7 EGF Receptor Signaling in Drosophila Oogenesis

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The development of Drosophila melanogaster

1994 • 3,057 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1988 • 1,077 citations

Reiterative Use of the EGF Receptor Triggers Differentiation of All Cell Types in the Drosophila Eye

1996 • 879 citations

Developmental genetics of oogenesis

1993 • 858 citations

The Ets family of transcription factors

1993 • 848 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

Transforming growth factor α

1988 • 707 citations

Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector.

1989 • 688 citations

P-element-mediated enhancer detection: a versatile method to study development in Drosophila.

1989 • 679 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A

1988 • 625 citations

Establishment of dorsal-ventral polarity in the drosophila embryo: The induction of polarity by the Toll gene product

1985 • 607 citations

A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases

1988 • 602 citations

The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein.

1993 • 567 citations

The intracellular localization of messenger RNAs

1995 • 534 citations

D‐E‐A‐D protein family of putative RNA helicases

1992 • 516 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

Polarization of both major body axes in Drosophila by gurken-torpedo signalling

1995 • 485 citations

cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila

1995 • 480 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation

1994 • 451 citations

Translational regulation of oskar mRNA by Bruno, an ovarian RNA-binding protein, is essential

1995 • 451 citations

The drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGFα-like protein

1993 • 443 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila.

1989 • 401 citations

Reorganization of the cytoskeleton during Drosophila oogenesis: implications for axis specification and intercellular transport

1992 • 399 citations

Translational regulation in development

1995 • 394 citations

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.

1990 • 389 citations

Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster

1987 • 373 citations

Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila

1991 • 372 citations

chickadee encodes a profilin required for intercellular cytoplasm transport during Drosophila oogenesis

1992 • 370 citations

Requirement of the DEAD-Box Protein Ded1p for Messenger RNA Translation

1997 • 363 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells

1993 • 330 citations

Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities

1994 • 328 citations

The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo

1994 • 321 citations

The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway.

1993 • 320 citations

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

1995 • 312 citations

Translational regulation of nanos by RNA localization

1994 • 307 citations

Autosomal P[ovo D1 ] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras

1993 • 302 citations

Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo

1997 • 294 citations

vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst development

1998 • 292 citations

The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.

1992 • 278 citations

The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog

1989 • 268 citations

The polarity of the dorsoventral axis in the drosophila embryo is defined by an extracellular signal

1991 • 260 citations

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos

1995 • 251 citations

A thousand and one roles for the Drosophila EGF receptor

1997 • 250 citations

cappuccino and spire: two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophila embryo.

1989 • 246 citations

Translational control of oskar generates Short OSK, the isoform that induces pole plasm assembly

1995 • 243 citations

The argos gene encodes a diffusible factor that regulates cell fate decisions in the drosophila eye

1992 • 238 citations

argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop

1996 • 235 citations

The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development

1989 • 235 citations

The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm

1996 • 232 citations

Activators and effectors of ras p21 proteins

1994 • 228 citations

The Ras signaling pathway in Drosophila

1995 • 226 citations

Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle

1997 • 221 citations

Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins.

1996 • 218 citations

The TGF-β signaling pathway is essential for Drosophila oogenesis

1996 • 218 citations

Translational repressorbruno plays multiple roles in development and is widely conserved

1997 • 213 citations

okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis

1998 • 211 citations

Localization of oskar RNA regulates oskar translation and requires Oskar protein

1995 • 208 citations

The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae

1997 • 205 citations

The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains

1985 • 202 citations

Intercellular signaling and the polarization of body axes during Drosophila oogenesis.

1996 • 202 citations

The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila

1997 • 194 citations

Oocyte polarity depends on regulation of gurken by Vasa

1998 • 188 citations

orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis.

1994 • 187 citations

Patterning of the follicle cell epithelium along the anterior-posterior axis during Drosophila oogenesis

1998 • 183 citations

Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis.

1994 • 182 citations

Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesis

1997 • 174 citations

EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm

1996 • 170 citations

Triggering signaling cascades by receptor tyrosine kinases

1992 • 168 citations

Cell lineage, stem cells and cell determination

1980 • 167 citations

The Drosophila orb gene is predicted to encode sex-specific germline RNA-binding proteins and has localized transcripts in ovaries and early embryos

1992 • 165 citations

The Drosophila TGF-α-like protein Gurken: expression and cellular localization during Drosophila oogenesis

1996 • 165 citations

Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene.

1989 • 163 citations

A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo

1994 • 161 citations

Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus.

1995 • 159 citations

Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA-dependent ATPases.

1995 • 156 citations

Oocyte determination and the origin of polarity in Drosophila: the role of the spindle genes

1997 • 154 citations

Premature Microtubule-Dependent Cytoplasmic Streaming in cappuccino and spire Mutant Oocytes

1994 • 153 citations

Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis

1993 • 149 citations

Profilin is required for posterior patterning of the Drosophila oocyte

1996 • 146 citations

Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene.

1993 • 139 citations

The dorsal protein is distributed in a gradient in early drosophila embryos

1988 • 137 citations

There Must Be 50 Ways to Rule the Signal: The Case of the Drosophila EGF Receptor

1997 • 134 citations

The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis

1996 • 131 citations

Cell-cell interactions in early development

1994 • 128 citations

The Drosophila TGFα homolog Spitz acts in photoreceptor recruitment in the developing retina

1997 • 124 citations

RNA localization along the anteroposterior axis of the Drosophila oocyte requires PKA-mediated signal transduction to direct normal microtubule organization.

1994 • 124 citations

fs(1)K10, a germline-dependent female sterile mutation causing abnormal chorion morphology inDrosophila melanogaster

1978 • 121 citations

Establishment of ventral cell fates in the Drosophila embryonic ectoderm requires DER, the EGF receptor homolog.

1993 • 117 citations

Dorsoventral axis formation in Drosophila depends on the correct dosage of the gene gurken

1994 • 115 citations

Actin cytoskeleton: Are FH proteins local organizers?

1997 • 114 citations

The Nonreceptor Protein Tyrosine Phosphatase Corkscrew Functions in Multiple Receptor Tyrosine Kinase Pathways inDrosophila

1996 • 114 citations

The relationship between ovarian and embryonic dorsoventral patterning in Drosophila

1994 • 113 citations

Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis

1998 • 112 citations

TheDrosophila kekkonGenes: Novel Members of both the Leucine-Rich Repeat and Immunoglobulin Superfamilies Expressed in the CNS

1996 • 109 citations

Alternative 5′ exons and tissue-specific expression of the Drosophila EGF receptor homolog transcripts

1986 • 106 citations

Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila

1994 • 102 citations

The neurogenic locus brainiac cooperates with the Drosophila EGF receptor to establish the ovarian follicle and to determine its dorsal-ventral polarity

1992 • 99 citations

Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes

1997 • 97 citations

Pointed, an ETS domain transcription factor, negatively regulates the EGF receptor pathway in Drosophila oogenesis

1996 • 95 citations

Identifying targets of the rough homeobox gene of Drosophila: evidence that rhomboid functions in eye development

1992 • 90 citations

Signaling Pathways that Establish the Dorsal-Ventral Pattern of the Drosophila Embryo

1995 • 86 citations

maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA

1997 • 84 citations

Translational regulation of maternal mRNAs

1996 • 80 citations

Localized Requirements for windbeutel and pipe Reveal a Dorsoventral Prepattern within the Follicular Epithelium of the Drosophila Ovary

1998 • 73 citations

shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-β-responsive gene

1995 • 72 citations

Dissection of the faint little ball (fib) phenotype: determination of the development of the Drosophila central nervous system by early interactions in the ectoderm

1992 • 71 citations

brainiacEncodes a Novel, Putative Secreted Protein That Cooperates with Grk TGFα in the Genesis of the Follicular Epithelium

1996 • 67 citations

A Drosophila genomic sequence with homology to human epidermal growth factor receptor

1985 • 66 citations

Star Is Required for Neuronal Differentiation in the Drosophila Retina and Displays Dosage-Sensitive Interactions with Ras1

1993 • 63 citations

A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases.

1994 • 60 citations

Essential role for a heterogeneous nuclear ribonucleoprotein (hnRNP) in oogenesis: hrp40 is absent from the germ line in the dorsoventral mutant squid.

1994 • 57 citations

Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction.

1994 • 56 citations

Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos

1997 • 56 citations

The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis

1997 • 51 citations

Expression of Drosophila epidermal growth factor receptor homologue in mitotic cell populations

1987 • 49 citations

Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation

1998 • 47 citations

The transcriptional factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis.

1996 • 47 citations

Cell-cell signaling, microtubules, and the loss of symmetry in the drosophila oocyte

1995 • 46 citations

Role of the oocyte nucleus in determination of the dorsoventral polarity of Drosophila as revealed by molecular analysis of the K10 gene

1988 • 44 citations

Expeditions to the pole: RNA localization in and

1997 • 41 citations

Differential Activity of Ras1 during Patterning of the Drosophila Dorsoventral Axis

1996 • 41 citations

The role of fs(1)K10 in the localization of the mRNA of the TGFα homolog gurken within the Drosophila oocyte

1995 • 32 citations

Gratuitous mRNA localization in the Drosophila oocyte

1995 • 25 citations

Multiple Ras Signals Pattern theDrosophilaOvarian Follicle Cells

1997 • 23 citations

The egghead gene product influences oocyte differentiation by follicle cell–germ cell interactions in Drosophila melanogaster

1998 • 20 citations

Ets oncogene-related gene Elg functions in Drosophila oogenesis.

1993 • 20 citations

Requirement of the ETS domain transcription factor D-ELG for egg chamber patterning and development during Drosophila oogenesis.

1995 • 9 citations

hold up Is Required for Establishment of Oocyte Positioning, Follicle Cell Fate and Egg Polarity and Cooperates with Egfr during Drosophila Oogenesis

1998 • 9 citations