Analysis of the distribution of charged residues in the N-terminal region of signal sequences: implications for protein export in prokaryotic and eukaryotic cells.

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites

1983 • 2,290 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides

1983 • 1,143 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor

1983 • 751 citations

How signal sequences maintain cleavage specificity

1984 • 725 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27

1983 • 664 citations

Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development

1983 • 645 citations

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 644 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Structure of the human immune interferon gene

1982 • 510 citations

The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains

1984 • 507 citations

Molecular cloning of cDNA for murine interleukin-3

1984 • 485 citations

Molecular Basis of Herbicide Resistance in Plants in Amaranthus hybridus

1983 • 477 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Cloning and sequence analysis of a cDNA encoding rat preprocholecystokinin.

1984 • 355 citations

Mechanism of Incorporation of Cell Envelope Proteins in Escherichia Coli

1982 • 344 citations

Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish

1980 • 337 citations

A single gene encodes multiple neuropeptides mediating a stereotyped behavior

1983 • 312 citations

Herpes Simplex Virus Type-1 Glycoprotein D Gene: Nucleotide Sequence and Expression inEscherichia coli

1982 • 285 citations

Mechanisms of protein localization

1983 • 282 citations

Human leukocyte and fibroblast interferons are structurally related

1980 • 273 citations

Isolation and characterization of the human apolipoprotein A-I gene.

1983 • 243 citations

Detailed analysis of the portion of the herpes simplex virus type 1 genome encoding glycoprotein C

1983 • 230 citations

Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld.

1982 • 223 citations

Complete nucleotide sequence of a French bean storage protein gene: Phaseolin

1983 • 218 citations

Effects of the complete removal of basic amino acid residues from the signal peptide on secretion of lipoprotein in Escherichia coli.

1983 • 214 citations

Gene sequence of the λ receptor, an outer membrane protein of E. coli K12

1981 • 211 citations

Complete amino acid sequence of mouse pro-opiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA.

1983 • 207 citations

Isolation and sequence analysis of a barley alpha-amylase cDNA clone.

1983 • 201 citations

Angiotensinogen Is Related to the Antitrypsin-Antithrombin-Ovalbumin Family

1983 • 194 citations

Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains.

1984 • 190 citations

Cloning and sequence analysis of cDNA for ovine corticotropin-releasing factor precursor

1983 • 170 citations

The biosynthesis and primary structure of pea seed lectin.

1983 • 169 citations

Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin.

1983 • 169 citations

Nucleotide sequence of a cloned structural gene coding for a precursor of pancreatic somatostatin.

1980 • 163 citations

Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene.

1983 • 162 citations

Complete primary structures of the E beta chain and gene of the mouse major histocompatibility complex.

1983 • 161 citations

Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation

1983 • 160 citations

Membrane-bound penicillinases in Gram-positive bacteria.

1982 • 142 citations

Rat apolipoprotein E mRNA. Cloning and sequencing of double-stranded cDNA.

1983 • 137 citations

Homology between the primary structure of α-fetoprotein, deduced from a complete cDNA sequence, and serum albumin

1981 • 129 citations

Nucleotide Sequence of a Light Chain Gene of the Mouse I-A Subregion: Aβ ^d

1983 • 127 citations

Gene and protein structure of a β-crystallin polypeptide in murine lens: relationship of exons and structural motifs

1983 • 121 citations

Nucleotide Sequence and Expression of the Diphtheria tox 228 Gene in Escherichia coli

1983 • 120 citations

Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin.

1983 • 95 citations

Complete nucleotide sequence of the gene for the specific glycoprotein (gp55) of Friend spleen focus-forming virus.

1983 • 93 citations

The complete nucleotide sequence of the I-Eα^dimmune response gene

1983 • 90 citations

DNA sequence coding for an antifreeze protein precursor from winter flounder.

1982 • 89 citations

Sequence of a cDNA encoding pancreatic preprosomatostatin-22.

1982 • 82 citations

Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genes

1978 • 80 citations

Cloning and sequencing of the preprotoxin-coding region of the yeast M1 double-stranded RNA.

1984 • 80 citations

Evidence for a coupling of synthesis and export of an outer membrane protein in Escherichia coli.

1983 • 78 citations

The heavy chain of human B-cell alloantigen HLA-DS has a variable N-terminal region and a constant immunoglobulin-like region

1983 • 74 citations

Primary structures of bovine liver low molecular weight kininogen precursors and their two mRNAs.

1983 • 67 citations

Nucleotide and amino acid sequence comparisons of preprosomatostatins.

1983 • 62 citations

Molecular components of the signal sequence that function in the initiation of protein export.

1982 • 61 citations

Somatic Mutation in Genes for the Variable Portion of the Immunoglobulin Heavy Chain

1982 • 60 citations

Seminal vesicle secretion IV gene: allelic difference due to a series of 20-base-pair direct tandem repeats within an intron.

1983 • 55 citations

Isolation and analysis of genomic DNA clones encoding the third component of mouse complement.

1982 • 51 citations

Removal of formyl-methionine residue from nascent bacteriophage f2 protein

1972 • 51 citations

Comparison of the lipoprotein gene among the Enterobacteriaceae. DNA sequence of Erwinia amylovora lipoprotein gene.

1981 • 50 citations

Signal sequence mutations disrupt feedback between secretion of an exported protein and its synthesis in E. coli

1984 • 46 citations

Kinetics of maturation of the amino termini of the cell proteins of Escherichia coli

1969 • 39 citations

A cDNA sequence encoding a rabbit heavy chain variable region of the VHa2 allotype showing homologies with human heavy chain sequences

1982 • 33 citations

Isolation of two genomic sequences encoding the Mr = 14,000 subunit of rat prostatein.

1983 • 29 citations

The nucleotide sequences defining the signal peptides of the galactose-binding protein and the arabinose-binding protein.

1983 • 21 citations