In Vitro Testing of Chemosensitivity in Physiological Hypoxia

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

Hypoxia and drug resistance

1994 • 555 citations

Treatment Resistance of Solid Tumors

2001 • 533 citations

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies

2003 • 529 citations

Tumor hypoxia: its impact on cancer therapy

1987 • 410 citations

Biological consequences of tumor hypoxia

2001 • 343 citations

Tumor hypoxia: A target for selective cancer therapy

2003 • 341 citations

Oxygen in Human Tumors: Correlations between Methods of Measurement and Response to Therapy: Summary of a Workshop Held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland

1993 • 298 citations

Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by N-(4-Hydroxyphenyl)- retinamide in Neuroblastoma Cell Lines

1999 • 289 citations

Tumor Microenvironment and the Response to Anticancer Therapy

2002 • 230 citations

Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.

2001 • 230 citations

Measurement of Human Tumour Oxygenation Status by a Polarographic Needle Electrode: An analysis of inter- and intratumour heterogeneity

1994 • 180 citations

Depletion of Glutathione by Buthionine Sulfoximine Is Cytotoxic for Human Neuroblastoma Cell Lines via Apoptosis

1999 • 105 citations

Physiologic Mechanisms of Therapeutic Resistance: Blood Flow and Hypoxia

1995 • 91 citations

Therapeutic Advantage of Hypoxic Cells in Tumors: A Theoretical Study

1991 • 91 citations

Hypoxic cells as specific drug targets for chemotherapy.

1987 • 87 citations

Hypoxia‐induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro

1994 • 85 citations

Approaches to defining the mechanism of enhancement by Fluosol-DA 20% with carbogen of melphalan antitumor activity.

1987 • 77 citations

Heterogeneity of polarographic oxygen tension measurements in cervix cancer: An evaluation of within and between tumor variability, probe position, and track depth

1997 • 75 citations

Homeostasis of Oxygen Supply in Liver and Kidney

1973 • 69 citations

How to overcome (and exploit) tumor hypoxia for targeted gene therapy

2003 • 69 citations

Bioreductive drugs and the selective induction of tumour hypoxia

1990 • 55 citations

Synergistic cytotoxicity of buthionine sulfoximine (BSO) and intensive melphalan (L-PAM) for neuroblastoma cell lines established at relapse after myeloablative therapy

2002 • 54 citations

Bone Marrow Gas Tensions, Bone Marrow Blood Flow, and Erythropoiesis in Man

1963 • 51 citations

The effect of hypoxia on acquired drug resistance and response to epidermal growth factor in chinese hamster lung fibroblasts and human breast‐cancer cells in vitro

1993 • 43 citations

A fluorescence digital image microscopy system for quantifying relative cell numbers in tissue culture plates

1996 • 40 citations

Tumor Microenvironment and Hemorheological Abnormalities

2003 • 31 citations

Antagonism of buthionine sulfoximine cytotoxicity for human neuroblastoma cell lines by hypoxia is reversed by the bioreductive agent tirapazamine.

2003 • 27 citations

Intracoronary nitroglycerin, pentaerythritol trinitrate and dipyridamole on intramyocardial oxygen tension

1972 • 25 citations

Mechanisms of resistance to alkylating agents

1994 • 14 citations

Deleted Work

1955 • 0 citations