Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Glutamate receptor ion channels

2005 • 3,667 citations

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Excitotoxic cell death

1992 • 2,307 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Staging of alzheimer's disease-related neurofibrillary changes

1995 • 2,187 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

1998 • 1,795 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

1988 • 1,533 citations

Greenfield's Neuropathology

1964 • 1,429 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Excitatory amino acid receptors in the vertebrate central nervous system.

1989 • 1,316 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

The Time Course of Glutamate in the Synaptic Cleft

1992 • 1,071 citations

N-methyl-D-aspartic acid receptor structure and function

1994 • 989 citations

Polyamines: Mysterious Modulators of Cellular Functions

2000 • 858 citations

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

1987 • 852 citations

Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data

1999 • 841 citations

Staging of Alzheimer-Related Cortical Destruction

1993 • 810 citations

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

1992 • 805 citations

Cooperative Modulation of [³H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines

1988 • 755 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

Metabolism and role of glutamate in mammalian brain

1990 • 669 citations

Structure and function of the NMDA receptor channel

1995 • 645 citations

The natural polyamine spermine functions directly as a free radical scavenger

1998 • 644 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors

1997 • 629 citations

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

1998 • 621 citations

Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor

1993 • 605 citations

Alternative excitotoxic hypotheses

1992 • 572 citations

Memantine in severe dementia: results of the9M-best study (benefit and efficacy in severly demented patients during treatment with memantine)

1999 • 532 citations

Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing

1992 • 521 citations

Differential expression of five N‐methyl‐D‐aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats

1994 • 463 citations

Selective modulation of NMDA responses by reduction and oxidation

1989 • 459 citations

Modulation of the N-methyl-D-aspartate channel by extracellular H+.

1990 • 458 citations

Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc

1994 • 445 citations

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

1988 • 437 citations

Glutamate receptor channels: novel properties and new clones

1992 • 427 citations

Control of Proton Sensitivity of the NMDA Receptor by RNA Splicing and Polyamines

1995 • 395 citations

Ligand affinities at recombinant receptors depend on subunit composition

1994 • 381 citations

The glial cell glutamate uptake carrier countertransports pH-changing anions

1992 • 372 citations

Neuritic pathology and dementia in alzheimer's disease

1991 • 362 citations

New Perspectives on Alzheimer's Disease

1986 • 349 citations

Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C.

1993 • 347 citations

Alterations in L-Glutamate Binding in Alzheimer's and Huntington's Diseases

1985 • 334 citations

Synaptic targets of HRP-filled layer III pyramidal cells in the cat striate cortex

1986 • 324 citations

N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.

1987 • 309 citations

Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons

1990 • 302 citations

Cortical neuronal counts in normal elderly controls and demented patients

1983 • 293 citations

Dementia of the Alzheimer's Type: Changes in Hippocampal L‐[³H]Glutamate Binding

1987 • 281 citations

The role of polyamine catabolism in polyamine analogue-induced programmed cell death

1997 • 278 citations

Methods for antagonizing glutamate neurotoxicity.

1990 • 277 citations

Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones.

1989 • 275 citations

Neuroprotection by memantine against neurodegeneration induced by β-amyloid(1–40)

2002 • 266 citations

NMDA receptor channels: Subunit-specific potentiation by reducing agents

1994 • 263 citations

Control of Voltage-Independent Zinc Inhibition of NMDA Receptors by the NR1 Subunit

1998 • 263 citations

Ketamine and phencyclidine cause a voltage-dependent block of responses to l-aspartic acid

1985 • 261 citations

Brain S‐Adenosylmethionine Levels Are Severely Decreased in Alzheimer's Disease

1996 • 261 citations

Subtype-Dependence of NMDA Receptor Channel Open Probability

1999 • 259 citations

Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor

1994 • 251 citations

Anatomy and physiology of glutamate in the CNS.

1994 • 242 citations

Brain Edema: Induction in Cortical Slices by Polyunsaturated Fatty Acids

1978 • 242 citations

Aminergic systems in Alzheimer's disease and Parkinson's disease

1987 • 241 citations

Trapping Channel Block of NMDA-Activated Responses By Amantadine and Memantine

1997 • 237 citations

Biochemical and molecular studies using human autopsy brain tissue

2003 • 230 citations

Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site.

1989 • 224 citations

Pharmacological properties and H+ sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones.

1991 • 221 citations

Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits.

1994 • 219 citations

Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease

1986 • 215 citations

Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.

1989 • 215 citations

Polyamines Differentially Modulate the Transcription of Growth-associated Genes in Human Colon Carcinoma Cells

1989 • 211 citations

Differential Sensitivity of RecombinantN-Methyl-d-Aspartate Receptor Subtypes to Zinc Inhibition

1997 • 210 citations

Multiple effects of spermine on N‐methyl‐D‐aspartic acid receptor responses of rat cultured hippocampal neurones.

1993 • 199 citations

Tricyclic antidepressants block N‐methyl‐D‐aspartate receptors: similarities to the action of zinc

1988 • 189 citations

Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

1995 • 187 citations

Voltage-dependent block by intracellular Mg2+ of N-methyl-D-aspartate-activated channels

1990 • 186 citations

Progressive degeneration of nonphosphorylated neurofilament protein‐enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: Stereologic analysis of prefrontal cortex area 9

2003 • 184 citations

Both NMDA and non-NMDA subtypes of glutamate receptors are concentrated at synapses on cerebral cortical neurons in culture

1991 • 172 citations

N‐Methyl‐d‐Aspartate‐Sensitive Glutamate Receptors Induce Calcium‐Mediated Arachidonic Acid Release in Primary Cultures of Cerebellar Granule Cells

1990 • 171 citations

The inhibition of single N‐methyl‐D‐aspartate‐activated channels by zinc ions on cultured rat neurones.

1990 • 170 citations

Interactions of polyamines with neuronal ion channels

1993 • 158 citations

Vicious Cycle Involving Na⁺Channels, Glutamate Release, and NMDA Receptors Mediates Delayed Neurodegeneration through Nitric Oxide Formation

1996 • 154 citations

A Regulatory Domain (R1–R2) in the Amino Terminus of theN-Methyl-d-Aspartate Receptor: Effects of Spermine, Protons, and Ifenprodil, and Structural Similarity to Bacterial Leucine/Isoleucine/Valine Binding Protein

1999 • 153 citations

N-Methyl-d-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer’s disease

2001 • 148 citations

Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors

1995 • 143 citations

The NMDA receptor complex

1993 • 139 citations

Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type

1989 • 136 citations

AN ELECTRON MICROSCOPIC STUDY OF THE TYPES AND PROPORTIONS OF NEURONS IN THE CORTEX OF THE MOTOR AND VISUAL AREAS OF THE CAT AND RAT

1980 • 134 citations

Intracellular calcium levels during the period of delayed excitotoxicity

1993 • 132 citations

Glutamate in rat brain cortex synaptic vesicles: influence of the vesicle isolation procedure

1986 • 128 citations

β-Amyloid selectively augments NMDA receptor-mediated synaptic transmission in rat hippocampus

1995 • 126 citations

Brain polyamine levels are altered in Alzheimer's disease

1995 • 125 citations

The Ca²⁺ influx induced by β‐amyloid peptide 25–35 in cultured hippocampal neurons results from network excitation

1995 • 123 citations

NMDA Receptor Pharmacology: Perspectives from Molecular Biology

2001 • 122 citations

Glycine-independent and subunit-specific potentiation of NMDA responses by extracellular Mg2+

1995 • 119 citations

Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease

1987 • 119 citations

The polyamine spermine has multiple actions on N-methyl-D-aspartate receptor single-channel currents in cultured cortical neurons.

1992 • 118 citations

Reduced Glycine Stimulation of [³H]MK‐801 Binding in Alzheimer's Disease

1989 • 117 citations

Spermine potentiation of recombinant N-methyl-D-aspartate receptors is affected by subunit composition.

1994 • 112 citations

Selective increase of NMDA-sensitive glutamate binding in the striatum of Parkinson's disease, Alzheimer's disease, and mixed Parkinson's disease/Alzheimer's disease patients: an autoradiographic study

1994 • 107 citations

Memantine restores long term potentiation impaired by tonic N-methyl-d-aspartate (NMDA) receptor activation following reduction of Mg2+ In hippocampal slices

1999 • 106 citations

Exon 5 and Spermine Regulate Deactivation of NMDA Receptor Subtypes

2000 • 103 citations

Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias.

1990 • 100 citations

Identification of a High Affinity Divalent Cation Binding Site near the Entrance of the NMDA Receptor Channel

1996 • 99 citations

[3H]MK-801 binding to the NMDA receptor complex, and its modulation in human frontal cortex during development and aging

1992 • 98 citations

Aged Non‐Human Primates: An Animal Model of Age‐Associated Neurodegenerative Disease

1991 • 97 citations

Loss of hippocampal [3H]TCP binding in Alzheimer's disease

1987 • 97 citations

Neurochemical Studies of Alzheimer's Disease

1996 • 96 citations

Spermine and related polyamines produce a voltage-dependent reduction of N-methyl-D-aspartate receptor single-channel conductance.

1992 • 96 citations

Polyamine metabolism in different pathological states of the brain

1992 • 95 citations

The Involvement of NMDA Receptors in Acute and Chronic Effects of Ethanol

1992 • 92 citations

Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. I. CA1 of hippocampus

1991 • 92 citations

Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death

1991 • 91 citations

Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. II. Subiculum

1991 • 90 citations

Biochemical properties of the brain phencyclidine receptor

1982 • 86 citations

Relationship between plaques, tangles, and dystrophic processes in Alzheimer's disease

1995 • 85 citations

Role of spermine in amyloid ?-peptide-associated free radical-induced neurotoxicity

2001 • 85 citations

Polyamine transport, accumulation, and release in brain

2003 • 85 citations

Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease

1988 • 85 citations

[3H]TCP binding sites in Alzheimer's disease

1987 • 83 citations

Excitatory transmitter neurotoxicity

1994 • 82 citations

On the Subcellular Localization of the Polyamines

1989 • 78 citations

Interactions between spermine and Mg2+ on mitochondrial Ca2+ transport.

1986 • 76 citations

Ornithine Decarboxylase in Human Brain: Influence of Aging, Regional Distribution, and Alzheimer's Disease

1998 • 74 citations

NMDA Receptor as a Mediator of Activity-dependent Synaptogenesis in the Developing Brain

1990 • 73 citations

The entry of [1-13C]glucose into biochemical pathways reveals a complex compartmentation and metabolite trafficking between glia and neurons: a study by 13C-NMR spectroscopy

1997 • 73 citations

Homomeric assemblies of NMDAR1 splice variants are sensitive to ethanol

1993 • 71 citations

Cellular control of ornithine decarboxylase activity by its antizyme

1981 • 70 citations

Different Mechanisms of Ca2+ Transport in NMDA and Ca2+-permeable AMPA Glutamate Receptor Channels

1998 • 70 citations

Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.

1996 • 69 citations

An acidic amino acid in the N-methyl-D-aspartate receptor that is important for spermine stimulation.

1995 • 69 citations

Glutamate_NMDA receptor NR1 subunit mRNA expression in Alzheimer's disease

2001 • 66 citations

Neurochemical aspects of the receptor complex

1991 • 65 citations

Loss of glycine-dependent radioligand binding to the receptor complex in patients with Alzheimer's disease

1989 • 63 citations

AGE‐RELATED VARIATIONS IN THE NEURON CONTENT OF THE CEREBRAL CORTEX IN SENILE DEMENTIA OF ALZHEIMER TYPE

1985 • 62 citations

The NR2B-specific Interactions of Polyamines and Protons with theN-Methyl-d-aspartate Receptor

1997 • 62 citations

An Overview of the Etiology, Diagnosis, and Treatment of Alzheimer Disease

1998 • 60 citations

Inhibition by spermine of the inner membrane permeability transition of isolated rat heart mitochondria

1992 • 59 citations

Neuroexcitation, excitotoxicity and human neurological disease.

1993 • 59 citations

Distribution of Glutamate Receptor Subunit NMDAR1 in the Hippocampus of Normal Elderly and Patients with Alzheimer's Disease

1999 • 56 citations

Is senile dementia of the Alzheimer type associated with hippocampal plasticity?

1988 • 56 citations

Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease

2004 • 54 citations

Excited to death: different ways to lose your neurones.

2002 • 53 citations

Clinical symptoms associated with age at onset in Alzheimer's disease

1994 • 51 citations

Decreased expression of N-methyl-d-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain

1997 • 50 citations

The stage specific temporal course of Alzheimer's disease: functional and behavioral concomitants based upon cross-sectional and longitudinal observation.

1989 • 50 citations

Regulation of polyamine biosynthesis by antizyme and some recent developments relating the induction of polyamine biosynthesis to cell growth

1985 • 49 citations

Genes and susceptible loci of Alzheimer’s disease

1999 • 48 citations

Enflurane inhibits NMDA, AMPA, and kainate‐induced currents in Xenopus oocytes expressing mouse and human brain mRNA

1993 • 48 citations

Cloning and structure of the gene encoding the human N-methyl-d-aspartate receptor (NMDAR1)

1995 • 47 citations

The N-methyl-d-aspartate receptor complex in Alzheimer's disease: reduced regulation by glycine but not zinc

1989 • 44 citations

[3H]MK-801 binding in Alzheimer's disease

1988 • 44 citations

Spermine and Arcaine Block and Permeate N-Methyl-d-Aspartate Receptor Channels

1999 • 43 citations

Glutamate Receptors Form Hot Spots on Apical Dendrites of Neocortical Pyramidal Neurons

2001 • 43 citations

Calcium Binds Dynamin I and Inhibits Its GTPase Activity

1996 • 39 citations

Role of calcium in the modulation of ornithine decarboxylase activity in isolated pig granulosa cells in vitro

1981 • 37 citations

Animal and drug modelling for Alzheimer synaptic pathology

1992 • 37 citations

Functional Characterization of Human N‐Methyl‐<scp>d</scp>‐Aspartate Subtype 1A/2D Receptors

1998 • 36 citations

[³H]N‐[1‐(2‐Thienyl)cyclohexyl]‐3,4‐Piperidine ([³H]TCP) Binding in Human Frontal Cortex: Decreases in Alzheimer‐Type Dementia

1990 • 35 citations

Dual effect of spermine on mitochondrial Ca2+ transport

1992 • 35 citations

Laminar distribution of neuritic plaques in normal aging, Alzheimer's disease and Down's syndrome

1988 • 30 citations

Spermine modulation of the glutamate_{<scp>nmda</scp>} receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex

2002 • 29 citations

[Morphological changes in the human cerebral cortex in dementia].

1991 • 28 citations

Preservation of Redox, Polyamine, and Glycine Domains of the N‐Methyl‐D‐Aspartate in Alzheimer's Disease

1994 • 20 citations

Neurotoxic and neuroprotective effects of glutamate are enhanced by introduction of amyloid precursor protein cDNA

2001 • 17 citations

Abnormalities in Non-Cholinergic Neurotransmitter Systems in Alzheimer’s Disease

1994 • 16 citations

Cloning and sequence analysis of additional splice variants encoding human receptor (hNR1) subunits

1994 • 14 citations

S-adenosylmethionine decarboxylase in human brain. Regional distribution and influence of aging

1993 • 13 citations

Quantitation of alternatively spliced NMDA receptor NR1 isoform mRNA transcripts in human brain by competitive RT-PCR

2003 • 11 citations

The search for better noncholinergic treatment options for Alzheimer's disease.

2003 • 10 citations

Quantitation of NMDA receptor NR2 mRNA transcripts in human brain by competitive RT-PCR

2003 • 10 citations

Activators and Inhibitors of the Ion Channel of the NMDA Receptor

2001 • 8 citations

Changes in Memory Processes of Dementia Patients

1990 • 2 citations