Molecular mechanism of visual transduction

Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

1986 • 1,702 citations

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision.

1981 • 740 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions

1988 • 634 citations

Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.

1982 • 618 citations

Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes

1980 • 561 citations

The structure of bovine rhodopsin

1983 • 513 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

The Visual Process: Excitatory Mechanisms in the Primary Receptor Cells

1972 • 482 citations

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

1987 • 478 citations

Actin Polymerization and ATP Hydrolysis

1987 • 439 citations

Rhodopsin and bacteriorhodopsin: structure—function relationships

1982 • 430 citations

Fluoroaluminates activate transducin‐GDP by mimicking the γ‐phosphate of GTP in its binding site

1985 • 420 citations

Two adjacent cysteine residues in the C‐terminal cytoplasmic fragment of bovine rhodopsin are palmitylated

1988 • 409 citations

Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.

1987 • 383 citations

Light-induced reduction of cytoplasmic free calcium in retinal rod outer segment

1985 • 381 citations

Light dependent phosphorylation of rhodopsin by ATP

1972 • 370 citations

Light-activated phosphodiesterase of the rod outer segment. Kinetics and parameters of activation and deactivation.

1978 • 353 citations

Cyclic GMP-sensitive conductance of retinal rods consists of aqueous pores

1986 • 336 citations

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

1982 • 336 citations

Molecular biology of the visual pigments

1986 • 335 citations

Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane

1986 • 335 citations

Phosphorylation of Frog Photoreceptor Membranes induced by Light

1972 • 332 citations

Characterization of transducin from bovine retinal rod outer segments. II. Evidence for distinct binding sites and conformational changes revealed by limited proteolysis with trypsin.

1983 • 331 citations

An external point-charge model for wavelength regulation in visual pigments

1979 • 323 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

Light-regulated binding of rhodopsin kinase and other proteins to cattle photoreceptor membranes

1978 • 313 citations

Characterization of bovine rod outer segment G-protein.

1982 • 281 citations

Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.

1987 • 276 citations

Purification and properties of the light-activated cyclic nucleotide phosphodiesterase of rod outer segments

1975 • 271 citations

THE MOLECULAR MECHANISM OF VISUAL EXCITATION AND ITS RELATION TO THE STRUCTURE AND COMPOSITION OF THE ROD OUTER SEGMENT

1987 • 264 citations

Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium

1982 • 259 citations

ATP mediates rapid reversal of cyclic GMP phosphodiesterase activation in visual receptor membranes

1980 • 251 citations

Interactions between photoexcited rhodopsin and GTP-binding protein: kinetic and stoichiometric analyses from light-scattering changes.

1981 • 247 citations

cGMP phosphodiesterase of retinal rods is regulated by two inhibitory subunits.

1988 • 246 citations

Identification, purification, and functional reconstitution of the cyclic GMP-dependent channel from rod photoreceptors.

1987 • 239 citations

Retinal S Antigen Identified as the 48K Protein Regulating Light-Dependent Phosphodiesterase in Rods

1985 • 234 citations

Progress in retinal research

1987 • 231 citations

Cyclic GMP directly regulates a cation conductance in membranes of bovine rods by a cooperative mechanism.

1985 • 230 citations

Energy uptake in the first step of visual excitation

1979 • 216 citations

Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin.

1984 • 214 citations

Millisecond activation of transducin in the cyclic nucleotide cascade of vision

1984 • 211 citations

Primary and secondary structure of bovine retinal S antigen (48-kDa protein).

1987 • 200 citations

Trigger and Amplification Mechanisms in Visual Phototransduction

1985 • 196 citations

Molecular Biology of Visual Pigments

1987 • 168 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 167 citations

Calcium modulation of cyclic GMP synthesis in rat visual cells

1982 • 153 citations

Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its γ subunit and transducin

1986 • 151 citations

Light-Induced Interaction between Rhodopsin and the GTP-Binding Protein. Metarhodopsin II Is the Major Photoproduct Involved

1982 • 142 citations

ON THE MECHANISM OF WAVELENGTH REGULATION IN VISUAL PIGMENTS

1985 • 138 citations

Molecular Properties of the cGMP Cascade of Vertebrate Photoreceptors

1987 • 137 citations

Guanylate cyclase of isolated bovine retinal rod axonemes

1979 • 137 citations

Light-induced binding of guanosinetriphosphatase to bovine photoreceptor membranes: effect of limited proteolysis of the membranes

1981 • 136 citations

The G-protein of retinal rod outer segments (transducin). Mechanism of interaction with rhodopsin and nucleotides.

1985 • 122 citations

Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.

1985 • 114 citations

Chapter 10 Interactions of Rod Cell Proteins with the Disk Membrane: Influence of Light, Ionic Strength, and Nucleotides

1981 • 106 citations

Stereochemistry of the guanyl nucleotide binding site of transducin probed by phosphorothioate analogs of GTP and GDP

1985 • 102 citations

Activation of retinal rod cyclic GMP‐phosphodiesterase by transducin: Characterization of the complex formed by phosphodiesterase inhibitor and transducin α‐subunit

1986 • 102 citations

Stabilization of microtubules by inorganic phosphate and its structural analogs, the fluoride complexes of aluminum and beryllium

1988 • 96 citations

Measurements of fast light-induced light-scattering and -absorption changes in outer segments of vertebrate light sensitive rod cells

1976 • 95 citations

Molecular cloning of the S-antigen cDNA from bovine retina

1987 • 94 citations

cGMP-dependent cation channel of retinal rod outer segments

1987 • 94 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 94 citations

Retinal rod GTPase turnover rate increases with concentration: A key to the control of visual excitation?

1987 • 93 citations

Cyclic GMP and the permeability of the disks of the frog photoreceptors.

1979 • 92 citations

Sequence analysis of bovine retinal S‐antigen

1986 • 92 citations

Cyclic GMP phosphodiesterase from bovine retina Amino acid sequence of the α‐subunit and nucleotide sequence of the corresponding cDNA

1987 • 89 citations

An ordered membrane-cytoskeleton network in squid photoreceptor microvilli

1982 • 84 citations

Cyclic GMP releases calcium from disc membranes of vertebrate photoreceptors.

1981 • 82 citations

Sub‐second turnover of transducin GTPase in bovine rod outer segments A light scattering study

1988 • 70 citations

Inhibition of H+-transporting ATPase by formation of a tight nucleoside diphosphate-fluoroaluminate complex at the catalytic site.

1988 • 66 citations

Interaction between photoexcited rhodopsin and peripheral enzymes in frog retinal rods

1983 • 65 citations

cGMP-dependent channel protein from photoreceptor membranes: single-channel activity of the purified and reconstituted protein.

1988 • 64 citations

Visual Pigment Homologies Revealed by DNA Hybridization

1986 • 63 citations

ORIENTATION OF AROMATIC RESIDUES IN RHODOPSIN. ROTATION OF ONE TRYPTOPHAN UPON THE META I→META II TRANSITION AFTER ILLUMINATION

1979 • 63 citations

X-ray diffraction studies of retinal rods. II. Light effect on the osmotic properties

1975 • 58 citations

Gigaseal patch clamp recordings from outer segments of intact retinal rods

1982 • 58 citations

A role for calcium in adaptation

1988 • 51 citations

The Nature and Identity of the Internal Excitational Transmitter of Vertebrate Phototransduction

1987 • 41 citations

Guanine nucleotides and magnesium dependence of the association states of the subunits of transducin

1984 • 38 citations

Rapid calcium release and proton uptake at the disk membrane of isolated cattle rod outer segments. 1. Stoichiometry of light-stimulated calcium release and proton uptake

1981 • 35 citations

Contribution of the guanosinetriphosphatase activity of G-protein to termination of light-activated guanosine cyclic 3',5'-phosphate hydrolysis in retinal rod outer segments

1988 • 31 citations

Light and GTP dependence of transducin solubility in retinal rods

1988 • 27 citations

On the role of transducin GTPase in the quenching of a phosphodiesterase cascade of vision

1987 • 24 citations

Visual Signal Transduction; The Cycle of Transducin Shuttling between Rhodopsin and cGMP Phosphodiesterase

1988 • 20 citations

Rapid calcium release and proton uptake at the disk membrane of isolated cattle rod outer segments. 2. Kinetics of light-stimulated calcium release and proton uptake

1981 • 16 citations

The transducin cascade is involved in the light-induced structural changes observed by neutron diffraction on retinal rod outer segments

1987 • 9 citations