Enzymatic formation of C-terminal amides

Principles and applications of organotransition metal chemistry

1980 • 1,561 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆II. Inhibition: Nomenclature and theory

1963 • 865 citations

Mechanisms Whereby Mononuclear Copper Proteins Functionalize Organic Substrates

1996 • 825 citations

Mechanism of C-terminal amide formation by pituitary enzymes

1982 • 658 citations

Chemical Characterization of a Family of Brain Lipids That Induce Sleep

1995 • 605 citations

The Biosynthesis Of Neuropeptides: Peptide Alpha-Amidation

1992 • 482 citations

Bioinorganic chemistry of copper

1994 • 459 citations

Amidation of Bioactive Peptides: The Structure of Peptidylglycine α-Hydroxylating Monooxygenase

1997 • 343 citations

Isotope effects on enzyme-catalyzed reactions

1992 • 323 citations

Peptide α-Amidation

1988 • 241 citations

The Sleep-inducing Lipid Oleamide Deconvolutes Gap Junction Communication and Calcium Wave Transmission in Glial Cells

1997 • 236 citations

Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.

1994 • 220 citations

GLYCINE N-ACYLASE: PURIFICATION AND PROPERTIES

1954 • 168 citations

Peptide Biosynthesis and Processing

1991 • 155 citations

Peptides in the Locusts, Locusta migratoria and Schistocerca gregaria

1997 • 153 citations

Mechanistic deductions from isotope effects in multireactant enzyme mechanisms

1981 • 142 citations

A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of .alpha.-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine .alpha.-amidating monooxygenase in peptide amidation

1990 • 138 citations

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase. Purification, characterization, and expression.

1991 • 128 citations

Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation.

1997 • 116 citations

Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase

1981 • 111 citations

Oxygen-18 kinetic isotope effects in the dopamine .beta.-monooxygenase reaction: Evidence for a new chemical mechanism in non-heme, metallomonooxygenase

1994 • 108 citations

The specificity of glycine-N-acylase and acylglycine excretion in the organicacidaemias

1974 • 107 citations

Secondary isotope effects and structure-reactivity correlations in the dopamine .beta.-monooxygenase reaction: evidence for a chemical mechanism

1985 • 105 citations

The Catalytic Core of Peptidylglycine .alpha.-Hydroxylating Monooxygenase: Investigation by Site-Directed Mutagenesis, Cu X-ray Absorption Spectroscopy, and Electron Paramagnetic Resonance

1995 • 104 citations

Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM).

1992 • 103 citations

Enzymatic peptidyl .alpha.-amidation proceeds through formation of an .alpha.-hydroxyglycine intermediate

1989 • 103 citations

Novel substrates and inhibitors of peptidylglycine .alpha.-amidating monooxygenase

1990 • 101 citations

Structural Investigations on the Coordination Environment of the Active-Site Copper Centers of Recombinant Bifunctional Peptidylglycine α-Amidating Enzyme

1996 • 88 citations

Peptidylglycine α-Hydroxylating Monooxygenase: Active Site Residues, Disulfide Linkages, and a Two-Domain Model of the Catalytic Core

1997 • 84 citations

Evidence for two copper atoms/subunit in dopamine beta-monooxygenase catalysis.

1984 • 80 citations

Kinetic Mechanism and Intrinsic Isotope Effects for the Peptidylglycine α-Amidating Enzyme Reaction

1998 • 77 citations

Kinetic and spectroscopic studies of the interaction of copper with dopamine beta-hydroxylase.

1984 • 76 citations

Selective reaction of glycine residues in hydrogen atom transfer from amino acid derivatives

1989 • 76 citations

Isolation of fatty acid amide as an angiogenic principle from bovine mesentery

1990 • 76 citations

Sequence similarity between dopamine β‐hydroxylase and peptide α‐amidating enzyme: Evidence for a conserved catalytic domain

1989 • 75 citations

Mechanism of modulation of dopamine .beta.-monooxygenase by pH and fumarate as deduced from initial rate and primary deuterium isotope effect studies

1983 • 75 citations

The Role of Secretory Granules in Peptide Biosynthesisa

1987 • 72 citations

Fatty Acid Amide Biosynthesis: A Possible New Role for Peptidylglycine α-Amidating Enzyme and Acyl-Coenzyme A:GlycineN-Acyltransferase

1996 • 69 citations

Purification and Characterization of a Peptidyl Glycine Monooxygenase from Porcine Pituitary*

1986 • 66 citations

Correlation of copper valency with product formation in single turnovers of dopamine .beta.-monooxygenase

1989 • 62 citations

Magnetic resonance studies on the mechanism of the enzymic β-hydroxylation of 3,4-dihydroxyphenylethylamine

1965 • 61 citations

Human peptidylglycine α-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells

1990 • 58 citations

Deduction of kinetic mechanism in multisubstrate enzyme reactions from tritium isotope effects. Application to dopamine beta-hydroxylase.

1980 • 58 citations

Bifunctional Peptidylglycine α-Amidating Enzyme Requires 2 Copper Atoms for Maximum Activity

1994 • 56 citations

Formation of peptide amides by peptidylglycine .alpha.-amidating monooxygenase: a new assay and stereochemistry of hydrogen loss

1988 • 55 citations

4‐Phenyl‐3‐butenoic acid, an in vivo inhibitor of peptidylglycine hydroxylase (peptide amidating enzyme)

1990 • 54 citations

The amidating enzyme in pituitary will accept a peptide with c-terminal d-alanine as substrate

1983 • 49 citations

Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9-A resolution.

1991 • 45 citations

Redox cycling of enzyme-bound copper during peptide amidation

1993 • 44 citations

3-Phenylpropenes as mechanism-based inhibitors of dopamine .beta.-hydroxylase: evidence for a radical mechanism

1985 • 44 citations

Peptides and growth factors in non-small cell lung cancer

1996 • 43 citations

Antiinflammatory and analgesic activity of an inhibitor of neuropeptide amidation.

1997 • 41 citations

Rapid freeze and chemical-quench studies of dopamine .beta.-monooxygenase: comparison of pre-steady-state and steady-state parameters

1989 • 40 citations

Oxygen-18 isotopic carbon-13 NMR shift as proof that bifunctional peptidylglycine .alpha.-amidating enzyme is a monooxygenase

1992 • 38 citations

Cloning and characterization of two alternatively spliced rat α-amidating enzyme cDNAs from rat medullary thyroid carcinoma

1990 • 38 citations

Mechanism-based inactivation of peptidylglycine .alpha.-hydroxylating monooxygenase (PHM) by a substrate analog, D-phenylalanyl-L-phenylalanyl-D-vinylglycine: inhibition of formation of peptide C-terminal amides

1992 • 37 citations

Design and kinetic characterization of multisubstrate inhibitors of dopamine .beta.-hydroxylase

1986 • 35 citations

Pyruvate-extended Amino Acid Derivatives as Highly Potent Inhibitors of Carboxyl-terminal Peptide Amidation

1997 • 34 citations

An ESR study of the acid dissociation of imidogen protons. 1. Linear peptide radicals and related radicals

1976 • 33 citations

Molecular Cloning of a Peptidylglycine α-Hydroxylating Monooxygenase from Sea Anemones

1997 • 33 citations

Kinetic and e.p.r. studies of cyanide and azide binding to the copper sites of dopamine (3,4-dihydroxyphenethylamine) β-mono-oxygenase

1984 • 33 citations

Structure-activity relationships for glycine-extended peptides and the α-amidating enzyme derived from medullary thyroid CA-77 cells

1988 • 32 citations

The source of the oxygen atom in the α-hydroxyglycine intermediate of the peptidylglycine α-amidating reaction

1992 • 32 citations

Molecular basis of protein function as determined by direct force measurements

1993 • 31 citations

Enhancement of Neovascularization in Regenerating Skeletal Muscle by the Sustained Release of Erucamide from a Polymer Matrix

1996 • 31 citations

Characterization of a bifunctional peptidylglycine α-amidating enzyme expressed in chinese hamster ovary cells

1992 • 29 citations

Multiple Forms of Peptidyl α-Amidating Enzyme: Purification from Rat Medullary Thyroid Carcinoma CA-77 Cell-Conditioned Medium

1989 • 28 citations

Structural and Functional Investigations on the Role of Zinc in Bifunctional Rat Peptidylglycine α-Amidating Enzyme

1997 • 28 citations

Inhibition of Peptidylglycine .alpha.-Amidating Monooxygenase by N-Substituted Homocysteine Analogs

1994 • 27 citations

Isolation and functional expression of pituitary peptidylglycine α‐amidating enzyme mRNA

1990 • 26 citations

Chemical stability and plasma-catalyzed dealkylation of peptidyl-α-hydroxyglycine derivatives—Intermediates in peptide α-amidation

1991 • 24 citations

The irreversible inactivation of two copper-dependent monooxygenases by sulfite: peptidylglycine α-amidating enzyme and dopamine β-monooxygenase

1995 • 21 citations

Peptide amidation in an invertebrate: Purification, characterization, and inhibition of peptidylglycine α‐hydroxylating monooxygenase from the heads of honeybees (apis mellifera)

1994 • 20 citations

Identification of the Five Essential Histidine Residues for Peptidylglycine Monooxygenase

1996 • 16 citations

Suppression of Substance P Biosynthesis in Sensory Neurons of Dorsal Root Ganglion by Prodrug Esters of Potent Peptidylglycine α-Amidating Monooxygenase Inhibitors

1997 • 16 citations

Human peptidylglycine α-amidating monooxygenase transcripts derived by alternative mRNA splicing of an unreported exon

1995 • 16 citations

Contribution of tunneling to secondary isotope effects in proton-transfer reactions

1984 • 16 citations

The Inactivation of Bifunctional Peptidylglycine α-Amidating Enzyme by Benzylhydrazine: Evidence That the Two Enzyme-Bound Copper Atoms Are Nonequivalent

1995 • 16 citations

Structure‐Activity Relationships among Inhibitors of Peptidylglycine Amidating Monooxygenase

1993 • 14 citations

Rapid fluorimetric assay for the detection of the peptidyl α-amdating enzyme intermediate using high-performance liquid chromatography

1992 • 12 citations