THE MOLECULAR MECHANISM OF VISUAL EXCITATION AND ITS RELATION TO THE STRUCTURE AND COMPOSITION OF THE ROD OUTER SEGMENT

Physics of chemoreception

1977 • 1,844 citations

Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

1986 • 1,702 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Responses of retinal rods to single photons.

1979 • 971 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Bacteriorhodopsin and Related Pigments of Halobacteria

1982 • 767 citations

Lateral diffusion of rhodopsin in the photoreceptor membrane

1974 • 658 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Tautomeric Forms of Metarhodopsin

1963 • 602 citations

Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes

1980 • 561 citations

The Drosophila ninaE gene encodes an opsin

1985 • 545 citations

The structure of bovine rhodopsin

1983 • 513 citations

Isolation and structure of a rhodopsin gene from D. melanogaster

1985 • 481 citations

The electrical response of turtle cones to flashes and steps of light

1974 • 471 citations

Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments.

1980 • 391 citations

A rhodopsin is the functional photoreceptor for phototaxis in the unicellular eukaryote Chlamydomonas

1984 • 372 citations

Light-activated phosphodiesterase of the rod outer segment. Kinetics and parameters of activation and deactivation.

1978 • 353 citations

Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate

1984 • 337 citations

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

1982 • 336 citations

Molecular biology of the visual pigments

1986 • 335 citations

Kinetics of the Photocurrent of Retinal Rods

1972 • 334 citations

An external point-charge model for wavelength regulation in visual pigments

1979 • 323 citations

myo-inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors

1984 • 310 citations

Lateral Diffusion of Visual Pigment in Photoreceptor Disk Membranes

1974 • 302 citations

Primary structure of the α-subunit of transducin and its relationship to ras proteins

1985 • 291 citations

Characterization of bovine rod outer segment G-protein.

1982 • 281 citations

Sequence of the Alpha Subunit of Photoreceptor G Protein: Homologies Between Transducin, ras , and Elongation Factors

1985 • 276 citations

Identification of Specific Transducin α Subunits in Retinal Rod and Cone Photoreceptors

1986 • 272 citations

Purification and properties of the light-activated cyclic nucleotide phosphodiesterase of rod outer segments

1975 • 271 citations

Photoisomerization, energy storage, and charge separation: A model for light energy transduction in visual pigments and bacteriorhodopsin

1979 • 270 citations

Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium

1982 • 259 citations

Microspectrophotometry of Photoreceptors

1972 • 254 citations

Absorption spectra and linear dichroism of some amphibian photoreceptors.

1975 • 250 citations

The structure of rhodopsin and the rod outer segment disk membrane

1983 • 248 citations

Interactions between photoexcited rhodopsin and GTP-binding protein: kinetic and stoichiometric analyses from light-scattering changes.

1981 • 247 citations

A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments

1979 • 232 citations

Cyclic GMP directly regulates a cation conductance in membranes of bovine rods by a cooperative mechanism.

1985 • 230 citations

The control of phosphodiesterase in rod disk membranes: Kinetics, possible mechanisms and significance for vision

1979 • 224 citations

In Situ Microspectrophotometric Studies on the Pigments of Single Retinal Rods

1962 • 222 citations

Millisecond activation of transducin in the cyclic nucleotide cascade of vision

1984 • 211 citations

Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase

1986 • 205 citations

Trigger and Amplification Mechanisms in Visual Phototransduction

1985 • 196 citations

Membrane-dependent guanine nucleotide binding and GTPase activities of soluble protein from bovine rod cell outer segments.

1979 • 183 citations

Magnitude of increase in retinal cGMP metabolic flux determined by 18O incorporation into nucleotide alpha-phosphoryls corresponds with intensity of photic stimulation.

1983 • 171 citations

GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence.

1985 • 169 citations

Phosphorylation of rhodopsin and quenching of cyclic GMP phosphodiesterase activation by ATP at weak bleaches.

1983 • 165 citations

Role of calcium in regulating the cyclic GMP cascade of phototransduction in retinal rods.

1986 • 160 citations

X-ray diffraction studies of retinal rods. I. Structure of the disc membrane, effect of illumination

1975 • 150 citations

Planar liquid-like arrangement of photopigment molecules in frog retinal receptor disk membranes

1969 • 150 citations

Cyclic GMP is involved in the excitation of invertebrate photoreceptors

1986 • 147 citations

Mechanism of ATP quench of phosphodiesterase activation in rod disc membranes.

1983 • 144 citations

Guanylate cyclase of isolated bovine retinal rod axonemes

1979 • 137 citations

Light-induced binding of guanosinetriphosphatase to bovine photoreceptor membranes: effect of limited proteolysis of the membranes

1981 • 136 citations

Neutron diffraction studies of retinal rod outer segment membranes

1976 • 134 citations

Restrictions on rotational and translational diffusion of pigment in the membranes of a rhabdomeric photoreceptor.

1977 • 132 citations

Phosphatidylinositol 4,5-bisphosphate: Light-mediated breakdown in the vertebrate retina

1984 • 129 citations

Effects of detergents and high pressures upon the metarhodopsin I.dbr.metarhodopsin II equilibrium

1974 • 118 citations

Temperature and pH dependence of the metarhodopsin I-metarhodopsin II kinetics and equilibria in bovine rod disk membrane suspensions

1984 • 117 citations

Membrane structure changes in rod outer segments associated with rhodopsin bleaching

1974 • 109 citations

Deprotonation of the Schiff base of rhodopsin is obligate in the activation of the G protein.

1986 • 108 citations

GTP hydrolysis in intact rod outer segments and the transmitter cycle in visual excitation

1979 • 108 citations

Chapter 10 Interactions of Rod Cell Proteins with the Disk Membrane: Influence of Light, Ionic Strength, and Nucleotides

1981 • 106 citations

An analysis of lamellar x-ray diffraction from disordered membrane multilayers with application to data from retinal rod outer segments

1975 • 98 citations

Transverse location of the retinal chromophore of rhodopsin in rod outer segment disc membranes

1982 • 96 citations

Kinetic studies suggest that light-activated cyclic GMP phosphodiesterase is a complex with G-protein subunits

1986 • 93 citations

Retinal rod GTPase turnover rate increases with concentration: A key to the control of visual excitation?

1987 • 93 citations

Gain, speed and sensitivity of GTP binding vs PDE activation in visual excitation

1982 • 86 citations

Link between rhodopsin and disk membrane cyclic nucleotide phosphodiesterase. Action spectrum and sensitivity to illumination

1975 • 83 citations

THE ROLE OF DOCOSAHEXAENOIC ACID (22:6ω3) IN BIOLOGICAL MEMBRANES: EXAMPLES FROM PHOTORECEPTORS AND MODEL MEMBRANE BILAYERS11This work was supported by grants from the National Eye Institute.

1986 • 83 citations

Cyclic GMP releases calcium from disc membranes of vertebrate photoreceptors.

1981 • 82 citations

The orientation of the chromophore of vertebrate rhodopsin in the “meta” intermediate states and the reversibility of the meta II-meta III transition

1979 • 73 citations

The thermal decay of the intermediates of rhodopsin in situ

1968 • 72 citations

Interaction between photoexcited rhodopsin and peripheral enzymes in frog retinal rods

1983 • 65 citations

The Chemistry of Vision

1982 • 64 citations

Light-dependent conformational change at rhodopsin's cytoplasmic surface detected by increased susceptibility to proteolysis

1982 • 61 citations

THE STRUCTURE OF RHODOPSIN AND ITS DISPOSITION IN THE ROD OUTER SEGMENT DISK MEMBRANE*

1979 • 61 citations

Diamagnetic anisotropy and orientation of alpha helix in frog rhodopsin and meta II intermediate.

1978 • 60 citations

Phosphorylation at sites near rhodopsin'scarboxyl-terminus regulates light initiated CGMP hydrolysis

1984 • 60 citations

Chapter 9 Control of Rod Disk Membrane Phosphodiesterase and a Model for Visual Transduction

1981 • 59 citations

FLASH PHOTOLYSIS OF ROD PARTICLE SUSPENSIONS

1964 • 59 citations

Orientation of rhodopsin alpha-helices in in retinal rod outer segment membranes studied by infrared linear dichroism.

1979 • 59 citations

Influence of light and calcium on guanosine 5'-triphosphate in isolated frog rod outer segments.

1979 • 58 citations

Kinship of cephalopod photoreceptor G‐protein with vertebrate transducin

1986 • 58 citations

Physiological evidence that light-mediated decrease in cyclic GMP is an intermediary process in retinal rod transduction.

1982 • 58 citations

Functional exchange of components between light-activated photoreceptor phosphodiesterase and hormone-activated adenylate cyclase systems.

1982 • 57 citations

Predictive value of the analogy between hormone‐sensitive adenylate cyclase and light‐sensitive photoreceptor cyclic GMP Phosphodiesterase: A specific role for a light‐sensitive GTPase as a component in the activation sequence

1979 • 56 citations

EFFECT OF FLASH ILLUMINATION ON RHODOPSIN IN SOLUTION

1958 • 55 citations

Protons suppress the dark current of frog retinal rods.

1984 • 53 citations

Birefringence, Dichroism and Rod Outer Segment Structure

1975 • 47 citations

Visual Adaptation: Effects of Externally Applied Retinal on the Light-Adapted, Isolated Skate Retina

1976 • 44 citations

Ionic Conductances in Rod Photoreceptors

1987 • 42 citations

The role of metarhodopsin in the generation of spontaneous quantum bumps in ultraviolet receptors of Limulus median eye. Evidence for reverse reactions into an active state.

1985 • 42 citations

The Nature and Identity of the Internal Excitational Transmitter of Vertebrate Phototransduction

1987 • 41 citations

Surfaces of rod photoreceptor disk membranes: light-activated enzymes.

1982 • 41 citations

The Structure, Spectra, and Reactivity of Visual Pigments

1972 • 38 citations

Excitation and adaptation of Limulus photo-receptors by light and Inositol 1,4,5-trisphosphate

1986 • 34 citations

Mechanism of cGMP control in retinal rod outer segments

1984 • 20 citations

Cycloheptatrienylidene analog of 11-cis retinal. Formation of pigment in photoreceptor membranes.

1984 • 19 citations

Separation and characterisation of light scattering transients from rod outer segments of vertebrate photoreceptors: design and performance of a Multi Angle Flash Photolysis Apparatus (MAFPA)

1985 • 15 citations

Chapter 1 The Photocurrent and Dark Current of Retinal Rods

1981 • 15 citations

X₅. Flash Photolysis of Visual Pigments

1960 • 9 citations

Homology between light-activated photoreceptor phosphodiesterase and hormone-activated adenylate cyclase systems.

1985 • 7 citations

Visual Receptor Transduction

1987 • 2 citations