Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)

1995 • 6,935 citations

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

2000 • 2,569 citations

A molecular signature of metastasis in primary solid tumors

2002 • 2,424 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

The snail superfamily of zinc-finger transcription factors

2002 • 1,665 citations

Notch signaling is essential for vascular morphogenesis in mice

2000 • 1,042 citations

Notch1 functions as a tumor suppressor in mouse skin

2003 • 957 citations

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

2001 • 876 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells

2000 • 715 citations

Molecular Regulation of Atrioventricular Valvuloseptal Morphogenesis

1995 • 642 citations

A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

1992 • 637 citations

Transforming Growth Factor β-1 Induces Snail Transcription Factor in Epithelial Cell Lines

2003 • 617 citations

Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A)

1990 • 616 citations

The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition

2001 • 611 citations

Fringe modulates Notch–ligand interactions

1997 • 578 citations

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

2002 • 577 citations

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

2002 • 551 citations

The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition

1997 • 515 citations

Chamber-Specific Cardiac Expression of Tbx5 and Heart Defects in Holt–Oram Syndrome

1999 • 501 citations

A γ‐secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

2002 • 493 citations

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

1994 • 483 citations

Disruption of the mouse RBP-Jк gene results in early embryonic death

1995 • 478 citations

Structural development of endocardial cushions

1977 • 468 citations

Vasculogenesis in the day 6.5 to 9.5 mouse embryo

2000 • 437 citations

Notch signalling and the control of cell fate choices in vertebrates

1998 • 410 citations

Defects in somite formation in lunatic fringe-deficient mice

1998 • 405 citations

Zebrafish genetics and vertebrate heart formation

2001 • 403 citations

lunatic fringe is an essential mediator of somite segmentation and patterning

1998 • 395 citations

The Wnt/β-catenin pathway regulates cardiac valve formation

2003 • 389 citations

Metastasis is driven by sequential elevation of H-ras and Smad2 levels

2002 • 365 citations

Activation of Notch signaling pathway precedes heart regeneration in zebrafish

2003 • 329 citations

Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2–ErbB3 receptors

2002 • 327 citations

Periodic Notch inhibition by Lunatic Fringe underlies the chick segmentation clock

2003 • 326 citations

Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)-β and bone morphogenetic protein (BMP)

2000 • 310 citations

Delta4, an endothelial specific Notch ligand expressed at sites of physiological and tumor angiogenesis

2001 • 298 citations

The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation

1997 • 290 citations

UDP-Glucose Dehydrogenase Required for Cardiac Valve Formation in Zebrafish

2001 • 277 citations

HRT1, HRT2, and HRT3: A New Subclass of bHLH Transcription Factors Marking Specific Cardiac, Somitic, and Pharyngeal Arch Segments

1999 • 276 citations

Temporal and Distinct TGFβ Ligand Requirements during Mouse and Avian Endocardial Cushion Morphogenesis

2002 • 273 citations

Invasion of mesenchyme into three-dimensional collagen gels: A regional and temporal analysis of interaction in embryonic heart tissue

1983 • 265 citations

Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development

1992 • 253 citations

GATA-5: A Transcriptional Activator Expressed in a Novel Temporally and Spatially-Restricted Pattern during Embryonic Development

1997 • 253 citations

Inhibition of integrin linked kinase (ILK) suppresses β-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC−/− human colon carcinoma cells

2001 • 243 citations

Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse

1999 • 242 citations

TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis

1990 • 239 citations

Expression analysis of a Notch homologue in the mouse embryo

1992 • 230 citations

Notch: a membrane-bound transcription factor

2002 • 223 citations

SnailprecedesSlugin the genetic cascade required for the specification and migration of theXenopusneural crest

2003 • 221 citations

Notch and Neurogenesis

2018 • 200 citations

Notch signaling in the development of the inner ear: Lessons from Drosophila

2000 • 186 citations

Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development

2002 • 182 citations

Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart

1998 • 180 citations

Slug is an Essential Target of TGFβ2 Signaling in the Developing Chicken Heart

2000 • 180 citations

Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene

1992 • 178 citations

Notch activity inducesNodalexpression and mediates the establishment of left–right asymmetry in vertebrate embryos

2003 • 178 citations

RNA and protein localisations of TGFβ2 in the early mouse embryo suggest an involvement in cardiac development

1993 • 166 citations

Overexpression of a zebrafish homologue of the Drosophila neurogenic gene Delta perturbs differentiation of primary neurons and somite development

1997 • 132 citations

The Vascular Endothelial-Cadherin Promoter Directs Endothelial-Specific Expression in Transgenic Mice

1999 • 118 citations

Genetic Assembly of the Heart: Implications for Congenital Heart Disease

2001 • 106 citations

REGULATION OF T CELL FATE BY NOTCH

1999 • 105 citations

3 Segmentation of the Paraxial Mesoderm and Vertebrate Somitogenesis

1999 • 58 citations

TGFβ Type III and TGFβ Type II receptors have distinct activities during epithelial–mesenchymal cell transformation in the embryonic heart

2001 • 45 citations