A Regulatory Domain (R1–R2) in the Amino Terminus of theN-Methyl-d-Aspartate Receptor: Effects of Spermine, Protons, and Ifenprodil, and Structural Similarity to Bacterial Leucine/Isoleucine/Valine Binding Protein

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.

1993 • 978 citations

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

1993 • 828 citations

Structure of a glutamate-receptor ligand-binding core in complex with kainate

1998 • 672 citations

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

1990 • 553 citations

Interactions of polyamines with ion channels

1997 • 493 citations

Modulation of the N-methyl-D-aspartate channel by extracellular H+.

1990 • 458 citations

Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro

1993 • 447 citations

Control of Proton Sensitivity of the NMDA Receptor by RNA Splicing and Polyamines

1995 • 395 citations

Mutational analysis of the glycine-binding site of the NMDA receptor: Structural similarity with bacterial amino acid-binding proteins

1994 • 381 citations

Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C.

1993 • 347 citations

Control of Voltage-Independent Zinc Inhibition of NMDA Receptors by the NR1 Subunit

1998 • 263 citations

Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor

1994 • 251 citations

A novel mechanism of activity‐dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.

1996 • 230 citations

Periplasmic binding protein structure and function

1989 • 229 citations

Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits.

1994 • 219 citations

Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition

1998 • 218 citations

Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.

1989 • 215 citations

Multiple effects of spermine on N‐methyl‐D‐aspartic acid receptor responses of rat cultured hippocampal neurones.

1993 • 199 citations

Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.

1990 • 154 citations

Polyamines potentiate responses of N-methyl-D-aspartate receptors expressed in xenopus oocytes.

1990 • 142 citations

Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site.

1995 • 137 citations

Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism.

1991 • 127 citations

Block and Modulation ofN-Methyl-d-Aspartate Receptors by Polyamines and Protons: Role of Amino Acid Residues in the Transmembrane and Pore-Forming Regions of NR1 and NR2 Subunits

1997 • 103 citations

Mutagenesis rescues spermine and Zn2+ potentiation of recombinant NMDA receptors

1994 • 101 citations

Three-dimensional models of non-NMDA glutamate receptors

1996 • 101 citations

Crystal Structure of PotD, the Primary Receptor of the Polyamine Transport System in Escherichia coli

1996 • 88 citations

Spermidine-preferential Uptake System in Escherichia coli

1996 • 86 citations

An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons.

1996 • 83 citations

An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones

1998 • 80 citations

Mechanisms influencing stimulatory effects of spermine at recombinant N-methyl-D-aspartate receptors.

1994 • 74 citations

An acidic amino acid in the N-methyl-D-aspartate receptor that is important for spermine stimulation.

1995 • 69 citations

The selectivity filter of the N-methyl-D-aspartate receptor: a tryptophan residue controls block and permeation of Mg2+.

1998 • 68 citations

The NR2B-specific Interactions of Polyamines and Protons with theN-Methyl-d-aspartate Receptor

1997 • 62 citations

N¹-Dansyl-Spermine and N¹-(n-Octanesulfonyl)-Spermine, Novel Glutamate Receptor Antagonists: Block and Permeation ofN-Methyl-d-Aspartate Receptors

1997 • 62 citations

Rapid high-efficiency site-directed mutagenesis by the phosphorothioate approach.

1992 • 57 citations

Influence of extracellular pH on inhibition by ifenprodil at N-methyl-d-aspartate receptors in Xenopus oocytes

1997 • 56 citations

Structure−Activity Relationships for a Series of Bis(phenylalkyl)amines: Potent Subtype-Selective Inhibitors of N-Methyl-<scp>d</scp>-aspartate Receptors

1998 • 52 citations

Xenopus Oocytes express a unitary glutamate receptor endogenously

1997 • 43 citations

Assessment of pseudo-energy potentials by the best-five test: a new use of the three-dimensional profiles of proteins

1997 • 33 citations

Three dimensional models of glutamate receptors

1998 • 4 citations