Restriction of Copper Export in Saccharomyces cerevisiae to a Late Golgi or Post-Golgi Compartment in the Secretory Pathway

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

1992 • 1,909 citations

The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

1993 • 1,905 citations

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

1980 • 1,808 citations

Principles of bioinorganic chemistry

1995 • 1,638 citations

Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

1993 • 1,395 citations

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

1993 • 1,345 citations

Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system.

1988 • 1,241 citations

Ligation-independent cloning of PCR products (LIC-PCR)

1990 • 1,161 citations

PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates.

1994 • 1,043 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

Principles of bioinorganic chemistry

1995 • 976 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

1992 • 832 citations

Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein

1993 • 720 citations

Isolation of a partial candidate gene for Menkes disease by positional cloning

1993 • 690 citations

A Permease-Oxidase Complex Involved in High-Affinity Iron Uptake in Yeast

1996 • 666 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport

1994 • 660 citations

The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake

1994 • 659 citations

Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking.

1996 • 623 citations

Measurement of Ceruloplasmin from Its Oxidase Activity in Serum by Use of o-Dianisidine Dihydrochloride

1974 • 595 citations

Aceruloplasminemia: molecular characterization of this disorder of iron metabolism.

1995 • 550 citations

Isolation and Characterization of a Human Liver cDNA as a Candidate Gene for Wilson Disease

1993 • 501 citations

Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.

1994 • 495 citations

CPx-type ATPases: a class of P-type ATPases that pump heavy metals

1996 • 472 citations

PROTEINASE MUTANTS OF SACCHAROMYCES CEREVISIAE

1977 • 460 citations

A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

1995 • 456 citations

The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake.

1995 • 431 citations

The role of ceruloplasmin in iron metabolism

1970 • 360 citations

Synaptic vesicle biogenesis, docking, and fusion: a molecular description

1996 • 349 citations

Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast.

1996 • 335 citations

Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes.

1994 • 258 citations

The FET3 Gene Product Required for High Affinity Iron Transport in Yeast Is a Cell Surface Ferroxidase

1995 • 242 citations

Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutase

1995 • 241 citations

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors

1993 • 239 citations

Biochemical characterization and intracellular localization of the Menkes disease protein

1996 • 205 citations

Role of Vacuolar Acidification in Protein Sorting and Zymogen Activation: a Genetic Analysis of the Yeast Vacuolar Proton-Translocating ATPase

1990 • 190 citations

Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane.

1995 • 183 citations

How MHC class II molecules reach the endocytic pathway.

1995 • 173 citations

The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.

1994 • 169 citations

Sequence, mapping and disruption of CCC2, a gene that cross‐complements the Ca²⁺‐sensitive phenotype of csg1 mutants and encodes a P‐type ATPase belonging to the Cu²⁺‐ATPase subfamily

1995 • 166 citations

The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization.

1995 • 157 citations

Secretory Granule Content Proteins and the Luminal Domains of Granule Membrane Proteins Aggregate in Vitro at Mildly Acidic pH

1996 • 155 citations

Acidification of endocytic compartments and the intracellular pathways of ligands and receptors

1984 • 136 citations

Vps1p, a member of the dynamin GTPase family, is necessary for Golgi membrane protein retention in Saccharomyces cerevisiae.

1993 • 132 citations

Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis.

1990 • 118 citations

The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast.

1993 • 103 citations

The vacuolar H+-ATPase of Saccharomyces cerevisiae is required for efficient copper detoxification, mitochondrial function, and iron metabolism

1993 • 102 citations

Protein transport to the yeast vacuole

1995 • 102 citations

A dominant trifluoperazine resistance gene from Saccharomyces cerevisiae has homology with F0F1 ATP synthase and confers calcium-sensitive growth.

1988 • 82 citations

A Putative Zinc Finger Protein, Saccharomyces cerevisiae Vpsl8p, Affects Late Golgi Functions Required for Vacuolar Protein Sorting and Efficient α-Factor Prohormone Maturation

1991 • 74 citations

Characterization of the END1 gene required for vacuole biogenesis and gluconeogenic growth of budding yeast.

1989 • 72 citations

Determinants of Ion Specificity on EF-hands Sites

1995 • 70 citations

Vacuolar biogenesis in yeast: Sorting out the sorting proteins

1995 • 69 citations

Separation of Fe⁺³ from transferrin in endocytosis

1983 • 54 citations

Guidebook to the secretory pathway

1994 • 42 citations

Vacuolar ATPase mutants accumulate precursor proteins in a pre-vacuolar compartment

1993 • 25 citations

Distribution of 64Cu in Saccharomyces cerevisiae: kinetic analyses of partitioning

1993 • 21 citations