Myc confers androgen-independent prostate cancer cell growth

The development of androgen-independent prostate cancer

2001 • 2,285 citations

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1999 • 1,521 citations

MYC oncogenes and human neoplastic disease

1999 • 1,146 citations

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase

1999 • 983 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer.

2001 • 755 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Myc activates telomerase

1998 • 650 citations

Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy

1996 • 613 citations

Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.

1999 • 592 citations

From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

1999 • 587 citations

A history of prostate cancer treatment

2002 • 563 citations

Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor

2000 • 521 citations

Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization.

1995 • 490 citations

Identification of CDK4 as a target of c-MYC

2000 • 457 citations

Her-2-neu Expression and Progression Toward Androgen Independence in Human Prostate Cancer

2000 • 386 citations

Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.

1996 • 319 citations

c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points

1999 • 319 citations

Genetic Alterations in Hormone-Refractory Recurrent Prostate Carcinomas

1998 • 314 citations

Androgen receptor mutations in prostate cancer.

1996 • 301 citations

Mutation of the MXI1 gene in prostate cancer

1995 • 207 citations

Methylation and Inactivation of Estrogen, Progesterone, and Androgen Receptors in Prostate Cancer

2002 • 205 citations

Androgen Receptor Represses the Neuroendocrine Transdifferentiation Process in Prostate Cancer Cells

2003 • 164 citations

Abrogation by c-myc of Gl phase arrest induced by RB protein but not by p53

1992 • 99 citations

FISH Analysis of Gene Aberrations (MYC, CCND1, ERBB2, RB, and AR) in Advanced Prostatic Carcinomas Before and After Androgen Deprivation Therapy

2000 • 97 citations

Loss of heterozygosity and tumor suppressor activity ofBin1 in prostate carcinoma

2000 • 91 citations

Transcriptional regulation of prostate kallikrein-like genes by androgen.

1992 • 91 citations

Amplification of the androgen receptor gene in bone metastases from hormone‐refractory prostate cancer

2002 • 90 citations

Expression and Gene Copy Number Analysis of ERBB2 Oncogene in Prostate Cancer

2002 • 89 citations

Regressive changes and neuroendocrine differentiation in prostate cancer after neoadjuvant hormonal treatment

2000 • 86 citations

Androgen Regulation of c-myc Messenger Ribonucleic Acid Levels in Rat Ventral Prostate

1987 • 84 citations

Prostatic neoplasia in transgenic mice with prostate-directed overexpression of the c-myc oncoprotein

2000 • 77 citations

Androgen ablation promotes neuroendocrine cell differentiation in dog and human prostate

2002 • 75 citations

Fluorescence in situ hybridization evaluation of c-myc and androgen receptor gene amplification and chromosomal anomalies in prostate cancer in Japanese patients

2000 • 74 citations

Androgen induces differentiation of a human papillomavirus 16 E6/E7 immortalized prostate epithelial cell line

2001 • 68 citations

A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts

2000 • 63 citations

Neuroendocrine differentiated small cell carcinoma presenting as recurrent prostate cancer after androgen deprivation therapy

2001 • 55 citations

Amplification of the androgen receptor may not explain the development of androgen‐independent prostate cancer

2001 • 45 citations

ANDROGEN-INDUCED CELL GROWTH ANDC-MYCEXPRESSION IN HUMAN NON-TRANSFORMED EPITHELIAL PROSTATIC CELLS IN PRIMARY CULTURE

2001 • 39 citations

Effects of sex steroids on cell growth and C-myc oncogene expression in LN-CaP and DU-145 prostatic carcinoma cell lines

1995 • 12 citations