A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic DrugsIn vitroandIn vivo

The Hallmarks of Cancer

2000 • 27,569 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

2005 • 3,292 citations

Apoptosis

2002 • 2,190 citations

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

2005 • 1,751 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

The Bcl-2 family: roles in cell survival and oncogenesis

2003 • 1,448 citations

Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

2004 • 1,285 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

2000 • 1,170 citations

Structure of Bax

2000 • 1,066 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

1997 • 872 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Structural biology of the Bcl-2 family of proteins

2003 • 706 citations

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

1999 • 473 citations

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

2001 • 445 citations

Solution structure of the antiapoptotic protein bcl-2

2001 • 433 citations

Expression of bcl-xL can confer a multidrug resistance phenotype

1995 • 421 citations

An informatics approach identifying markers of chemosensitivity in human cancer cell lines.

2000 • 394 citations

Solution Structure of the Proapoptotic Molecule BID

1999 • 387 citations

Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening

2001 • 312 citations

Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy

2005 • 286 citations

Oblimersen Bcl-2 Antisense: Facilitating Apoptosis in Anticancer Treatment

2002 • 278 citations

Bcl-2 and Bcl-XL Can Differentially Block Chemotherapy-Induced Cell Death

1997 • 243 citations

Mitotic Phosphorylation of Bcl-2 during Normal Cell Cycle Progression and Taxol-induced Growth Arrest

1998 • 231 citations

Thiazolidenediones Mediate Apoptosis in Prostate Cancer Cells in Part through Inhibition of Bcl-xL/Bcl-2 Functions Independently of PPARγ

2005 • 221 citations

Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases.

1997 • 207 citations

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

2003 • 170 citations

Small cell carcinomas of the lung express the Bcl-2 protein.

1994 • 163 citations

Bcl-xL is phosphorylated in malignant cells following microtubule disruption.

1998 • 160 citations

Frequency of bcl-2 expression in non-Hodgkin's lymphoma: a study of 778 cases with comparison of marginal zone lymphoma and monocytoid B-cell hyperplasia.

1998 • 158 citations

Combination of taxanes with radiation: preclinical studies.

1999 • 135 citations

Prognostic value of bcl-2 oncoprotein expression in stage II colon carcinoma.

1995 • 127 citations

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

2006 • 126 citations

Solution Structure of Human BCL-w

2003 • 123 citations

"Loop" domain is necessary for taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting taxol-induced cytosolic accumulation of cytochrome c and apoptosis.

1998 • 116 citations

Microtubule-Targeting Drugs Induce Bcl-2 Phosphorylation and Association with Pin1

2001 • 94 citations

Bcl-2 Mediates Chemoresistance in Matched Pairs of Primary Eμ-myc Lymphomas in Vivo

2001 • 91 citations

Targeting Apoptosis via Chemical Design

2004 • 90 citations

Bcl-2 family proteins: regulators of chemoresistance in cancer

1995 • 89 citations

Development of a high-throughput fluorescence polarization assay for Bcl-xL

2002 • 88 citations

A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth

2004 • 76 citations

Overexpression of Bcl-xL in Human Breast Cancer Cells Enhances Organ-Selective Lymph Node Metastasis

2004 • 57 citations

In vivo suppression of Bcl‐X_L expression facilitates chemotherapy‐induced leukaemia cell death in a SCID/NOD‐Hu model

2001 • 43 citations

Estrogen withdrawal‐induced human breast cancer tumour regression in nude mice is prevented by Bcl‐2

1998 • 25 citations

The mitosis-specific monoclonal antibody MPM-2 recognizes phosphoproteins associated with the nuclear envelope in Chlamydomonas reinhardtii cells.

1990 • 15 citations