cat

1987 • 24 citations

Responses of units in the mesolimbic system to olfactory and somatosensory stimuli: modulation of sensory input by ventral tegmental stimulation

1990 • 23 citations

Further studies of the effects of intranigral morphine on behavioral responses to noxious stimuli

1990 • 23 citations

Chapter 5 Neuropeptides and parkinson's disease

1986 • 23 citations

Effects of bilateral injection of GABA into the substantia nigra on spontaneous behavior and measures of analgesia

1988 • 22 citations

Madopar HBS in Parkinson patients with nocturnal akinesia

1988 • 22 citations

The spino(trigemino)-ponto-amygdaloid pathway: Electrophysiological evidence for an involvement in pain processes

1990 • 22 citations

Cerebral Hyperemia During Spontaneous Cluster Headaches With Excessive Cerebral Vasoconstriction to Hyperoxia

1991 • 22 citations

Ultrastructural morphology of projections from the medial geniculate nucleus and its adjacent region to the basal ganglia

1992 • 22 citations

Hippocampal and neostriatal inhibition of extralemniscal thalamic unitary responses in the cat

1971 • 21 citations

The effects of stimulation of trigeminal sensory afferents upon caudate units in cats

1979 • 20 citations

Morphine-induced alterations of local cerebral glucose utilization in the basal ganglia of rats

1989 • 20 citations

Oral sensorimotor defects in patients with Parkinson's disease.

1987 • 20 citations

The projection pattern of the suprageniculate nucleus to the caudate nucleus in cats

1986 • 20 citations

Opposing effect of apomorphine on antinociceptive activityfx of morphine: a dose-dependent phenomenon

1989 • 20 citations

Development of somatosensory responsiveness in the basal ganglia in awake cats

1985 • 20 citations

Effects of kainic acid injections in the striatum on physiologic and behavioral functions in conscious rats

1984 • 19 citations

Dissociated effects of apomorphine on various nociceptive responses in mice

1986 • 19 citations

Suppression of nociceptive responses in parafascicular neurons by stimulation of substantia nigra: an analysis of related inhibitory pathways

1992 • 19 citations

Aging reduces somatosensory responsiveness of caudate neurons in the awake cat

1987 • 19 citations

Chapter 2 Distribution of peptides in basal ganglia

1986 • 19 citations

Somatosensory phenomena in Huntington's disease

1988 • 19 citations

Afferent pathways to points of self-stimulation in the medial prefrontal cortex of the rat as revealed by the horseradish peroxidase technique

1983 • 19 citations

Thalamic connections of the ground squirrel superior colliculus and their topographic relations.

1988 • 18 citations

Prolonged changes in dopaminergic terminal excitability and short changes in dopaminergic neuron discharge rate after short peripheral stimulation in monkey

1985 • 18 citations

The effects of bilateral intranigral microinjection of selective opioid agonists on behavioral responses to noxious thermal stimuli

1991 • 17 citations

Evaluation of the role of antinociception in self-injurious behavior following intranigral injection of muscimol

1986 • 17 citations

Pallidal substrate of morphine-induced locomotion

1992 • 17 citations

Regional differences within the caudate nucleus for suppression of extralemniscal thalamic units

1973 • 17 citations

Thalamocaudate projections in the macaque monkey (a horseradish peroxidase study).

1991 • 16 citations

Pain threshold and polysynaptic components of the blink reflex in Parkinson's disease.

1989 • 16 citations

The deafferentation syndrome in the rat: Effects of intraventricular apomorphine

1988 • 16 citations

Dibutyryl cAMP stimulates analgesia in rats bearing a ventricular adrenal medulla transplant

1990 • 15 citations

Clinical Characteristics of Headache in Parkinson's Disease

1983 • 15 citations

The association cortex and the basal ganglia: a neuroanatomical view upon their relationship based on hodological studies.

1991 • 15 citations

The antinociceptive effect of intranigral injection of morphine in ketamine- and halothane-anesthetized rats

1990 • 14 citations

Chapter 3 Physiology of peptides in basal ganglia

1986 • 14 citations

Electrical stimulation of the substantia nigra does not increase tail-flick latency in the rat

1985 • 14 citations

Electrophysiological investigation of the connection between the substantia nigra and the amygdala in rat

1980 • 13 citations

Spinal Dopamine Mechanisms and Primary Sensory Symptoms in Parkinson's Disease

1987 • 12 citations

Early Parkinsonism

1986 • 12 citations

Both thermal and nociceptive afferents influence the unit activity of the neurons in the corpus striatum

1985 • 12 citations

Intracellular responses in the centrum medianum-parafascicular complex of the cat following medial and lateral caudate, substantia nigra and peripheral stimulation

1981 • 11 citations

Levodopa and induced-pain response. A study of patients with Parkinsonian and pain syndromes

1973 • 11 citations

Depression and Parkinson's disease

2002 • 11 citations

Hereditary Motor and Sensory Neuropathy With Treatable Extrapyramidal Features

1992 • 11 citations

The effects of movements on caudate sensory responses

1989 • 11 citations

Rat brain sites responsive to etorphine: Analgesia and catatonia.

1983 • 11 citations

An intracellular analysis of the entopeduncular inputs on the centrum medianum-parafascicular nuclear complex in cats

1985 • 11 citations

Anticholinergic-induced analgesia: possible role for the cholinergic system in abnormal sensory symptoms in Parkinson's disease

1986 • 11 citations

Parkinson's Disease, Depression, and Chronic Pain

1991 • 10 citations

Rat brain sites responsive to etorphine: Analgesia and catatonia.

1983 • 9 citations

Caudate and hippocampal inhibition of extralemniscal thalamic unitary responses and their blockade by strychnine in cats

1976 • 9 citations

A TREATISE ON DISEASES OF THE NERVOUS SYSTEM

1905 • 9 citations

Hypothalamic Compensatory Mechanisms in Parkinson's Disease

1989 • 8 citations

Striatal neuronal responses to scrotal temperature changes and dopaminergic drugs

1985 • 8 citations

Chapter 58 Possible mechanisms of action of adrenal transplants in Parkinson's disease

1990 • 8 citations

Pineal melatonin and sensory symptoms in Parkinson disease

1989 • 7 citations

Early Morning Headache of Parkinson's Disease: A Hitherto Unrecognized Symptom?

1987 • 7 citations

Influences of electrical lesions of the dopaminergic system on morphine- and U-50,488H-induced analgesia in rats

1987 • 6 citations

Ultrastructural characteristics of substance P-immunoreactive terminals in marginal division of rat striatum.

1991 • 6 citations

Pentobarbital attenuates the antinociceptive effect of intranigral morphine

1989 • 6 citations

Direct striatothalamic projections in the neonatal rat

1990 • 6 citations

Correlations between the receptive field properties and morphology of neurons in the deep layers of the hamster's superior colliculus

1993 • 5 citations

Neuronal responses to bradykinin

1978 • 5 citations

Chapter 71 Autologous adrenal medulla to caudate nucleus transplantation in advanced Parkinson's disease: 18 month results

1990 • 4 citations

Effect of bilateral caudatal lesion on pain threshold in rats.

1984 • 4 citations

A TREATISE ON DISEASES OF THE NERVOUS SYSTEM

1906 • 3 citations

Pure sensory stroke confirmed by CT scan.

1991 • 3 citations

Spontaneous and evoked activity of the caudate neurons to central and peripheral stimuli after brain lesions

1992 • 2 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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The role of the basal ganglia in nociception and pain (1995) – Pain | Metascience Observatory Explorer