Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice

Sequences of proteins of immunological interest

1984 • 3,427 citations

High gradient magnetic cell separation with MACS

1990 • 1,648 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

1992 • 456 citations

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

1995 • 436 citations

Towards a comprehensive view of immunoglobulin class switching

1993 • 373 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

Antibody engineering for the analysis of affinity maturation of an anti-hapten response.

1988 • 275 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Peanut lectin binding properties of germinal centers of mouse lymphoid tissue

1980 • 259 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions.

1993 • 250 citations

The generation of memory cells. I. The role of C3 in the generation of B memory cells.

1977 • 235 citations

Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP.

1986 • 227 citations

Targeting of non-lg sequences in place of the V segment by somatic hyper mutation

1995 • 223 citations

Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.

1993 • 218 citations

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations

1989 • 215 citations

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.

1990 • 200 citations

Structure of primary anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice

1985 • 184 citations

The Development of B Cells and the B‐Cell Repertoire in the Microenvironment of the Germinal Center

1992 • 148 citations

Splenic dependence of the antibody response to thymus‐independent (TI‐2) antigens

1985 • 145 citations

Differences in the recruitment of virgin B cells into antibody responses to thymus‐dependent and thymus‐independent type‐2 antigens

1986 • 99 citations

Natural occurrence and origin of somatically mutated memory B cells in mice.

1992 • 71 citations

Polyester Wax Embedding and Sectioning Technique for Immunohistochemistry

1984 • 71 citations

Development of intestinal intraepithelial T lymphocytes is independent of Peyer's patches and lymph nodes in aly mutant mice.

1994 • 65 citations

The Path of Memory B‐Cell Development

1992 • 42 citations

Regulation of class switch recombination of the immunoglobulin heavy chain genes

1995 • 32 citations

De novo Germinal Center Formation

1992 • 30 citations