Subunit stoichiometry of retinal rod cGMP phosphodiesterase

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision.

1981 • 740 citations

Dark Current and Photocurrent in Retinal Rods

1970 • 555 citations

Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments.

1979 • 448 citations

Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments.

1980 • 391 citations

Light-induced reduction of cytoplasmic free calcium in retinal rod outer segment

1985 • 381 citations

Light-activated phosphodiesterase of the rod outer segment. Kinetics and parameters of activation and deactivation.

1978 • 353 citations

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

1982 • 336 citations

Characterization of transducin from bovine retinal rod outer segments. II. Evidence for distinct binding sites and conformational changes revealed by limited proteolysis with trypsin.

1983 • 331 citations

One-step purification of mouse monoclonal antibodies from ascitic fluid by DEAE Affi-gel blue chromatography

1982 • 322 citations

High frequencies of antigen-specific hybridomas: dependence on immunization parameters and prediction by spleen cell analysis

1980 • 284 citations

Purification and properties of the light-activated cyclic nucleotide phosphodiesterase of rod outer segments

1975 • 271 citations

THE MOLECULAR MECHANISM OF VISUAL EXCITATION AND ITS RELATION TO THE STRUCTURE AND COMPOSITION OF THE ROD OUTER SEGMENT

1987 • 264 citations

Electrical activity of vertebrate photoreceptors

1970 • 260 citations

cGMP phosphodiesterase of retinal rods is regulated by two inhibitory subunits.

1988 • 246 citations

A light-activated GTPase in vertebrate photoreceptors: Regulation of light-activated cyclic GMP phosphodiesterase

1977 • 208 citations

Trigger and Amplification Mechanisms in Visual Phototransduction

1985 • 196 citations

The spectrophotometric determination of protein at 210mμ

1959 • 193 citations

Amplitude, kinetics, and reversibility of a light-induced decrease in guanosine 3',5'-cyclic monophosphate in frog photoreceptor membranes.

1979 • 186 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 167 citations

Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its γ subunit and transducin

1986 • 151 citations

Molecular Properties of the cGMP Cascade of Vertebrate Photoreceptors

1987 • 137 citations

Activation mechanism of rod outer segment cyclic GMP phosphodiesterase. Release of inhibitor by the GTP/GTP-binding protein.

1983 • 117 citations

cGMP phosphodiesterase in rod and cone outer segments of the retina.

1985 • 115 citations

Parameters affecting ascites tumour formation in mice and monoclonal antibody production

1984 • 109 citations

G protein-effector coupling: binding of rod phosphodiesterase inhibitory subunit to transducin

1989 • 104 citations

Activation of retinal rod cyclic GMP‐phosphodiesterase by transducin: Characterization of the complex formed by phosphodiesterase inhibitor and transducin α‐subunit

1986 • 102 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 94 citations

Kinetic studies suggest that light-activated cyclic GMP phosphodiesterase is a complex with G-protein subunits

1986 • 93 citations

A critical reappraisal of Waddell's technique for ultraviolet spectrophotometric protein estimation

1983 • 90 citations

Cyclic GMP phosphodiesterase from bovine retina Amino acid sequence of the α‐subunit and nucleotide sequence of the corresponding cDNA

1987 • 89 citations

Characterization of transducin from bovine retinal rod outer segments. The role of sulfhydryl groups.

1984 • 78 citations

The membrane binding domain of rod cGMP phosphodiesterase is posttranslationally modified by methyl esterification at a C-terminal cysteine.

1989 • 75 citations

Light-activated GTPase in vertebrate photoreceptors

1977 • 74 citations

Chemical cross-linking of bovine retinal transducin and cGMP phosphodiesterase.

1988 • 71 citations

Comparison of the phosphodiesterase inhibitory subunit interactions of frog and bovine rod outer segments

1989 • 53 citations

Characterization of transducin from bovine retinal rod outer segments. Use of monoclonal antibodies to probe the structure and function of the subunit.

1988 • 51 citations

Rapid declines in cyclic GMP of rod outer segments of intact frog photoreceptors after illumination.

1986 • 42 citations

Changes in cGMP concentration correlate with some, but not all, aspects of the light-regulated conductance of frog rod photoreceptors.

1986 • 30 citations

Transducin: Structure, function and role in phototransduction

1987 • 26 citations

Immological determination of transducin content in retinas exhibiting inherited degeneration

1987 • 22 citations

A freezing method for cell fusions to distribute and reduce labor and permit more thorough early evaluation of hybridomas

1984 • 15 citations