Towards a comprehensive view of immunoglobulin class switching

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

1986 • 777 citations

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

1988 • 731 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

1982 • 445 citations

Subclass Restriction of Murine Anti-Carbohydrate Antibodies

1978 • 428 citations

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production.

1989 • 394 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma.

1988 • 315 citations

Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production.

1983 • 288 citations

Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways.

1991 • 270 citations

Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens.

1992 • 258 citations

Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.

1990 • 240 citations

Immunoglobulin Class Switching: Molecular and Cellular Analysis

1990 • 224 citations

Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial stimuli

1991 • 215 citations

Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells

1988 • 211 citations

T cell regulation of IgG subclass antibody production in response to T-independent antigens.

1981 • 181 citations

Mouse IgG3 antibodies are highly protective against infection with Streptococcus pneumoniae

1981 • 170 citations

Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation.

1988 • 156 citations

Hydrocortisone and IL-4 induce IgE isotype switching in human B cells.

1991 • 149 citations

The Transforming Growth Factor‐Betas: A New Family of Immunoregulatory Molecules

1990 • 103 citations

In vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated autoimmune syndrome.

1990 • 93 citations

Intermolecular cooperativity: a clue to why mice have IgG3?

1992 • 89 citations

Dextran-conjugated anti-Ig antibodies as a model for T cell-independent type 2 antigen-mediated stimulation of Ig secretion in vitro. I. Lymphokine dependence.

1991 • 85 citations

Induction of human IgE synthesis by CD4+ T cell clones. Requirement for interleukin 4 and low molecular weight B cell growth factor.

1989 • 80 citations

IgE class switching is critically dependent upon the nature of the B cell activator, in addition to the presence of IL-4.

1991 • 68 citations

B cell response to T helper cell subsets. II. Both the stage of T cell differentiation and the cytokines secreted determine the extent and nature of helper activity.

1991 • 66 citations

T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells.

1992 • 44 citations

Recombinant interleukin 2‐activated natural killer cells regulate IgG_2a production

1990 • 24 citations

Helper activity by human large granular lymphocytes inin vitro immunoglobulin synthesis

1987 • 17 citations