Structure, organization, and somatic rearrangement of T cell gamma genes

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

The structure and evolution of the human β-globin gene family

1980 • 1,398 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

A simple method for DNA restriction site mapping

1976 • 1,025 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

1984 • 652 citations

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

1984 • 528 citations

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody.

1982 • 526 citations

Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo

1984 • 520 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

A third type of murine T-cell receptor gene

1984 • 491 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

EK2 Derivatives of Bacteriophage Lambda Useful in the Cloning of DNA from Higher Organisms: The λgt WES System

1977 • 415 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene

1984 • 410 citations

Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide

1984 • 407 citations

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

1984 • 389 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

1978 • 353 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes

1981 • 314 citations

The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

1984 • 306 citations

The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor

1984 • 290 citations

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

1982 • 278 citations

Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus

1984 • 274 citations

The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumors

1983 • 264 citations

The mouse T cell receptor: Structural heterogeneity of molecules of normal T cells defined by Xenoantiserum

1983 • 217 citations

The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: Identification of constant and variable peptides

1983 • 209 citations

The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

1984 • 204 citations

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

1984 • 183 citations

The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity.

1983 • 181 citations

SEQ: a nucleotide sequence analysis and recombination system

1982 • 179 citations

Identification of the Receptor for Antigen and Major Histocompatibility Complex on Human Inducer T Lymphocytes

1983 • 165 citations

Localization of a T-cell receptor diversity-region element

1984 • 159 citations

A one-receptor view of T-cell behaviour

1981 • 146 citations

Diversity of germ-line immunoglobulin VH genes

1981 • 140 citations

Factors governing the expression of a bacterial gene in mammalian cells.

1981 • 126 citations

Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups.

1983 • 122 citations

Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains.

1984 • 117 citations

Purification and NH2-terminal amino acid sequencing of the beta subunit of a human T-cell antigen receptor.

1984 • 99 citations

Gene segments encoding transmembrane carboxyl termini of immunoglobulin γ chains

1981 • 99 citations

Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis.

1982 • 95 citations

T-cell inhibition of humoral responsiveness

1978 • 86 citations

Immunoglobulin-like nature of the α-chain of a human T-cell antigen/MHC receptor

1984 • 83 citations

A Dual Recognition Model for Cytotoxic T Cells Based on Thymic Selection of Precursors with Low Affinity for Self H‐2 Antigens

1978 • 77 citations

mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain.

1982 • 68 citations

Murine T cell receptor beta chain is encoded on chromosome 6.

1984 • 51 citations

Monoclonal antibodies specific for a murine cytotoxic T-lymphocyte clone.

1984 • 51 citations

Diversity at the variable-joining region boundary of lambda light chains has a pronounced effect on immunoglobulin ligand-binding activity.

1984 • 36 citations