A charged amino acid substitution within the transmembrane anchor of the Rous sarcoma virus envelope glycoprotein affects surface expression but not intracellular transport.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Studies on transformation of Escherichia coli with plasmids

1983 • 11,179 citations

A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels

1974 • 8,693 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Rapid Isolation of Antigens from Cells with A Staphylococcal Protein A-Antibody Adsorbent: Parameters of the Interaction of Antibody-Antigen Complexes with Protein A

1975 • 3,054 citations

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

Intracellular protein topogenesis

1980 • 1,378 citations

Sequence requirements for nuclear location of simian virus 40 large-T antigen

1984 • 1,278 citations

The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

1986 • 1,175 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

Nucleotide sequence of rous sarcoma virus

1983 • 901 citations

Transfer of Proteins Across Membranes

1981 • 894 citations

Energy of an Ion crossing a Low Dielectric Membrane: Solutions to Four Relevant Electrostatic Problems

1969 • 832 citations

A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-Å resolution

1982 • 710 citations

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

1984 • 652 citations

PROTEIN DEGRADATION IN CULTURED CELLS

1974 • 603 citations

A conformational preference parameter to predict helices in integral membrane proteins

1986 • 565 citations

Primary structure and transmembrane orientation of the murine anion exchange protein

1985 • 552 citations

Pre- and post-golgi vacuoles operate in the transport of semliki forest virus membrane glycoproteins to the cell surface

1984 • 523 citations

Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.

1984 • 513 citations

The Golgi Apparatus: Two Organelles in Tandem

1981 • 438 citations

Structure, organization, and somatic rearrangement of T cell gamma genes

1985 • 395 citations

The Phosphomannosyl Recognition System for Intracellular and Intercellular Transport of Lysosomal Enzymes

1982 • 379 citations

Path of the polypeptide in bacteriorhodopsin.

1980 • 366 citations

Ovalbumin: a secreted protein without a transient hydrophobic leader sequence.

1978 • 309 citations

Glycoproteins of the lysosomal membrane.

1985 • 294 citations

INHIBITION OF PHAGOCYTOSIS AND PLASMA MEMBRANE MOBILITY OF THE CULTIVATED MACROPHAGE BY CYTOCHALASIN B

1974 • 289 citations

The mechanism of protein secretion across membranes

1980 • 285 citations

Expression from cloned cDNA of cell-surface secreted forms of the glycoprotein of vesicular stomatitis virus in eucaryotic cells

1982 • 266 citations

A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function.

1978 • 266 citations

Altered cytoplasmic domains affect intracellular transport of the vesicular stomatitis virus glycoprotein

1983 • 264 citations

Subcellular compartmentalization of saccharide moieties in cultured normal and malignant cells.

1980 • 260 citations

Internalization and degradation of macrophage Fc receptors bound to polyvalent immune complexes.

1984 • 250 citations

Construction of influenza haemagglutinin genes that code for intracellular and secreted forms of the protein

1982 • 236 citations

Analysis of the distribution of charged residues in the N-terminal region of signal sequences: implications for protein export in prokaryotic and eukaryotic cells.

1984 • 230 citations

Cell-surface expression of influenza haemagglutinin from a cloned DNA copy of the RNA gene

1981 • 230 citations

Receptor-mediated endocytosis: coated pits, receptosomes and the Golgi

1983 • 225 citations

A transmembrane precursor of secretory component. The receptor for transcellular transport of polymeric immunoglobulins.

1982 • 220 citations

Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene.

1983 • 210 citations

An internal signal sequence: The asialoglycoprotein receptor membrane anchor

1986 • 209 citations

Passage of viral membrane proteins through the Golgi complex

1981 • 205 citations

A 70-kd protein of the yeast mitochondrial outer membrane is targeted and anchored via its extreme amino terminus.

1984 • 198 citations

Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds.

1984 • 189 citations

NH2-terminal hydrophobic region of influenza virus neuraminidase provides the signal function in translocation.

1984 • 156 citations

The transmembrane segment of the human transferrin receptor functions as a signal peptide.

1986 • 151 citations

Proteins Specified by Herpes Simplex Virus X. Staining and Radiolabeling Properties of B Capsid and Virion Proteins in Polyacrylamide Gels

1974 • 144 citations

Dissection of the Golgi complex. II. Density separation of specific Golgi functions in virally infected cells treated with monensin.

1983 • 144 citations

A stop transfer sequence confers predictable transmembrane orientation to a previously secreted protein in cell-free systems

1983 • 142 citations

Studies on the size, chemical composition, and partial sequence of the neuraminidase (NA) from type A influenza viruses show that the N-terminal region of the NA is not processed and serves to anchor the NA in the viral membrane

1982 • 134 citations

Subcellular Localization of Simian Virus 40 Large Tumor Antigen

1979 • 125 citations

Conversion of a secretory protein into a transmembrane protein results in its transport to the golgi complex but not to the cell surface

1984 • 120 citations

Complete sequence of the Rous sarcoma virus env gene: identification of structural and functional regions of its product

1983 • 119 citations

Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: I. Optimum conditions and minimum oligodeoxyribonucleotide length

1979 • 117 citations

Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes

1980 • 114 citations

Mutants of the Rous sarcoma virus envelope glycoprotein that lack the transmembrane anchor and cytoplasmic domains: analysis of intracellular transport and assembly into virions

1987 • 113 citations

Mutational Analysis of Simian Virus 40 T Antigen: Isolation and Characterization of Mutants with Deletions in the T-Antigen Gene

1983 • 112 citations

Degradation of the acetylcholine receptor in cultured muscle cells: Selective inhibitors and the fate of undegraded receptors

1980 • 111 citations

Mutations of the Rous sarcoma virus env gene that affect the transport and subcellular location of the glycoprotein products.

1984 • 109 citations

Selective Degradation of Abnormal Proteins in Mammalian Tissue Culture Cells

1974 • 109 citations

Expression and function of transplantation antigens with altered or deleted cytoplasmic domains

1983 • 105 citations

Restriction endonuclease and nucleotide sequence analyses of molecularly cloned unintegrated avian tumor virus DNA: structure of large terminal repeats in circle junctions

1982 • 104 citations

Processing of the rough endoplasmic reticulum membrane glycoproteins of rotavirus SA11.

1985 • 95 citations

Cell surface expression of the influenza virus hemagglutinin requires the hydrophobic carboxy-terminal sequences

1982 • 94 citations

Incorporation of a charged amino acid into the membrane-spanning domain blocks cell surface transport but not membrane anchoring of a viral glycoprotein.

1985 • 93 citations

Turnover of the plasma membrane proteins of hepatoma tissue culture cells.

1976 • 88 citations

Construction, expression and recognition of an H—2 molecule lacking its carboxyl terminus

1984 • 84 citations

Transmembrane orientation of glycoproteins encoded by the v-fms oncogene

1985 • 83 citations

The morphologic pathway of exocytosis of the vesicular stomatitis virus G protein in cultured fibroblasts

1982 • 81 citations

Rous sarcoma virus p19 and gp35 can be chemically crosslinked to high molecular weight complexes

1984 • 75 citations

Evidence That a Precursor Glycoprotein Is Cleaved to Yield the Major Glycoprotein of Avian Tumor Virus

1977 • 69 citations

A Transmembrane Precursor of Secretory Component

1983 • 62 citations

Expression of Semliki Forest virus proteins from cloned complementary DNA. II. The membrane-spanning glycoprotein E2 is transported to the cell surface without its normal cytoplasmic domain.

1983 • 61 citations

The 19-kDa glycoprotein coded by region E3 of adenovirus. Purification, characterization, and structural analysis.

1985 • 59 citations

Distinct carbohydrate components of influenza virus glycoproteins in smooth and rough cytoplasmic membranes

1973 • 58 citations

Structure and processing of the mouse mammary tumor virus glycoprotein precursor pr73env

1980 • 56 citations

Isolation of stable mouse cell lines that express cell surface and secreted forms of the vesicular stomatitis virus glycoprotein.

1983 • 55 citations

Mutants of the membrane-binding region of Semliki Forest virus E2 protein. I. Cell surface transport and fusogenic activity.

1986 • 54 citations

Intracellular Protein Topogenesis

1981 • 52 citations

Heterogeneous metabolism and subcellular localization of a potentially leukemogenic membrane glycoprotein encoded by Friend erythroleukemia virus. Isolation of viral and cellular processing mutants.

1982 • 52 citations

Synthesis and processing of avian sarcoma virus glycoproteins

1978 • 44 citations

Cell killing by simian virus 40: impairment of membrane formation and function

1977 • 42 citations

Incorporation of a Charged Amino Acid into the Membrane-Spanning Domain Blocks Cell Surface Transport But Not Membrane Anchoring of a Viral Glycoprotein

1985 • 41 citations

Glycosylation and surface expression of the influenza virus neuraminidase requires the N-terminal hydrophobic region.

1984 • 40 citations

Processing of gPr92env, the precursor to the glycoproteins of rous sarcoma virus: Use of inhibitors of oligosaccharide trimming and glycoprotein transport

1984 • 35 citations

Membrane traffic in animal cells

1984 • 33 citations

Alterations in the transport and processing of Rous sarcoma virus envelope glycoproteins mutated in the signal and anchor regions

1983 • 26 citations

Oligosaccharide Chains of Avian RNA Tumor Virus Glycoproteins Contain Heterogeneous Oligomannosyl Cores

1979 • 23 citations

A weakly pathogenic Rauscher spleen focus-forming virus mutant that lacks the carboxyl-terminal membrane anchor of its envelope glycoprotein

1985 • 21 citations

The structure of the Rous sarcoma virus glycoprotein complex

1978 • 19 citations

Oligosaccharide modifications and the site of processing of gPr92env, the precursor for the viral glycoproteins of rous sarcoma virus

1982 • 19 citations

Glycosylation and Surface Expression of the Influenza Virus Neuraminidase Requires the N-Terminal Hydrophobic Region

1984 • 17 citations

Temperature-dependent internalization of virus glycoproteins in cells infected with a mutant of Semliki Forest virus.

1982 • 10 citations