Early Antigen-Specific Response by Naive CD8 T Cells Is Not Altered with Aging

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

The Aging Immune System: Primer and Prospectus

1996 • 1,166 citations

T CELL MEMORY

1998 • 863 citations

Rapid Effector Function in CD8+ Memory T Cells

1997 • 652 citations

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

1984 • 528 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Differentiation of Naive CTL to Effector and Memory CTL: Correlation of Effector Function with Phenotype and Cell Division

1998 • 379 citations

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein

1992 • 286 citations

Pgp‐1^hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A

1989 • 279 citations

Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice.

1990 • 264 citations

Antigen-independent changes in naive CD4 T cells with aging.

1996 • 240 citations

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations

1989 • 215 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

1984 • 183 citations

Discussion

1997 • 175 citations

The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression.

1993 • 168 citations

Kinetics of the response of naive and memory CD8 T cells to antigen: similarities and differences

1999 • 163 citations

Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis.

1982 • 159 citations

Empty and peptide-containing conformers of class I major histocompatibility complex molecules expressed in Drosophila melanogaster cells.

1992 • 143 citations

Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cell.

1984 • 140 citations

T cells and aging (update February 1999)

1999 • 135 citations

Polymorphism of age‐related changes in interleukin (IL) production: differential changes of T helper subpopulations, synthesizing IL 2, IL3 and IL4

1990 • 130 citations

A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone.

1993 • 129 citations

From naive to effector ‐ alterations with aging

1997 • 118 citations

TransfectedDrosophilacells as a probe for defining the minimal requirements for stimulating unprimed CD8⁺T cells

1996 • 117 citations

Aged T cells are hyporesponsive to costimulation mediated by CD28.

1994 • 116 citations

Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules.

1992 • 111 citations

Qualitative Differences Between Naive and Memory T Cells Make a Major Contribution to the More Rapid and Efficient Memory CD8+ T Cell Response

1998 • 103 citations

Cytokine production by T lymphocytes from young and aged mice.

1996 • 99 citations

Memory T lymphocyte hyporesponsiveness to non‐cognate stimuli: a key factor in age‐related immunodeficiency

1992 • 95 citations

Effect of food restriction on life span and immune functions in long-lived Fischer-344 x Brown Norway F1 rats.

1997 • 88 citations

Influence of antigen dose and costimulation on the primary response of CD8+ T cells in vitro.

1996 • 87 citations

Age‐associated changes in mitogen‐induced protein phosphorylation in murine T lymphocytes

1992 • 82 citations

Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity. Implications for the age-related decline in CTL.

1994 • 79 citations

Cytokines and impaired CD8+ CTL activity among elderly persons and the enhancing effect of IL-121This paper was presented at the First International Conference on Immunology and Aging, June 13–19, 1996, Bethesda, MD, USA.1

1997 • 66 citations

Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets. Effect of age.

1993 • 63 citations

Influence of age on the signal transduction of T cells in mice

1993 • 60 citations

Limiting dilution analysis of alloreactive cytotoxic precursor cells in aging mice.

1983 • 59 citations

The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis

1984 • 58 citations

Cellular basis of decreased immune responses to pneumococcal vaccines in aged mice

1996 • 58 citations

Age-related changes in CD4 T cells of T cell receptor transgenic mice

1997 • 41 citations

Decline in the production of interleukin-3 with age in mice

1988 • 38 citations

The Age-Dependent Cytokine Production by Murine CD8+ T Cells as Determined by Four-Color Flow Cytometry Analysis

1999 • 28 citations

Probing the activation requirements for naive CD8⁺ T cells with Drosophila cell transfectants as antigen presenting cells

1998 • 28 citations

Dynamic phenotypic restructuring of the CD4 and CD8 T-cell subsets with age in healthy humans: a compartmental model analysis

1998 • 18 citations

Age-associated changes in lymphoid and antigen-presenting cell functions in mice immunized with Trypanosoma cruzi antigens

1996 • 17 citations

Amplification of cytokine-specific ELISAs increases the sensitivity of detection to 5–20 picograms per milliliter

1999 • 17 citations