Animal and drug modelling for Alzheimer synaptic pathology

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Human Memory and the Cholinergic System

1974 • 1,378 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

1986 • 1,148 citations

Excitatory amino acid receptors and synaptic plasticity

1990 • 872 citations

The Cholinergic Synapse and the Site of Memory

1972 • 741 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

The Natural History of Mental Disorder in Old Age

1955 • 713 citations

The Prevalence of Dementia in Europe: A Collaborative Study of 1980–1990 Findings

1991 • 674 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex

1991 • 599 citations

Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence

1991 • 598 citations

Serotonin receptors in the human brain—III. Autoradiographic mapping of serotonin-1 receptors

1987 • 569 citations

Dementia of frontal lobe type.

1988 • 550 citations

Prevalence and Malignancy of Alzheimer Disease

1976 • 515 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

G Proteins in Signal Transduction

1990 • 479 citations

The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions

1991 • 467 citations

Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin

1987 • 463 citations

Evidence for a cholinergic projection to neocortex from neurons in basal forebrain.

1979 • 459 citations

Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's Disease

1983 • 440 citations

Presynaptic Cholinergic Dysfunction in Patients with Dementia

1983 • 422 citations

Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease

1991 • 421 citations

Frequency and distribution of Alzheimer's disease in Europe: A collaborative study of 1980–1990 prevalence findings

1991 • 383 citations

Psychiatric Phenomena in Alzheimer's Disease. IV: Disorders of Behaviour

1990 • 382 citations

Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis

1987 • 376 citations

The Clinical Efficacy of Citalopram in Treatment of Emotional Disturbances in Dementia Disorders a Nordic Multicentre Study

1990 • 375 citations

Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

1981 • 362 citations

Neurochemical Studies of Early-Onset Alzheimer's Disease

1985 • 356 citations

Convergence and divergence of neurotransmitter action in human cerebral cortex.

1989 • 349 citations

Synaptic targets of HRP-filled layer III pyramidal cells in the cat striate cortex

1986 • 324 citations

Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts

1985 • 313 citations

Intravenous nicotine in Alzheimer's disease: a pilot study

1988 • 312 citations

Correlation between Scores for Dementia and Counts of ‘Senile Plaques’ in Cerebral Grey Matter of Elderly Subjects

1966 • 293 citations

Place navigation in rats is impaired by lesions of medial septum and diagonal band but not nucleus basalis magnocellularis

1988 • 289 citations

Serotonin, memory, and the aging brain

1991 • 287 citations

Alzheimer's disease: a correlative study.

1986 • 269 citations

D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats

1989 • 253 citations

Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study

1978 • 252 citations

A STUDY OF THALAMO-STRIATE RELATIONS IN THE MONKEY

1956 • 240 citations

Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia.

1987 • 238 citations

Psychiatric Phenomena in Alzheimer's Disease. III: Disorders of Mood

1990 • 234 citations

The effects of physostigmine and scopolamine on recognition memory in monkeys

1986 • 224 citations

Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zone

1987 • 221 citations

The Molecular basis of neuropathology

1981 • 217 citations

The role of cholinergic projections from the nucleus basalis in memory

1991 • 213 citations

Presynaptic Serotonergic Dysfunction in Patients with Alzheimer's Disease

1987 • 213 citations

The Cholinergic Hypothesis of Memory: A Review of Animal Experiments

1988 • 210 citations

Biological Aspects of Alzheimer's Disease

1984 • 203 citations

Evidence of Glutamatergic Denervation and Possible Abnormal Metabolism in Alzheimer's Disease

1988 • 200 citations

Two distinct effects of 5-hydroxytryptamine on single cortical neurons

1987 • 197 citations

Alzheimer's disease: Changes in hippocampal N-methyl-d-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors—an autoradiographic study

1990 • 195 citations

Possible neurotransmitter basis of behavioral changes in alzheimer's disease

1988 • 190 citations

Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease

1987 • 185 citations

Learning and memory

1977 • 183 citations

Suicide Transport: Destruction of Neurons by Retrograde Transport of Ricin, Abrin, and Modeccin

1982 • 178 citations

Cholinergic Basis for Alzheimer Therapy

1991 • 177 citations

Mitochondrial function in brain tissue in primary degenerative dementia

1987 • 177 citations

Nerve growth factor potentiates the neurotoxicity of beta amyloid.

1990 • 171 citations

Tacrine: A pharmacological review

1991 • 168 citations

Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2 -activated interneuron

1990 • 167 citations

Cajal on the Cerebral Cortex: An Annotated Translation of the Complete Writings

1989 • 166 citations

Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer's disease

1986 • 155 citations

Clinical history, brain metabolism, and neuropsychological function in Alzheimer's disease

1985 • 150 citations

Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life.

1989 • 148 citations

A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease

1988 • 146 citations

Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus

1987 • 144 citations

Selective localization of striatal D1 receptors to striatonigral neurons

1990 • 143 citations

Postsynaptic 5-HT1 receptors and offensive aggression in rats: A combined behavioural and autoradiographic study with eltoprazine

1991 • 138 citations

Topographical distribution of neurochemical changes in Alzheimer's disease

1988 • 137 citations

Cognitive deficits in olivopontocerebellar atrophy: Implications for the cholinergic hypothesis of Alzheimer's dementia

1988 • 137 citations

CHEMICAL PATHOLOGY OF THE ORGANIC DEMENTIAS

1977 • 134 citations

AN ELECTRON MICROSCOPIC STUDY OF THE TYPES AND PROPORTIONS OF NEURONS IN THE CORTEX OF THE MOTOR AND VISUAL AREAS OF THE CAT AND RAT

1980 • 134 citations

Catecholaminergic neurones assessed ante-mortem in Alzheimer's disease

1987 • 131 citations

An Immunotoxin Composed of Monoclonal Anti-Thy 1.1 Antibody and a Ribosome-Inactivating Protein From <italic>Saponaria officinalis:</italic> Potent Antitumor Effects In Vitro and In Vivo

1985 • 130 citations

GAMMA-AMINOBUTYRIC ACID CONCENTRATION IN BRAIN TISSUE AT TWO STAGES OF ALZHEIMER'S DISEASE

1988 • 130 citations

5.HT1 receptors in the vertebrate brain

1989 • 126 citations

Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease

1990 • 121 citations

Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease

1986 • 118 citations

Is ethylcholine mustard aziridinium ion a specific cholinergic neurotoxin?

1987 • 116 citations

Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus

1991 • 113 citations

Etiology of dementia of Alzheimer's type

1989 • 111 citations

Differential pharmacology and function of two 5-HT1 receptors modulating transmitter release in rat cerebellum.

1986 • 110 citations

Binding of the Novel Serotonin Agonist 8‐Hydroxy‐2‐(Di‐n‐Propylamino) Tetralin in Normal and Alzheimer Brain

1986 • 105 citations

RETRACTED ARTICLE: Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein

1991 • 104 citations

Alzheimer's disease

1987 • 103 citations

Learning and memory

1991 • 101 citations

Neuropsychiatric disorders and the multiple human brain serotonin receptor subtypes and subsystems.

1990 • 100 citations

Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.

1991 • 100 citations

Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias.

1990 • 100 citations

Multiple-Dose Arecoline Infusions in Alzheimer's Disease

1988 • 99 citations

Selective vulnerability of neurones in organic dementia

1977 • 99 citations

MENTAL ILLNESS AND THE AGEING BRAIN

1963 • 98 citations

A critical evaluation of monkey models of amnesia and dementia

1991 • 98 citations

Induction of depression with oxotremorine in patients with Alzheimer's disease

1987 • 94 citations

Cortical GABA _B and GABA _A receptors in Alzheimer's disease

1987 • 94 citations

Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease

1990 • 94 citations

Hyperresponsivity to the Serotonin Agonist m-Chlorophenylpiperazine in Alzheimer's Disease

1989 • 91 citations

Biology of Serotonergic Transmission

1983 • 91 citations

A quantitative study of the neurofibrillary tangles and the choline acetyltransferase activity in the cerebral cortex and the amygdala in Alzheimer's disease.

1990 • 90 citations

Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents

1989 • 90 citations

Lack of Efficacy of Hydergine in Patients with Alzheimer's Disease

1990 • 90 citations

Degeneration of cholinergic neurons in the basal nucleus following kainic or N-methyl-D-aspartic acid application to the cerebral cortex in the rat

1985 • 90 citations

Intravenous physostigmine treatment of Alzheimer's disease evaluated by psychometric testing, regional cerebral blood flow (rCBF) measurement, and EEG

1987 • 88 citations

A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease

1991 • 88 citations

RS 86 in the treatment of alzheimer's disease: Cognitive and biological effects

1987 • 87 citations

The nature of wandering in dementia: A community‐based study

1990 • 87 citations

The connexions of the midline and intralaminar nuclei of the thalamus of the rat.

1954 • 83 citations

No response to high‐dose muscarinic agonist therapy in Alzheimer's disease

1988 • 80 citations

Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type.

1990 • 78 citations

Properties of volkensin, a toxic lectin from Adenia volkensii.

1985 • 78 citations

Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease

1983 • 77 citations

Serotonin-glutamate interaction in rat cerebellum: involvement of 5-HT1 and 5-HT2 receptors

1988 • 77 citations

M-current in human neocortical neurones

1986 • 75 citations

Glycine prodrug facilitates memory retrieval in humans

1991 • 75 citations

Monoamine metabolite concentrations in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.

1984 • 72 citations

Robustness of G Proteins in Alzheimer's Disease: An Immunoblot Study

1991 • 71 citations

Abnormal Temporal Lobe Response in Alzheimer's Disease during Cognitive Processing as Measured by ¹¹C-2-Deoxy-D-Glucose and PET

1987 • 63 citations

Serotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms

1992 • 63 citations

d-Cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-d-aspartate receptor-ionophore complex in Alzheimer brain

1991 • 63 citations

Loss of glycine-dependent radioligand binding to the receptor complex in patients with Alzheimer's disease

1989 • 63 citations

In situ hybridization histochemistry and the study of gene expression in the human brain

1990 • 62 citations

Inhibition of spontaneous and evoked unit activity in the rat medial prefrontal corte by mesencephalic raphe nuclei

1990 • 61 citations

Alzheimer's Disease

1969 • 61 citations

Modeccin and volkensin but not abrin are effective suicide transport agents in rat CNS

1988 • 61 citations

Somatostatin content and release measured in cerebral biopsies from demented patients

1987 • 60 citations

Increased density of excitatory amino acid transport sites in the hippocampal formation following an entorhinal lesion

1991 • 58 citations

Treatment of Alzheimer's Disease

1990 • 57 citations

Cellular localization of serotonin 1A, 1B and uptake sites in cingulate cortex of the rat.

1990 • 56 citations

A double‐blind comparison of alaproclate and placebo in the treatment of patients with senile dementia

1985 • 54 citations

Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats

1980 • 53 citations

Na⁺‐Dependent “Binding” of D‐Aspartate in Brain Membranes Is Largely Due to Uptake into Membrane‐Bounded Saccules

1986 • 52 citations

Activation of presynaptic 5-hydroxytryptamine1-like receptors on glutamatergic terminals inhibits N-methyl-D-aspartate-induced cyclic GMP production in rat cerebellar slices.

1991 • 52 citations

Disruption of memory produced by stimulation of the dorsal raphe nucleus: mediation by serotonin

1978 • 51 citations

The evoked release of endogenous amino acids from tissue prisms of human neocortex

1983 • 51 citations

Alzheimer's disease: is there a problem beyond recognition?

1990 • 50 citations

Glutamic Acid as a Putative Transmitter of the Interhemispheric Corticocortical Connections in the Rat

1986 • 48 citations

Characterization of a novel and potent 5-hydroxytryptamine1A receptor antagonist

1991 • 46 citations

Somatostatin-like immunoreactivity in lumbar cerebrospinal fluid from neurohistologically examined demented patients

1984 • 44 citations

GABA-Agonist Therapy for Alzheimerʼs Disease

1986 • 44 citations

Galanin‐Like Immunoreactivity Is Unchanged in Alzheimer's Disease and Parkinson's Disease Dementia Cerebral Cortex

1988 • 44 citations

Primary degeneration of motor neurons by toxic lectins conveyed from the peripheral nerve

1985 • 43 citations

The association of [3H]d-aspartate binding and high-affinity glutamate uptake in the human brain

1986 • 43 citations

Separation of the associative and non-associative effects of brain serotonin released by p-chloroamphetamine: Dissociable serotoninergic involvement in avoidance learning, pain and motor function

1985 • 42 citations

Ricin transport distinguishes between central and peripheral neurons

1983 • 41 citations

Mental Illness and The Ageing Brain

1963 • 38 citations

Neuronotoxic effects of monoclonal anti-Thy 1 antibody (OX7) coupled to the ribosome inactivating protein, saporin, as studied by suicide transport experiments in the rat

1989 • 38 citations

Age dependent effects of 5-hydroxytryptamine upon memory consolidation and cerebral protein synthesis

1973 • 38 citations

Sodium-dependentd-aspartate ‘binding’ is not a measure of presynaptic neuronal uptake sites in an autoradiographic assay

1990 • 37 citations

Cholinesterase and its molecular forms in pathological states

1988 • 36 citations

A new method for quenching correction leads to revisions of data in receptor autoradiography

1990 • 35 citations

NEURONOTOXICITY OF AXONALLY TRANSPORTED TOXIC LECTINS, ABRIN, MODECCIN AND VOLKENSIN IN RAT PERIPHERAL NERVOUS SYSTEM

1987 • 35 citations

Characterisation of the Glycine Modulatory Site of the N‐Methyl‐<scp>d</scp>‐Aspartate Receptor‐Ionophore Complex in Human Brain

1991 • 34 citations

A review of neuropathological and neurochemical correlates of Alzheimer's disease.

1985 • 29 citations

Destruction of a sub-population of cortical neurones by suicide transport of volkensin, a lectin from Adenia volkensii

1991 • 29 citations

Antemortem measurements of neurotransmission: possible implications for pharmacotherapy of Alzheimer's disease and depression.

1993 • 27 citations

Effect of Central Cholinergic Stimulation on Regional Cerebral Blood Flow in Alzheimer's Disease

1991 • 26 citations

Somatostatin replacement therapy for alzheimer dementia

1991 • 25 citations

Electrophysiological effects of tianeptine on rat locus coeruleus, raphe dorsalis, and hippocampus activity.

1988 • 25 citations

Studies in presenile dementia.

1961 • 23 citations

Spermidine enhancement of [3H]MK-801 binding to the NMDA receptor complex in human cortical membranes

1990 • 22 citations

Analgesia induced by brief or more prolonged stress differs in its dependency on naloxone, 5-hydroxytryptamine and previous testing of analgesia

1984 • 22 citations

Release of endogenous aspartate from rat cerebellum slices and synaptosomes: inhibition mediated by a 5-HT2 receptor and by a 5-HT1 receptor of a possibly novel subtype

1991 • 19 citations

The design of full agonists for the cortical muscarinic receptor.

1989 • 16 citations

Neurobiology of the NMDA receptor: From chemistry to the clinic

1992 • 16 citations

Anatomical and neurochemical evidence for suicide transport of a toxic lectin, volkensin, injected in the rat dorsal hippocampus

1990 • 16 citations

Therapy for Alzheimerʼs Disease: Choosing a Target

1991 • 13 citations

Topography of the glycine site of the NMDA receptor

1990 • 12 citations

New Intrathecal Drugs in Alzheimer's Disease and Psychometric Testing

1988 • 12 citations

Alzheimer's Disease: towards an understanding of the aetiology and pathogenesis

1990 • 10 citations

High affinity serotonin binding sites in human brain: a comparison of cerebral cortex and basal ganglia

1989 • 10 citations

Neurochemical studies of early-onset Alzheimerʼs disease

1987 • 10 citations

Toward a Third Generation of Cholinesterase Inhibitors

1991 • 7 citations

A Topological Model of the NMDA-Glycine Receptor Model

1990 • 7 citations

Effects of tetrahydroaminoacridine (THA) on functional recovery after sequential lesion of the entorhinal cortex

1991 • 6 citations

Molecular Neuropathology

1996 • 5 citations

10. THA, A putative drug in the treatment of Alzheimer's disease?

2009 • 3 citations

Neurotransmitter uptake and binding in ischaemia and organic dementia.

1980 • 2 citations