Supplying Copper to the Cuproenzyme Peptidylglycine α-Amidating Monooxygenase

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Methods in yeast genetics

1979 • 7,824 citations

[1] Getting started with yeast

1991 • 2,456 citations

Principles of bioinorganic chemistry

1995 • 1,638 citations

Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

1993 • 1,395 citations

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

1993 • 1,345 citations

Principles of bioinorganic chemistry

1995 • 976 citations

C<scp>ERULOPLASMIN</scp> M<scp>ETABOLISM AND</scp> F<scp>UNCTION</scp>

2002 • 850 citations

Overview of manual and automated DNA sequencing by the dideoxy chain termination method

1991 • 840 citations

The Role of Copper in Neurodegenerative Disease

1999 • 833 citations

The Copper Chaperone for Superoxide Dismutase

1997 • 828 citations

Metallochaperones, an Intracellular Shuttle Service for Metal Ions

2000 • 790 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

Metal Ion Chaperone Function of the Soluble Cu(I) Receptor Atx1

1997 • 675 citations

A Permease-Oxidase Complex Involved in High-Affinity Iron Uptake in Yeast

1996 • 666 citations

A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast

1988 • 592 citations

Structure of a yeast pheromone gene (MFα): A putative α-factor precursor contains four tandem copies of mature α-factor

1982 • 587 citations

The Biosynthesis Of Neuropeptides: Peptide Alpha-Amidation

1992 • 482 citations

Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae.

1984 • 477 citations

Biochemistry of Copper

1991 • 473 citations

CPx-type ATPases: a class of P-type ATPases that pump heavy metals

1996 • 472 citations

The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake.

1995 • 431 citations

The yeast Ca(2+)-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution.

1992 • 429 citations

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

1984 • 410 citations

The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake.

1994 • 407 citations

A Role for the Saccharomyces cerevisiae ATX1 Gene in Copper Trafficking and Iron Transport

1997 • 403 citations

Identification and Functional Expression of HAH1, a Novel Human Gene Involved in Copper Homeostasis

1997 • 372 citations

Biochemical Characterization of the Wilson Disease Protein and Functional Expression in the Yeast Saccharomyces cerevisiae

1997 • 324 citations

Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae.

1991 • 268 citations

A widespread transposable element masks expression of a yeast copper transport gene.

1996 • 248 citations

Localization of components involved in protein transport and processing through the yeast Golgi apparatus.

1991 • 247 citations

Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation

1998 • 225 citations

The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis

2001 • 220 citations

C-Terminal amidated peptides: Production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity

1994 • 219 citations

Saccharomyces cerevisiae Expresses Three Functionally Distinct Homologues of the Nramp Family of Metal Transporters

2000 • 213 citations

The Menkes copper transporter is required for the activation of tyrosinase

2000 • 213 citations

Brain Copper Content and Cuproenzyme Activity Do Not Vary with Prion Protein Expression Level

2000 • 196 citations

Negative Control of Heavy Metal Uptake by the Saccharomyces cerevisiae BSD2 Gene

1997 • 184 citations

Proteolytic Processing of Pro-ACTH/Endorphin Begins in the Golgi Complex of Pituitary Corticotropes and AtT-20 Cells

1989 • 165 citations

Restriction of Copper Export in Saccharomyces cerevisiae to a Late Golgi or Post-Golgi Compartment in the Secretory Pathway

1997 • 160 citations

Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase.

1999 • 160 citations

The Molecular Basis of Copper Homeostasis Copper-Related Disorders

2002 • 158 citations

Functional Expression of the Menkes Disease Protein Reveals Common Biochemical Mechanisms Among the Copper-transporting P-type ATPases

1998 • 158 citations

Topography of glycosylation in yeast: characterization of GDPmannose transport and lumenal guanosine diphosphatase activities in Golgi-like vesicles.

1989 • 154 citations

HAH1 Is a Copper-binding Protein with Distinct Amino Acid Residues Mediating Copper Homeostasis and Antioxidant Defense

1998 • 147 citations

Protein secretion from Saccharomyces cerevisiae directed by the prepro-alpha-factor leader region.

1986 • 144 citations

Structure-Function Analyses of the ATX1 Metallochaperone

1999 • 143 citations

A murine model of Menkes disease reveals a physiological function of metallothionein

1996 • 134 citations

The role of metals in neurodegenerative diseases.

2000 • 124 citations

Molecular cloning of the cDNA encoding laccase from Pycnoporus cinnabarinus I‐937 and expression in Pichia pastoris

2000 • 118 citations

Alternative mRNA splicing generates multiple forms of peptidyl-glycine alpha-amidating monooxygenase in rat atrium.

1989 • 116 citations

Expression of individual forms of peptidylglycine alpha-amidating monooxygenase in AtT-20 cells: endoproteolytic processing and routing to secretory granules

1992 • 113 citations

Prepro-alpha-factor has a cleavable signal sequence.

1988 • 99 citations

α-d-mannosidase of Saccharomyces cerevisiae Characterization and modulation of activity

1978 • 96 citations

Menkes Protein Contributes to the Function of Peptidylglycine α-Amidating Monooxygenase

2002 • 94 citations

Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease

1997 • 92 citations

Enzymatic formation of C-terminal amides

1999 • 90 citations

Mutation Analysis and Expression of the Mottled Gene in the Macular Mouse Model of Menkes Disease

1997 • 88 citations

Peptidylglycine α-Hydroxylating Monooxygenase: Active Site Residues, Disulfide Linkages, and a Two-Domain Model of the Catalytic Core

1997 • 84 citations

Intracellular Retention of Newly Synthesized Insulin in Yeast Is Caused by Endoproteolytic Processing in the Golgi Complex

2001 • 77 citations

Product of SEC53 is required for folding and glycosylation of secretory proteins in the lumen of the yeast endoplasmic reticulum.

1987 • 73 citations

Secretion of glycosylated human erythropoietin from yeast directed by the α-factor leader region

1989 • 60 citations

Incorporation of copper into lysyl oxidase

1997 • 47 citations

Secretion of somatostatin by Saccharomyces cerevisiae. Correct processing of an alpha-factor-somatostatin hybrid.

1986 • 39 citations

Cell Type-Specific Metabolism of Peptidylglycineα -Amidating Monooxygenase in Anterior Pituitary*

2000 • 32 citations

Targeting of Membrane Proteins to the Regulated Secretory Pathway in Anterior Pituitary Endocrine Cells

2001 • 30 citations

Structural and Functional Investigations on the Role of Zinc in Bifunctional Rat Peptidylglycine α-Amidating Enzyme

1997 • 28 citations

Differences in the Ways Sympathetic Neurons and Endocrine Cells Process, Store, and Secrete Exogenous Neuropeptides and Peptide-Processing Enzymes

1999 • 25 citations