Mechanism of Synergy of N-(4-Hydroxyphenyl)Retinamide and ABT-737 in Acute Lymphoblastic Leukemia Cell Lines: Mcl-1 Inactivation

Mitochondria and Apoptosis

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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The stress-activated protein kinase subfamily of c-Jun kinases

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

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Redox Regulation of Cellular Signalling

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

2000 • 994 citations

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

2006 • 993 citations

Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A

1999 • 635 citations

14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

2000 • 634 citations

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737

2007 • 581 citations

Short tandem repeat profiling provides an international reference standard for human cell lines

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Apoptosis-based therapies for hematologic malignancies

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Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation

2007 • 379 citations

Influence of Bcl-2 Family Members on the Cellular Response of Small-Cell Lung Cancer Cell Lines to ABT-737

2007 • 302 citations

BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity

1997 • 302 citations

Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by N-(4-Hydroxyphenyl)- retinamide in Neuroblastoma Cell Lines

1999 • 289 citations

Survival Factor-Mediated BAD Phosphorylation Raises the Mitochondrial Threshold for Apoptosis

2002 • 270 citations

The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs)

2001 • 267 citations

p90RSK Blocks Bad-mediated Cell Death via a Protein Kinase C-dependent Pathway

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A novel Bcl-2/Bcl-XL/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma

2006 • 229 citations

Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism

2000 • 219 citations

Phosphorylation and Inactivation of Myeloid Cell Leukemia 1 by JNK in Response to Oxidative Stress

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Heterodimerization-independent Functions of Cell Death Regulatory Proteins Bax and Bcl-2 in Yeast and Mammalian Cells

1997 • 171 citations

Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo

2007 • 153 citations

A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic DrugsIn vitroandIn vivo

2006 • 145 citations

Phase I Trial of Oral Fenretinide in Children With High-Risk Solid Tumors: A Report From the Children's Oncology Group (CCG 09709)

2006 • 144 citations

High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate

1997 • 138 citations

Role of antioxidants and intracellular free radicals in retinamide- induced cell death

1997 • 133 citations

RETINOID THERAPY OF CHILDHOOD CANCER

2001 • 128 citations

Targeting BCL‐2 family proteins to overcome drug resistance in non‐small cell lung cancer

2007 • 111 citations

N-(4-Hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells

2005 • 101 citations

A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

2007 • 96 citations

Concomitant Inhibition of MDM2 and Bcl-2 Protein Function Synergistically Induce Mitochondrial Apoptosis in AML

2006 • 95 citations

Phase II Study of Fenretinide (NSC 374551) in Adults With Recurrent Malignant Gliomas: A North American Brain Tumor Consortium Study

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Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation

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N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes

2002 • 83 citations

Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin.

2003 • 81 citations

GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.

2002 • 80 citations

Bcl-2 family members in childhood acute lymphoblastic leukemia: relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome

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Fenretinide induces sustained‐activation of JNK/p38 MAPK and apoptosis in a reactive oxygen species‐dependent manner in neuroblastoma cells

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Synergistic induction of apoptosis of neuroblastoma by fenretinide or CD437 in combination with chemotherapeutic drugs

2000 • 65 citations

DIMSCAN: A Microcomputer Fluorescence-Based Cytotoxicity Assay for Preclinical Testing of Combination Chemotherapy

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Improved Oral Delivery of N-(4-Hydroxyphenyl)Retinamide with a Novel LYM-X-SORB Organized Lipid Complex

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Phase II trial of fenretinide in advanced renal carcinoma

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Effects of retinoic acid and fenretinide on the c-erbB-2 expression, growth and cisplatin sensitivity of breast cancer cells

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Phosphoinositide 3‐kinase/Akt inhibition increases arsenic trioxide‐induced apoptosis of acute promyelocytic and T‐cell leukaemias

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Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis

2006 • 40 citations

Activity of fenretinide plus chemotherapeutic agents in small-cell lung cancer cell lines

1999 • 39 citations

N-(4-hydroxyphenyl) retinamide (4HPR) enhances TRAIL-mediated apoptosis through enhancement of a mitochondrial-dependent amplification loop in ovarian cancer cell lines

2004 • 38 citations

Tirapazamine Cytotoxicity for Neuroblastoma Is p53 Dependent

2005 • 37 citations

Prognostic role of bcl-xL and p53 in childhood acute lymphoblastic leukemia

2005 • 35 citations

Assessment of Bcl-2 Expression as Modulator of Fas Mediated Apoptosis in Acute Leukemia

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Chemoprevention of Breast Cancer with Fenretinide

2001 • 28 citations

In Vitro Testing of Chemosensitivity in Physiological Hypoxia

2005 • 23 citations

Ocular effects of fenretinide, a vitamin A analog, in a chemoprevention trial of bladder cancer.

2000 • 20 citations

Phase I Trial of Fenretinide (4-HPR) Intravenous Emulsion for Hematologic Malignancies.

2007 • 4 citations