THE BIOLOGY OF HORMONE REFRACTORY PROSTATE CANCER

Cancer statistics, 1998

1998 • 2,407 citations

In vivo amplification of the androgen receptor gene and progression of human prostate cancer

1995 • 1,464 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.

1994 • 940 citations

Bilateral Orchiectomy with or without Flutamide for Metastatic Prostate Cancer

1998 • 857 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.

1997 • 719 citations

Partial Hormone Resistance in Mice with Disruption of the Steroid Receptor Coactivator-1 (SRC-1) Gene

1998 • 685 citations

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

1993 • 597 citations

Etiology and disease process of benign prostatic hyperplasia

1989 • 557 citations

Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo.

1995 • 537 citations

Hormone-Induced Morphogenesis and Growth: Role of Mesenchymal–Epithelial Interactions

1983 • 441 citations

Activation of the Human Androgen Receptor through a Protein Kinase A Signaling Pathway

1996 • 430 citations

Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer

1996 • 421 citations

Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.

1993 • 421 citations

Differentiation pathways and histogenetic aspects of normal and abnormal prostatic growth: A stem cell model

1996 • 409 citations

Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.

1996 • 393 citations

Adaptation versus selection as the mechanism responsible for the relapse of prostatic cancer to androgen ablation therapy as studied in the Dunning R-3327-H adenocarcinoma.

1981 • 382 citations

Implication of cell kinetic changes during the progression of human prostatic cancer.

1995 • 345 citations

The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild‐type and androgen‐insensitive (Tfm) Mice

1978 • 304 citations

Distant metastases from prostatic carcinoma express androgen receptor protein.

1995 • 282 citations

The proliferative function of basal cells in the normal and hyperplastic human prostate

1994 • 251 citations

Androgens regulate vascular endothelial growth factor content in normal and malignant prostatic tissue.

1997 • 215 citations

Differential expression of keratins in the basal and luminal compartments of rat prostatic epithelium during degeneration and regeneration

1988 • 183 citations

Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone

1993 • 178 citations

Genetic instability coupled to clonal selection as a mechanism for tumor progression in the Dunning R-3327 rat prostatic adenocarcinoma system.

1982 • 171 citations

Basal cells are progenitors of luminal cells in primary cultures of differentiating human prostatic epithelium

1998 • 163 citations

Role of Androgens in Prostatic Cancer

1994 • 149 citations

Androgen receptor status of lymph node metastases from prostate cancer

1996 • 145 citations

Expression of bcl-2 and the progression of human and rodent prostatic cancers.

1996 • 139 citations

Potentiation of the antiangiogenic ability of linomide by androgen ablation involves down-regulation of vascular endothelial growth factor in human androgen-responsive prostatic cancers.

1997 • 102 citations

Chromosome aberrations in cultured cells deprived of single essential amino acids

1969 • 97 citations

The bcl-2 oncogene and apoptosis.

1992 • 90 citations

A Novel Coculture Model for Benign Prostatic Hyperplasia Expressing Both Isoforms of 5α-Reductase¹

1998 • 56 citations

Development of an androgen receptor-null model for identifying the initiation site for androgen stimulation of proliferation and suppression of programmed (apoptotic) death of PC-82 human prostate cancer cells.

1998 • 51 citations

Catalytic Cleavage of the Androgen Receptor Messenger RNA and Functional Inhibition of Androgen Receptor Activity by a Hammerhead Ribozyme

1998 • 47 citations

Androgen independence of primary epithelial cultures of the prostate is associated with a down-regulation of androgen receptor gene expression

1996 • 31 citations

A Novel Coculture Model for Benign Prostatic Hyperplasia Expressing Both Isoforms of 5 -Reductase

1998 • 23 citations

Partial androgen insensitivity caused by an androgen receptor mutation at amino acid 907 (Gly-->Arg) that results in decreased ligand binding affinity and reduced androgen receptor messenger ribonucleic acid levels.

1996 • 17 citations

Catalytic Cleavage of the Androgen Receptor Messenger RNA and Functional Inhibition of Androgen Receptor Activity by a Hammerhead Ribozyme

1998 • 15 citations

Partial androgen insensitivity caused by an androgen receptor mutation at amino acid 907 (Gly-->Arg) that results in decreased ligand binding affinity and reduced androgen receptor messenger ribonucleic acid levels

1996 • 10 citations