INTEGRATIVE BIOLOGY OF PROSTATE CANCER PROGRESSION

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Tissue microarrays for high-throughput molecular profiling of tumor specimens

1998 • 4,104 citations

Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer

2005 • 3,714 citations

ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform

2004 • 3,585 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

The polycomb group protein EZH2 is involved in progression of prostate cancer

2002 • 2,600 citations

Gene expression correlates of clinical prostate cancer behavior

2002 • 2,504 citations

The development of androgen-independent prostate cancer

2001 • 2,285 citations

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

1998 • 2,266 citations

Molecular determinants of resistance to antiandrogen therapy

2003 • 2,212 citations

Prediction of Prognosis for Prostatic Adenocarcinoma by Combined Histological Grading and Clinical Staging

1974 • 2,200 citations

Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome

1998 • 2,163 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

Delineation of prognostic biomarkers in prostate cancer

2001 • 1,694 citations

Applying the principles of stem-cell biology to cancer

2003 • 1,623 citations

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

2003 • 1,587 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

The Hedgehog and Wnt signalling pathways in cancer

2001 • 1,374 citations

Prognostically Useful Gene-Expression Profiles in Acute Myeloid Leukemia

2004 • 1,353 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Gene expression profiling identifies clinically relevant subtypes of prostate cancer

2004 • 1,292 citations

Tissue repair and stem cell renewal in carcinogenesis

2004 • 1,192 citations

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

2003 • 1,147 citations

Systems Biology and New Technologies Enable Predictive and Preventative Medicine

2004 • 1,088 citations

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

2003 • 1,073 citations

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

2004 • 1,057 citations

Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front

2001 • 954 citations

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

2004 • 951 citations

Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems

1999 • 941 citations

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

2004 • 909 citations

Prostate Cancer

2003 • 900 citations

The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway

2004 • 889 citations

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

1997 • 883 citations

Proliferative Inflammatory Atrophy of the Prostate

1999 • 868 citations

Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer.

2001 • 860 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 • 823 citations

Myc-driven murine prostate cancer shares molecular features with human prostate tumors

2003 • 787 citations

Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression

2005 • 778 citations

Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer.

2001 • 755 citations

Gene Expression Alterations in Prostate Cancer Predicting Tumor Aggression and Preceding Development of Malignancy

2004 • 753 citations

Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.

1997 • 719 citations

A resource for large-scale RNA-interference-based screens in mammals

2004 • 685 citations

Pten Dose Dictates Cancer Progression in the Prostate

2003 • 665 citations

Roles for Nkx3.1 in prostate development and cancer

1999 • 660 citations

Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer.

2002 • 656 citations

α-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer

2002 • 633 citations

Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.

1999 • 631 citations

Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease.

2002 • 519 citations

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

2004 • 504 citations

Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

1989 • 497 citations

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

2001 • 495 citations

Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization.

1995 • 490 citations

Human prostate cancer and benign prostatic hyperplasia: molecular dissection by gene expression profiling.

2001 • 489 citations

Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer.

2002 • 478 citations

Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.

1998 • 453 citations

Gene expression profiling predicts clinical outcome of prostate cancer

2004 • 448 citations

CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer

2004 • 406 citations

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

2005 • 402 citations

Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.

2000 • 377 citations

P504S

2001 • 366 citations

A Novel Human Prostate-Specific, Androgen-Regulated Homeobox Gene (NKX3.1) That Maps to 8p21, a Region Frequently Deleted in Prostate Cancer

1997 • 363 citations

Activation of the hedgehog pathway in advanced prostate cancer

2004 • 354 citations

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

2004 • 353 citations

Evaluation of Serum Protein Profiling by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Detection of Prostate Cancer: I. Assessment of Platform Reproducibility

2004 • 349 citations

Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

2001 • 320 citations

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis

2002 • 320 citations

Genetic Alterations in Hormone-Refractory Recurrent Prostate Carcinomas

1998 • 314 citations

Hypermethylation of the Human Glutathione S-Transferase-π Gene (GSTP1) CpG Island Is Present in a Subset of Proliferative Inflammatory Atrophy Lesions but Not in Normal or Hyperplastic Epithelium of the Prostate

2003 • 298 citations

Epigenetic Changes in Prostate Cancer: Implication for Diagnosis and Treatment

2005 • 296 citations

Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.

2003 • 293 citations

Fatty acid synthase: A metabolic oncogene in prostate cancer?

2003 • 293 citations

Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.

1995 • 289 citations

Tumour class prediction and discovery by microarray-based DNA methylation analysis

2002 • 288 citations

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model

2003 • 286 citations

Hepsin promotes prostate cancer progression and metastasis

2004 • 284 citations

Hedgehog Signaling Promotes Prostate Xenograft Tumor Growth

2004 • 280 citations

Multiplex Biomarker Approach for Determining Risk of Prostate-Specific Antigen-Defined Recurrence of Prostate Cancer

2003 • 277 citations

THE BIOLOGY OF HORMONE REFRACTORY PROSTATE CANCER

1999 • 256 citations

Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21.

1996 • 254 citations

GSTP1 CpG Island Hypermethylation Is Responsible for the Absence of GSTP1 Expression in Human Prostate Cancer Cells

2001 • 243 citations

Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis.

2002 • 242 citations

Evaluation of androgen, estrogen (ER alpha and ER beta), and progesterone receptor expression in human prostate cancer by real-time quantitative reverse transcription-polymerase chain reaction assays.

2001 • 242 citations

Gene expression analysis of prostate cancers

2002 • 238 citations

Conditional Loss of Nkx3.1 in Adult Mice Induces Prostatic Intraepithelial Neoplasia

2002 • 235 citations

Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases.

2003 • 229 citations

Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.

2002 • 205 citations

Gene amplifications associated with the development of hormone-resistant prostate cancer.

2003 • 204 citations

Atrophy and hyperplasia in the prostate proper

1954 • 204 citations

GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer

2003 • 198 citations

Androgen receptor gene and hormonal therapy failure of prostate cancer.

1998 • 194 citations

Activated p53 suppresses the histone methyltransferase EZH2 gene

2004 • 193 citations

Poorly Differentiated Breast Carcinoma is Associated with Increased Expression of the Human Polycomb Group EZH2 Gene

2003 • 191 citations

Myc confers androgen-independent prostate cancer cell growth

2003 • 191 citations

An approach to genomewide screens of expressed small interfering RNAs in mammalian cells

2003 • 187 citations

Mutation of the androgen receptor causes oncogenic transformation of the prostate

2005 • 187 citations

Myc confers androgen-independent prostate cancer cell growth

2003 • 186 citations

Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors

2004 • 181 citations

Overexpression, Amplification, and Androgen Regulation of TPD52 in Prostate Cancer

2004 • 162 citations

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

2004 • 159 citations

Peroxisomal branched chain fatty acid ?-oxidation pathway is upregulated in prostate cancer

2004 • 158 citations

Deletion, Methylation, and Expression of the NKX3.1 Suppressor Gene in Primary Human Prostate Cancer

2005 • 158 citations

Alterations of androgen receptor in prostate cancer

2004 • 154 citations

Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1.

2001 • 148 citations

Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers.

1997 • 148 citations

Haploinsufficiency at the Nkx3.1 locus

2003 • 142 citations

Alpha-methylacyl-CoA racemase as an androgen-independent growth modifier in prostate cancer.

2003 • 134 citations

Humoral Immune Response to -Methylacyl-CoA Racemase and Prostate Cancer

2004 • 131 citations

PTEN Up-Regulates the Tumor Metastasis Suppressor Gene Drg-1 in Prostate and Breast Cancer

2004 • 129 citations

Hepsin is Highly Over Expressed in and a New Candidate for a Prognostic Indicator in Prostate Cancer

2004 • 129 citations

Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate cancer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformatics platform dChipSNP.

2003 • 126 citations

Quantitative Proteomic Analysis of Proteins Released by Neoplastic Prostate Epithelium

2004 • 126 citations

A critical role for p27 ^kip1 gene dosage in a mouse model of prostate carcinogenesis

2004 • 122 citations

SERUM PROTEOMIC PROFILING CAN DISCRIMINATE PROSTATE CANCER FROM BENIGN PROSTATES IN MEN WITH TOTAL PROSTATE SPECIFIC ANTIGEN LEVELS BETWEEN 2.5 AND 15.0 NG/ML

2004 • 118 citations

Amplification of EIF3S3 Gene Is Associated with Advanced Stage in Prostate Cancer

2001 • 114 citations

A Novel Repressive E2F6 Complex Containing the Polycomb Group Protein, EPC1, That Interacts with EZH2 in a Proliferation-specific Manner

2004 • 113 citations

Synergy in tumor suppression by direct interaction of Neutral Endopeptidase with PTEN

2004 • 105 citations

PrLZ, a Novel Prostate-Specific and Androgen-Responsive Gene of the TPD52 Family, Amplified in Chromosome 8q21.1 and Overexpressed in Human Prostate Cancer

2004 • 104 citations

PROSTATE CANCER DETECTION ON URINALYSIS FOR α METHYLACYL COENZYME A RACEMASE PROTEIN

2004 • 103 citations

NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter.

2002 • 97 citations

Protein Profiling of Microdissected Prostate Tissue Links Growth Differentiation Factor 15 to Prostate Carcinogenesis

2004 • 96 citations

Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells.

2002 • 96 citations

Statistical issues and methods for meta-analysis of microarray data: a case study in prostate cancer

2003 • 90 citations

Epithelial stem cells in human prostate growth and disease

2004 • 90 citations

HEPSIN inhibits cell growth/invasion in prostate cancer cells.

2002 • 89 citations

A Genome Screen of Families with Multiple Cases of Prostate Cancer: Evidence of Genetic Heterogeneity

2001 • 89 citations

Hepsin and Maspin are Inversely Expressed in Laser Capture Microdissectioned Prostate Cancer

2003 • 86 citations

Analysis of α-methylacyl-CoA racemase (P504S) expression in high-grade prostatic intraepithelial neoplasia

2004 • 85 citations

ANALYSIS OF PROSTATE CANCER BY PROTEOMICS USING TISSUE SPECIMENS

2005 • 82 citations

Histological markers of risk and the role of high-grade prostatic intraepithelial neoplasia

2001 • 82 citations

Mass Spectrometry-based Expression Profiling of Clinical Prostate Cancer

2005 • 78 citations

Inverse Relationship Between Skp2 Ubiquitin Ligase and the Cyclin Dependent Kinase Inhibitor p27 _Kip1 in Prostate Cancer

2003 • 77 citations

Prostatic neoplasia in transgenic mice with prostate-directed overexpression of the c-myc oncoprotein

2000 • 77 citations

Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer

2003 • 76 citations

Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A

2004 • 71 citations

Genome‐wide scan of Swedish families with hereditary prostate cancer: Suggestive evidence of linkage at 5q11.2 and 19p13.3

2003 • 69 citations

Polyamines and prostatic cancer

2003 • 66 citations

Loss of stearoyl‐CoA desaturase expression is a frequent event in prostate carcinoma

2004 • 64 citations

Neutral Endopeptidase Protein Expression and Prognosis in Localized Prostate Cancer

2004 • 64 citations

A NOVEL DIAGNOSTIC TEST FOR PROSTATE CANCER EMERGES FROM THE DETERMINATION OF α-METHYLACYL-COENZYME A RACEMASE IN PROSTATIC SECRETIONS

2004 • 64 citations

Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro.

2003 • 62 citations

Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk.

2002 • 60 citations

Bioinformatics Strategies for Translating Genome‐Wide Expression Analyses into Clinically Useful Cancer Markers

2004 • 58 citations

Emerging Roles for Hedgehog-Patched-Gli Signal Transduction in Reproduction1

2003 • 56 citations

Implantation-Dependent Expression of Trophinin by Maternal Fallopian Tube Epithelia during Tubal Pregnancies

2003 • 52 citations

High throughput screening of methylation status of genes in prostate cancer using an oligonucleotide methylation array

2004 • 50 citations

Serum levels of phytanic acid are associated with prostate cancer risk

2005 • 47 citations

ANALYSIS OF ANDROGEN REGULATED HOMEOBOX GENE NKX3.1 DURING PROSTATE CARCINOGENESIS

2004 • 44 citations

Molecular genetics of human prostate cancer

2004 • 44 citations

Inflammation-proliferation: possible relationships in the prostate.

1987 • 36 citations

Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate

2004 • 33 citations

Epidemiology and molecular biology of early prostatic neoplasia.

2000 • 30 citations

Predicting biochemical recurrence after radical prostatectomy for patients with organ-confined disease using p27 expression

2003 • 21 citations