Cutting Edge: A Crucial Role for B7-CD28 in Transmitting T Help from APC to CTL

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

The JAM test A simple assay for DNA fragmentation and cell death

1991 • 632 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

1996 • 411 citations

T cell co-stimulatory molecules other than CD28

1999 • 349 citations

The role of B7 co‐stimulation in activation and differentiation ofCD4⁺and CD8⁺T cells

1998 • 306 citations

A fail-safe mechanism for maintaining self-tolerance.

1992 • 213 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

CTLA-4 and T cell activation

1999 • 209 citations

Role of CD28-B7 Interactions in Generation and Maintenance of CD8 T Cell Memory

2001 • 192 citations

CD28 as a Molecular Amplifier Extending TCR Ligation and Signaling Capabilities

2001 • 183 citations

Antigen presentation to cytotoxic T lymphocytes in vivo.

1995 • 168 citations

Bone Marrow–Derived Antigen-Presenting Cells Are Required for the Generation of Cytotoxic T Lymphocyte Responses to Viruses and Use Transporter Associated with Antigen Presentation (Tap)-Dependent and -Independent Pathways of Antigen Presentation

2000 • 138 citations

CD28-independent Costimulation of T Cells in Alloimmune Responses

2001 • 117 citations

Cytotoxic T lymphocyte activation by cross-priming

1999 • 108 citations

Requirements for Bone Marrow–Derived Antigen-Presenting Cells in Priming Cytotoxic T Cell Responses to Intracellular Pathogens

2000 • 99 citations

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4

2001 • 86 citations

The Role of B7-1 and B7-2 Costimulation for the Generation of CTL Responses In Vivo

1998 • 73 citations

Cross-presentation: inducing CD8 T cell immunity and tolerance

2000 • 48 citations

Cross-priming of CTL responses in vivo does not require antigenic peptides in the endoplasmic reticulum of immunizing cells.

1998 • 44 citations

Cutting Edge: Cross-Priming of CTL Responses In Vivo Does Not Require Antigenic Peptides in the Endoplasmic Reticulum of Immunizing Cells

1998 • 34 citations

From antigen presentation to T-cell activation

1998 • 13 citations