Functional regions of the inhibitory subunit of retinal rod cGMP phosphodiesterase identified by site-specific mutagenesis and fluorescence spectroscopy

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Cyclic GMP-Activated Conductance of Retinal Photoreceptor Cells

1989 • 582 citations

Visual excitation and recovery

1991 • 530 citations

Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments.

1979 • 448 citations

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

1974 • 431 citations

[29] Synthesis and sequence-specific proteolysis of hybrid proteins produced in Escherichia coli

1987 • 392 citations

Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.

1987 • 383 citations

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

1982 • 336 citations

Molecular mechanism of visual transduction

1989 • 312 citations

Purification and properties of the light-activated cyclic nucleotide phosphodiesterase of rod outer segments

1975 • 271 citations

THE MOLECULAR MECHANISM OF VISUAL EXCITATION AND ITS RELATION TO THE STRUCTURE AND COMPOSITION OF THE ROD OUTER SEGMENT

1987 • 264 citations

cGMP phosphodiesterase of retinal rods is regulated by two inhibitory subunits.

1988 • 246 citations

Light response of vertebrate photoreceptors

1990 • 208 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 167 citations

Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its γ subunit and transducin

1986 • 151 citations

Subunit stoichiometry of retinal rod cGMP phosphodiesterase

1990 • 138 citations

Interactions between the subunits of transducin and cyclic GMP phosphodiesterase in Rana catesbiana rod photoreceptors.

1990 • 110 citations

Beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase. Comparison with the phosphodiesterase family.

1990 • 108 citations

G protein-effector coupling: binding of rod phosphodiesterase inhibitory subunit to transducin

1989 • 104 citations

Activation of retinal rod cyclic GMP‐phosphodiesterase by transducin: Characterization of the complex formed by phosphodiesterase inhibitor and transducin α‐subunit

1986 • 102 citations

Activation of cGMP phosphodiesterase in retinal rods: mechanism of interaction with the GTP-binding protein (transducin)

1989 • 94 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 94 citations

Activation mechanism of retinal rod cyclic GMP phosphodiesterase probed by fluorescein-labeled inhibitory subunit

1990 • 86 citations

A phosphodiesterase inhibitor specific to a subset of bovine retinal cones.

1990 • 75 citations

Active sites of the cyclic GMP phosphodiesterase γ‐subunit of retinal rod outer segments

1988 • 69 citations

Expression in bacteria of functional inhibitory subunit of retinal rod cGMP phosphodiesterase.

1989 • 62 citations

Interaction of the γ-subunit of retinal rod outer segment phosphodiesterase with transducin

1989 • 50 citations

A continuous fluorescence assay for cyclic nucleotide phosphodiesterase hydrolysis of cyclic GMP

1987 • 40 citations

Binding of the γ-subunit of retinal rod-outer-segment phosphodiesterase with both transducin and the catalytic subunits of phosphodiesterase

1990 • 21 citations

Detection of heterologous fusion proteins in Escherichia coli with a monoclonal antibody

1987 • 7 citations