PTEN Up-Regulates the Tumor Metastasis Suppressor Gene Drg-1 in Prostate and Breast Cancer

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

2003 • 1,073 citations

Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems

1999 • 941 citations

Pten Dose Dictates Cancer Progression in the Prostate

2003 • 665 citations

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1998 • 654 citations

Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.

1998 • 453 citations

Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.

2003 • 416 citations

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway

2001 • 365 citations

High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.

2000 • 355 citations

Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN

2004 • 338 citations

Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer.

2002 • 318 citations

Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer.

2000 • 304 citations

The Drg-1 gene suppresses tumor metastasis in prostate cancer.

2003 • 301 citations

Loss of Expression of the PTEN Gene Protein Product Is Associated with Poor Outcome in Breast Cancer

2001 • 291 citations

PTEN, a unique tumor suppressor gene.

2000 • 266 citations

Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage.

1998 • 258 citations

A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms.

1997 • 252 citations

Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression

2004 • 187 citations

Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN

2001 • 118 citations

The phosphatidylinositol‐3 kinase pathway regulates bladder cancer cell invasion

2003 • 108 citations

Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells.

2002 • 96 citations

The differentiation‐related gene 1, Drg1, is markedly upregulated by androgens in LNCaP prostatic adenocarcinoma cells

1999 • 91 citations

PI3K Blockade by Ad-PTEN Inhibits Invasion and Induces Apoptosis in Radial Growth Phase and Metastatic Melanoma Cells

2002 • 82 citations

Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone

1997 • 75 citations

Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 gene

2001 • 70 citations

Localization of metastasis suppressor gene(s) for rat prostatic cancer to the long arm of human chromosome 10

1995 • 61 citations

PTEN expression is associated with prognosis for patients with advanced endometrial carcinoma undergoing postoperative chemotherapy

2002 • 57 citations