Reward‐aversion circuitry in analgesia and pain: Implications for psychiatric disorders

Predictive Reward Signal of Dopamine Neurons

1998 • 4,446 citations

Neuronal Plasticity: Increasing the Gain in Pain

2000 • 3,672 citations

Dopamine, learning and motivation

2004 • 3,146 citations

The Role of the Medial Frontal Cortex in Cognitive Control

2004 • 2,883 citations

Molecular mechanisms of nociception

2001 • 2,564 citations

Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens

2001 • 2,192 citations

Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain

2004 • 1,961 citations

The Neuropsychology of Anxiety

2003 • 1,928 citations

The emotional brain, fear, and the amygdala.

2003 • 1,669 citations

Pain-related fear is more disabling than pain itself: evidence on the role of pain-related fear in chronic back pain disability

1999 • 1,628 citations

Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network

2002 • 1,466 citations

Physiological Role of Pleasure

1971 • 1,462 citations

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

1969 • 1,355 citations

Chronic Back Pain Is Associated with Decreased Prefrontal and Thalamic Gray Matter Density

2004 • 1,330 citations

The Brain and Emotion

1998 • 1,275 citations

Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications

1995 • 1,267 citations

Acute Effects of Cocaine on Human Brain Activity and Emotion

1997 • 1,263 citations

Advances in Neuropathic Pain

2003 • 1,238 citations

Endogenous pain control mechanisms: Review and hypothesis

1978 • 1,217 citations

The amygdala and reward

2002 • 1,156 citations

Effects of Desipramine, Amitriptyline, and Fluoxetine on Pain in Diabetic Neuropathy

1992 • 1,097 citations

Dopamine and the regulation of cognition and attention

2002 • 1,069 citations

Dissociation Of Working Memory from Decision Making within the Human Prefrontal Cortex

1998 • 1,057 citations

Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation

2003 • 895 citations

Brain Reward Circuitry

2002 • 875 citations

Fear and anxiety: divergent effects on human pain thresholds

2000 • 871 citations

Psychological aspects of persistent pain: current state of the science

2004 • 865 citations

Imaging how attention modulates pain in humans using functional MRI

2002 • 858 citations

State-dependent opioid control of pain

2004 • 852 citations

Pain catastrophizing and neural responses to pain among persons with fibromyalgia

2004 • 852 citations

Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study

1994 • 840 citations

Plasticity of the Hippocampus: Adaptation to Chronic Stress and Allostatic Load

2001 • 836 citations

Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety

2003 • 836 citations

Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain

2001 • 832 citations

The collected works of Spinoza

1985 • 816 citations

Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network

2001 • 803 citations

Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors

2005 • 754 citations

THE SKIN SENSES

1969 • 744 citations

Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial

2004 • 732 citations

Synaptic Mechanisms Underlie Nicotine-Induced Excitability of Brain Reward Areas

2002 • 685 citations

Neural circuitry underlying voluntary suppression of sadness

2003 • 681 citations

The Amygdala and Persistent Pain

2004 • 679 citations

Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression

2000 • 651 citations

The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

2001 • 637 citations

Pain processing during three levels of noxious stimulation produces differential patterns of central activity

1997 • 632 citations

A double‐blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder

2004 • 623 citations

Reward deficiency syndrome: genetic aspects of behavioral disorders

2000 • 620 citations

Comorbidity of migraine and depression

2003 • 608 citations

Neurobiological mechanisms in the transition from drug use to drug dependence

2003 • 575 citations

Painful stimuli evoke different stimulus–response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single‐trial fMRI study

2002 • 575 citations

The organization of afferent projections to the midbrain periaqueductal gray of the rat

1982 • 538 citations

Anterior Cingulate: Single Neuronal Signals Related to Degree of Reward Expectancy

2002 • 510 citations

Chronic pain patients are impaired on an emotional decision-making task

2004 • 504 citations

Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology

2004 • 504 citations

Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli

1994 • 500 citations

Reward Circuitry Activation by Noxious Thermal Stimuli

2001 • 490 citations

Appetitive and Aversive Olfactory Learning in Humans Studied Using Event-Related Functional Magnetic Resonance Imaging

2002 • 479 citations

Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy

2002 • 461 citations

Chronic Pain, Chronic Stress and Depression: Coincidence or Consequence?

2001 • 460 citations

Destruction of dopaminergic nerve terminals in nucleus accumbens: Effect on d-amphetamine self-administration

1979 • 460 citations

Stress and plasticity in the limbic system.

2003 • 459 citations

Risky Business: Emotion, Decision-Making, and Addiction

2003 • 454 citations

The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions

2004 • 452 citations

Direct Activation of the Ventral Striatum in Anticipation of Aversive Stimuli

2003 • 445 citations

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

1997 • 435 citations

Opponent appetitive-aversive neural processes underlie predictive learning of pain relief

2005 • 433 citations

Pain modulation: expectation, opioid analgesia and virtual pain

2000 • 420 citations

Short-term infusion of the μ-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal

2003 • 414 citations

A cross-national study of the course of persistent pain in primary care

2001 • 407 citations

An examination of the relationship between chronic pain and post-traumatic stress disorder

2003 • 401 citations

Early life influences on life‐long patterns of behavior and health

2003 • 395 citations

Dissociative anesthesia: further pharmacologic studies and first clinical experience with the phencyclidine derivative CI-581.

1966 • 389 citations

The neuropsychology of anxiety

1983 • 383 citations

Neural circuitry underlying pain modulation: expectation, hypnosis, placebo

2003 • 381 citations

Depression as a risk factor for onset of an episode of troublesome neck and low back pain

2003 • 359 citations

Memory Systems in the Brain

2000 • 350 citations

Glutamatergic activation of anterior cingulate cortex produces an aversive teaching signal

2004 • 342 citations

Neuroimaging abnormalities in the subgenual prefrontal cortex: implications for the pathophysiology of familial mood disorders

1998 • 341 citations

Persistent pain and depression: a biopsychosocial perspective

2003 • 335 citations

Human brain activation under controlled thermal stimulation and habituation to noxious heat: An fMRI study

1999 • 331 citations

Apathy: Why Care?

2005 • 330 citations

Psychologic Distress and Low Back Pain

1995 • 324 citations

Pain intolerance in opioid-maintained former opiate addicts: effect of long-acting maintenance agent

2001 • 315 citations

Pregabalin in Generalized Anxiety Disorder: A Placebo-Controlled Trial

2003 • 313 citations

Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial

1991 • 302 citations

Dissociative Anesthesia

1966 • 293 citations

Opiate reward: Sites and substrates

1989 • 291 citations

Synaptic Regulation of Mesocorticolimbic Dopamine Neurons

1996 • 289 citations

Cerebral Processing of Acute Skin and Muscle Pain in Humans

1997 • 281 citations

An Overview of Neuropathic Pain: Syndromes, Symptoms, Signs, and Several Mechanisms

2002 • 281 citations

Localization of drug reward mechanisms by intracranial injections

1992 • 274 citations

Pain-Induced Analgesia Mediated by Mesolimbic Reward Circuits

1999 • 264 citations

Major Depression and Insomnia in Chronic Pain

2002 • 261 citations

The organization and function of endogenous antinociceptive systems

1996 • 255 citations

Reinforcing effects of morphine in the nucleus accumbens

1982 • 254 citations

The role of the brain reward system in depression

2001 • 247 citations

Learning about pain: The neural substrate of the prediction error for aversive events

2000 • 242 citations

Toward the development of a motivational model of pain self-management

2003 • 238 citations

Central Neural Mechanisms that Interrelate Sensory and Affective Dimensions of Pain

2002 • 233 citations

Nucleus centralis of the amygdala and the globus pallidus ventralis: electrophysiological evidence for an involvement in pain processes

1992 • 229 citations

Behavioral planning in the prefrontal cortex

2001 • 228 citations

Chapter 14 Involvement of the spino-parabrachio -amygdaloid and -hypothalamic pathways in the autonomic and affective emotional aspects of pain

1996 • 226 citations

Striatal dopamine D2 receptors in modulation of pain in humans: a review

2004 • 223 citations

Predicting Complaints of Impaired Cognitive Functioning in Patients with Chronic Pain

2001 • 216 citations

Functional Relationship Among Medial Prefrontal Cortex, Nucleus Accumbens, and Ventral Tegmental Area in Locomotion and Reward

2000 • 215 citations

The Effect of Duloxetine on Painful Physical Symptoms in Depressed Patients

2004 • 210 citations

Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: Elements of face and predictive validity

1995 • 205 citations

Structural and functional brain changes in posttraumatic stress disorder.

2004 • 202 citations

Altered dopamine D2 receptor binding in atypical facial pain

2003 • 199 citations

Relationship Between Clinical Pain Complaints and Pain Sensitivity in Patients With Depression and Panic Disorder

1999 • 184 citations

Neural basis of utility estimation

1997 • 180 citations

A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy

1999 • 172 citations

Regional Brain Activity Changes Associated with Fentanyl Analgesia Elucidated by Positron Emission Tomography

1997 • 159 citations

Addiction Becomes a Brain Disease

2000 • 157 citations

An assessment of the antinociceptive and aversive effects of stimulating identified sites in the rat brain

1985 • 157 citations

Methamphetamine Activates Reward Circuitry in Drug Naïve Human Subjects

2004 • 155 citations

Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats

2003 • 155 citations

Stereotactic Anterior Cingulate Lesions for Persistent Pain: A Report on 68 Cases

1974 • 151 citations

Cognitive impairment in patients with chronic pain: The significance of stress

2003 • 149 citations

Activation of reward circuitry in human opiate addicts

1999 • 149 citations

Patterns of increased brain activity indicative of pain in a rat model of peripheral mononeuropathy

1993 • 146 citations

Augmentation of nociceptive reflexes and chronic deafferentation pain by chemical lesions of either dopaminergic terminals or midbrain dopaminergic neurons

1997 • 143 citations

Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity

2002 • 143 citations

Representations of motivational drives in mesial cortex, medial thalamus, hypothalamus and midbrain

2003 • 141 citations

Human Brain Activity Response to Fentanyl Imaged by Positron Emission Tomography

1996 • 141 citations

Prefrontal cortical hyperactivity in patients with sympathetically mediated chronic pain

2001 • 140 citations

The relationship of pain and depression to cognitive function in rheumatoid arthritis patients

2002 • 140 citations

Suppression of the morphine‐induced rewarding effect in the rat with neuropathic pain: implication of the reduction in µ‐opioid receptor functions in the ventral tegmental area

2002 • 139 citations

Withdrawal hyperalgesia after acute opioid physical dependence in nonaddicted humans: a preliminary study

2003 • 138 citations

A Lateralized Deficit in Morphine Antinociception after Unilateral Inactivation of the Central Amygdala

1998 • 137 citations

Cerebral Responses to Noxious Thermal Stimulation in Chronic Low Back Pain Patients and Normal Controls

2002 • 136 citations

The ascending input to the midbrain periaqueductal gray of the primate

1982 • 135 citations

Analgesia elicited by prefrontal stimulation

1985 • 134 citations

Depression in chronic pain patients: Relation to pain, activity, and sex differences

1985 • 133 citations

Chronic deafferentation in monkeys differentially affects nociceptive and nonnociceptive pathways distinguished by specific calcium-binding proteins and down-regulates gamma-aminobutyric acid type A receptors at thalamic levels.

1992 • 132 citations

Brain-Derived Neurotrophic Factor Is Essential for Opiate-Induced Plasticity of Noradrenergic Neurons

2002 • 129 citations

Dose-dependent Regional Cerebral Blood Flow Changes during Remifentanil Infusion in Humans

2001 • 126 citations

Genetics and Epigenetics in Major Psychiatric Disorders

2005 • 124 citations

Effects of limbic lesions on passive avoidance and reactivity to shock.

1968 • 123 citations

Bilateral Anterior Cingulotomy for Chronic Noncancer Pain

1999 • 118 citations

THE “OUCHLESS EMERGENCY DEPARTMENT*”

1999 • 116 citations

Pain-related anxiety predicts non-specific physical complaints in persons with chronic pain

1998 • 115 citations

Regional Brain Activity Changes Associated with Fentanyl Analgesia Elucidated by Positron Emission Tomography

1997 • 115 citations

Analgesia to painful stimuli in affective illness

1979 • 113 citations

Hypothalamo-pituitary-adrenal axis dysfunction as a contributory factor to chronic pain and depression

2004 • 113 citations

FMRI Measurement of CNS Responses to Naloxone Infusion and Subsequent Mild Noxious Thermal Stimuli in Healthy Volunteers

2004 • 112 citations

Analgesia produced by lidocaine microinjection into the dentate gyms

1992 • 110 citations

NEUROBIOLOGICAL CONSTRAINTS ON BEHAVIORAL MODELS OF MOTIVATION

1997 • 108 citations

Increased anterior corpus callosum size associated positively with hypnotizability and the ability to control pain

2004 • 104 citations

The functional organization of the brain in chronic pain

2000 • 103 citations

Depressive Symptoms as a Risk Factor for Disabling Back Pain in Community‐Dwelling Older Persons

2003 • 97 citations

Altered Nucleus Accumbens Circuitry Mediates Pain-Induced Antinociception in Morphine-Tolerant Rats

2002 • 93 citations

Emotional and personality changes following cingulotomy.

2001 • 91 citations

Painful neuropathies

2003 • 87 citations

Reorganization of sensory modalities evoked by microstimulation in region of the thalamic principal sensory nucleus in patients with pain due to nervous system injury

1998 • 87 citations

Drug addiction: Functional neurotoxicity of the brain reward systems

2001 • 86 citations

Analgesia and the neural substrate of reward

1989 • 84 citations

Pain in Parkinsonʼs disease

1985 • 82 citations

Neuroplastic Changes Related to Pain Occur at Multiple Levels of the Human Somatosensory System: A Somatosensory-Evoked Potentials Study in Patients with Cervical Radicular Pain

2000 • 80 citations

Long-term changes in behavior and regional cerebral blood flow associated with painful peripheral mononeuropathy in the rat

2002 • 80 citations

Alcoholism and the dopaminergic system: a review

1996 • 79 citations

Potentiation of Opioid Analgesia in Dopamine₂Receptor Knock-Out Mice: Evidence for a Tonically Active Anti-Opioid System

2001 • 73 citations

Fear of pain in orofacial pain patients

2001 • 72 citations

Behavioural dissociation of the enkephalinergic systems of nucleus accumbens and nucleus caudatus

1977 • 71 citations

Pain Flashbacks in Posttraumatic Stress Disorder

2004 • 67 citations

Central post-stroke pain: a challenge for the scientist and the clinician

1995 • 67 citations

The role of psychiatric disorders in fibromyalgia

2001 • 64 citations

Neurocognitive performance and emotional status in chronic pain patients.

1999 • 62 citations

Pain responsivity in major depression and bipolar disorder

1995 • 61 citations

Place aversion induced by blockade of μ or activation of κ opioid receptors in the dorsal periaqueductal gray matter

2000 • 60 citations

Heroin Addiction: Neurobiology, Pharmacology, and Policy

1991 • 59 citations

Insights into the pathophysiology of neuropathic pain through functional brain imaging

2003 • 59 citations

Opioid receptors: past, present and future

1995 • 58 citations

Pain in Parkinson’s disease

2004 • 58 citations

The neurobiology of addiction

2003 • 52 citations

Cerebral responses to pain in patients suffering acute post‐dental extraction pain measured by positron emission tomography (PET)

1999 • 51 citations

Attenuation of neuropathic manifestations by local block of the activities of the ventrolateral orbito-frontal area in the rat

2003 • 46 citations

Antidepressant mechanisms: functional and molecular correlates of excitatory amino acid neurotransmission

2002 • 45 citations

L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses.

1992 • 40 citations

A Study of the Connections of Nociceptive Substantia Nigra Neurones

1982 • 37 citations

Chapter 8 Studies of PAG/PVG stimulation for pain relief in humans

1988 • 35 citations

Cognitive deficits from bilateral cingulotomy for intractable pain in man.

1971 • 34 citations

Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens

2005 • 33 citations

Opioid receptors: past, present and future

1995 • 32 citations

Funktionsst�rung der hypothalamisch-hyphophys�r-adrenalen Achse bei Patienten mit akuten, chronischen und intervallartigen Schmerzsyndromen

2004 • 31 citations

Endogenous opioids mediate basal hedonic tone independent of dopamine d-1 or d-2 receptor activation

2004 • 30 citations

Human Brain Activity Response to Fentanyl Imaged by Positron Emission Tomography

1996 • 26 citations

The role of the central nucleus of the amygdala in nociception and aversion

2003 • 26 citations

Stimulation-produced analgesia (SPA) from brain-stem and diencephalic sites in the rat: Relationships between analgesia, aversion, seizures and catalepsy

1988 • 24 citations

Low dose of morphine microinjected in the ventral periaqueductal gray matter of the rat depresses responses of nociceptive ventrobasal thalamic neurons

1983 • 19 citations

CNS Activation by Noxious Heat to the Hand or Foot: Site-Dependent Delay in Sensory But Not Emotion Circuitry

2004 • 19 citations

Increased perception of post-ischemic paresthesias in depressed subjects

2003 • 18 citations

The role of the central nucleus of the amygdala in nociception and aversion

2003 • 18 citations

Differences in cognitions during chest pain of patients with panic disorder and ischemic heart disease

1996 • 16 citations

Le concept d‘apathie : intérêt et limites

2004 • 11 citations

Facilitating action of medial prefrontal cortex upon the noxious thermally-evoked responses in thalamic centralis lateralis nucleus.

1991 • 6 citations