Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

2001 • 4,399 citations

Inflammation, stress, and diabetes

2005 • 3,786 citations

Reactive oxygen species have a causal role in multiple forms of insulin resistance

2006 • 2,397 citations

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

2002 • 2,244 citations

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

2002 • 2,164 citations

Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

2003 • 2,035 citations

Mitochondrial Dysfunction and Type 2 Diabetes

2005 • 1,950 citations

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

2003 • 1,893 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

2008 • 1,814 citations

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

1997 • 1,695 citations

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

2005 • 1,670 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain

2002 • 1,500 citations

Banting Lecture 2001

2002 • 1,445 citations

Generation of reactive oxygen species by the mitochondrial electron transport chain

2002 • 1,208 citations

Inflammation, stress, and diabetes

2005 • 1,203 citations

Radical-free biology of oxidative stress

2008 • 1,143 citations

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

2006 • 1,113 citations

Hydrogen Peroxide: A Signaling Messenger

2006 • 1,083 citations

Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

2005 • 859 citations

Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction

2006 • 846 citations

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

2008 • 782 citations

Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury

2004 • 750 citations

What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

1992 • 664 citations

Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

2007 • 557 citations

The Molecular Basis for Oxidative Stress-Induced Insulin Resistance

2005 • 556 citations

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism

2008 • 531 citations

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

2008 • 518 citations

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

2007 • 505 citations

Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

2007 • 504 citations

S-glutathionylation in protein redox regulation

2007 • 471 citations

Mitochondrial filaments and clusters as intracellular power-transmitting cables

2001 • 460 citations

Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency

2005 • 457 citations

Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of α-Lipoic Acid

2001 • 402 citations

Reversible Glutathionylation of Complex I Increases Mitochondrial Superoxide Formation

2003 • 387 citations

Proposed Mechanisms for the Induction of Insulin Resistance by Oxidative Stress

2005 • 367 citations

Obesity-Related Derangements in Metabolic Regulation

2006 • 349 citations

A small-molecule inhibitor of skeletal muscle myosin II

2001 • 342 citations

Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents

2006 • 308 citations

Type II skeletal myofibers possess unique properties that potentiate mitochondrial H₂O₂ generation

2005 • 302 citations

A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

2005 • 259 citations

The role of intramuscular lipid in insulin resistance

2003 • 250 citations

Generating, Partitioning, Targeting and Functioning of Superoxide in Mitochondria

1997 • 220 citations

Fatty Acid-induced Insulin Resistance in L6 Myotubes Is Prevented by Inhibition of Activation and Nuclear Localization of Nuclear Factor κB

2004 • 215 citations

Persistent S-Nitrosation of Complex I and Other Mitochondrial Membrane Proteins by S-Nitrosothiols but Not Nitric Oxide or Peroxynitrite

2006 • 195 citations

Striking Differences Between the Kinetics of Regulation of Respiration by ADP in Slow‐Twitch and Fast‐Twitch Muscles In Vivo

1996 • 188 citations

Disruption of mitochondrial redox circuitry in oxidative stress

2006 • 169 citations

Control of mitochondrial membrane potential and ROS formation by reversible phosphorylation of cytochrome c oxidase.

2002 • 168 citations

Reduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humans

2003 • 162 citations

Cell‐permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis

2006 • 160 citations

Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes

1999 • 151 citations

Induction of Endogenous Uncoupling Protein 3 Suppresses Mitochondrial Oxidant Emission during Fatty Acid-supported Respiration

2007 • 149 citations

Detection of Reactive Oxygen Species-sensitive Thiol Proteins by Redox Difference Gel Electrophoresis

2007 • 141 citations

Mitochondrial uncouplers with an extraordinary dynamic range

2007 • 140 citations

Exercise training and the antioxidant α-lipoic acid in the treatment of insulin resistance and type 2 diabetes

2005 • 139 citations

Effect of oxidative stress on dynamics of mitochondrial reticulum

2006 • 128 citations

R-α-Lipoic Acid Action on Cell Redox Status, the Insulin Receptor, and Glucose Uptake in 3T3-L1 Adipocytes

2002 • 111 citations

Cooperation of a "reactive oxygen cycle" with the Q cycle and the proton cycle in the respiratory chain--superoxide generating and cycling mechanisms in mitochondria.

1999 • 110 citations

Interactions of exercise training and α-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats

2004 • 88 citations

Mitochondrial Targeting with Antioxidant Peptide SS-31 Prevents Mitochondrial Depolarization, Reduces Islet Cell Apoptosis, Increases Islet Cell Yield, and Improves Posttransplantation Function

2006 • 78 citations

Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats

2001 • 68 citations