Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis, and a survey of existing data

1984 • 610 citations

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

1979 • 523 citations

SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells

1986 • 391 citations

The Phenomenon of Reoxygenation and Its Implications for Fractionated Radiotherapy

1972 • 296 citations

Acute hypoxia in tumors: Implications for modifiers of radiation effects

1986 • 267 citations

Potential bioreductive alkylating agents. 1. Benzoquinone derivatives

1972 • 200 citations

Carcinoma of the cervix—anaemia, radiotherapy and hyperbaric oxygen

1983 • 169 citations

Intracapillary oxyhemoglobin saturation of malignant tumors in humans

1981 • 131 citations

Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233

1988 • 94 citations

Hypoxic cells as specific drug targets for chemotherapy.

1987 • 87 citations

Potential Bioreductive Alkylating Agents

1976 • 78 citations

Variation in response of xenografts of colo-rectal carcinoma to chemotherapy

1978 • 74 citations

Preferential Radiosensitization of Mouse Sarcoma Relative to Normal Skin by Chronic Intra-Arterial Infusion of Halogenated Pyrimidine Analogs<xref ref-type="fn" rid="FN2">2</xref>

1971 • 63 citations

Sensitizers and radiation dose fractionation: Results and interpretations

1986 • 59 citations

Radiosensitization of hypoxic cells in vivo by SR 2508 at low radiation doses: A preliminary report

1984 • 51 citations

Pre- and post-irradiation adiosensitization by SR 4233

1989 • 48 citations

SR 4233: A tumor specific radiosensitizer active in fractionated radiation regimes

1991 • 45 citations

Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.

1983 • 35 citations

Aerobic radiosensitization by sr 4233 in vitro and in vivo

1990 • 26 citations

Aerobic Radiosensitization by SR 4233 in Rodent and Human Cells: Mechanistic and Therapeutic Implications

1991 • 14 citations