Heterogeneous effects of B7‐1 and B7‐2 in the induction of both protective and therapeutic anti‐tumor immunity against different mouse tumors

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

1995 • 489 citations

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

1994 • 482 citations

Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice

1993 • 369 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

Structure of the gene of tum− transplantation antigen P91A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cells

1989 • 296 citations

Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now?

1994 • 245 citations

Costimulation of T-cell growth

1992 • 225 citations

Major histocompatibility complex class II+B7-1+ tumor cells are potent vaccines for stimulating tumor rejection in tumor-bearing mice.

1995 • 190 citations

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.

1994 • 167 citations

Induction of antitumor immunity by recombinant vaccinia viruses expressing B7-1 or B7-2 costimulatory molecules.

1994 • 166 citations

Antitumor immunity elicited by tumor cells transfected with B7-2, a second ligand for CD28/CTLA-4 costimulatory molecules.

1995 • 133 citations

Role of B7-1 in mediating an immune response to myeloid leukemia cells

1995 • 122 citations

Co‐expression of B7‐1 and ICAM‐1 on tumors is required for rejection and the establishment of a memory response

1995 • 116 citations

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion

1995 • 74 citations

Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.

1994 • 70 citations

Draft proposals for interleukin nomenclature

1986 • 13 citations

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