Heterodimerization-independent Functions of Cell Death Regulatory Proteins Bax and Bcl-2 in Yeast and Mammalian Cells

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

1995 • 491 citations

Bax-independent inhibition of apoptosis by Bcl-XL

1996 • 484 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

Structure-Function Analysis of Bcl-2 Protein

1995 • 419 citations

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL

1997 • 381 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Structure-Function Comparisons of the Proapoptotic Protein Bax in Yeast and Mammalian Cells

1996 • 280 citations

A Common Binding Site Mediates Heterodimerization and Homodimerization of Bcl-2 Family Members

1997 • 128 citations

Human Bak Induces Cell Death in Schizosaccharomyces pombe with Morphological Changes Similar to Those with Apoptosis in Mammalian Cells

1997 • 125 citations

Modulation of Cell Death in Yeast by the Bcl-2 Family of Proteins

1997 • 105 citations

Bax Can Antagonize Bcl-XL during Etoposide and Cisplatin-induced Cell Death Independently of Its Heterodimerization with Bcl-XL

1996 • 101 citations

Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. I. Transmembrane segment M2 of the nicotinic cholinergic receptor channel is a key pore-lining structure

1993 • 75 citations

Biochemical and functional comparisons of Mcl-1 and Bcl-2 proteins: evidence for a novel mechanism of regulating Bcl-2 family protein function.

1995 • 65 citations

Bax Homodimerization Is Not Required for Bax to Accelerate Chemotherapy-induced Cell Death

1996 • 49 citations