The Final Maturation of at Least Some Single-Positive Cd4hiThymocytes Does Not Require T Cell Receptor–Major Histocompatibility Complex Contact

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

Developmental Status and Reconstitution Potential of Subpopulations of Murine Thymocytes

1988 • 211 citations

Function and Specificity of T Cell Subsets in the Mouse

1987 • 208 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Studies of thymocytopoiesis in rats and mice. I. Kinetics of appearance of thymocytes using a direct intrathymic adoptive transfer assay for thymocyte precursors.

1986 • 188 citations

The majority of CD4+8- thymocytes are functionally immature.

1991 • 137 citations

The life span of naive alpha/beta T cells in secondary lymphoid organs.

1993 • 130 citations

Production, selection, and maturation of thymocytes with high surface density of TCR.

1994 • 113 citations

MHC class I is required for peripheral accumulation of CD8+ thymic emigrants.

1998 • 112 citations

Recent thymic emigrants are distinct from most medullary thymocytes

1997 • 108 citations

MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants

1998 • 100 citations

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.

1993 • 92 citations

Expansion of mature thymocyte subsets before emigration to the periphery.

1997 • 86 citations

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection.

1995 • 84 citations

Thymic selection and cell division.

1995 • 83 citations

CD69 Expression Discriminates MHC-Dependent and -Independent Stages of Thymocyte Positive Selection

1999 • 83 citations

From stem cells to lymphocytes; biology and transplantation

1997 • 72 citations

Thymocytes expressing CD8 differentiate into CD4+ cells following intrathymic injection.

1988 • 72 citations

The majority of postselection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells.

1995 • 55 citations

Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset.

1989 • 53 citations

Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus

1990 • 51 citations

Intrathymic T-cell development

1995 • 5 citations

Intrathymic T-Cell Development

1994 • 4 citations