The role of intramuscular lipid in insulin resistance

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

1963 • 5,061 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

The hormone resistin links obesity to diabetes

2001 • 4,720 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

2001 • 2,534 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

2001 • 1,903 citations

The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization

1981 • 1,728 citations

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

2002 • 1,540 citations

The theoretical bases of indirect calorimetry: A review

1988 • 1,536 citations

Mechanism of free fatty acid-induced insulin resistance in humans.

1996 • 1,507 citations

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

2002 • 1,345 citations

Protein kinase C activation and the development of diabetic complications.

1998 • 1,328 citations

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

1999 • 1,300 citations

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

1999 • 1,267 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 • 1,256 citations

Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action

1997 • 1,133 citations

Effect of fatty acids on glucose production and utilization in man.

1983 • 1,056 citations

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

1999 • 1,052 citations

Mechanisms of fatty acid-induced inhibition of glucose uptake.

1994 • 1,049 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

2000 • 978 citations

Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid

1991 • 976 citations

Subcutaneous Abdominal Fat and Thigh Muscle Composition Predict Insulin Sensitivity Independently of Visceral Fat

1997 • 972 citations

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

1999 • 891 citations

The role of TNFα and TNF receptors in obesity and insulin resistance

1999 • 771 citations

Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles

1964 • 729 citations

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

2001 • 728 citations

Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells

1995 • 702 citations

Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo

1999 • 694 citations

Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus

2000 • 676 citations

Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling

1997 • 669 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

2002 • 614 citations

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

2000 • 605 citations

Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects

2001 • 591 citations

Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate

1999 • 590 citations

Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats

1991 • 586 citations

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

2002 • 529 citations

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

1995 • 524 citations

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

1998 • 506 citations

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.

1991 • 506 citations

Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.

1994 • 486 citations

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1999 • 483 citations

Interaction between glucose and free fatty acid metabolism in human skeletal muscle.

1993 • 476 citations

Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

1998 • 447 citations

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

2000 • 439 citations

Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

1997 • 434 citations

Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase

1996 • 404 citations

Mechanisms of Liver and Muscle Insulin Resistance Induced by Chronic High-Fat Feeding

1997 • 402 citations

Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects

1996 • 397 citations

Effects of Intravenous and Dietary Lipid Challenge on Intramyocellular Lipid Content and the Relation With Insulin Sensitivity in Humans

2001 • 370 citations

Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats

2001 • 348 citations

Insulin Receptor Substrate-1 Phosphorylation and Phosphatidylinositol 3-Kinase Activity in Skeletal Muscle From NIDDM Subjects After In Vivo Insulin Stimulation

1997 • 347 citations

Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells

2002 • 325 citations

Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis

1993 • 325 citations

Skeletal muscle utilization of free fatty acids in women with visceral obesity.

1995 • 324 citations

Prolonged Inhibition of Muscle Carnitine Palmitoyltransferase-1 Promotes Intramyocellular Lipid Accumulation and Insulin Resistance in Rats

2001 • 316 citations

Role of the glucosamine pathway in fat-induced insulin resistance.

1997 • 315 citations

Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat

1997 • 315 citations

AICAR Administration Causes an Apparent Enhancement of Muscle and Liver Insulin Action in Insulin-Resistant High-Fat-Fed Rats

2002 • 293 citations

Gene Expression of GLUT4 in Skeletal Muscle From Insulin-Resistant Patients With Obesity, IGT, GDM, and NIDDM

1992 • 276 citations

Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle

2000 • 274 citations

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

1990 • 273 citations

Signalling aspects of insulin resistance in skeletal muscle

2000 • 270 citations

THE GLUCOSE FATTY ACID CYCLE IN OBESITY AND MATURITY ONSET DIABETES MELLITUS

1965 • 269 citations

Intramyocellular Lipid Is Associated With Resistance to In Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human Skeletal Muscle

2001 • 263 citations

Long-Term (5-Year) Effects of a Reduced-Fat Diet Intervention in Individuals With Glucose Intolerance

2001 • 238 citations

Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity

1997 • 235 citations

Ceramide impairs the insulin-dependent membrane recruitment of Protein Kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells

2001 • 231 citations

A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat

1994 • 217 citations

Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats

2001 • 202 citations

Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans.

1999 • 198 citations

Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme A.

1992 • 191 citations

Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.

1992 • 184 citations

Leptin Activates Cardiac Fatty Acid Oxidation Independent of Changes in the AMP-activated Protein Kinase-Acetyl-CoA Carboxylase-Malonyl-CoA Axis

2002 • 179 citations

Diet-Induced Muscle Insulin Resistance in Rats Is Ameliorated by Acute Dietary Lipid Withdrawal or a Single Bout of Exercise: Parallel Relationship Between Insulin Stimulation of Glucose Uptake and Suppression of Long-Chain Fatty Acyl-CoA

1997 • 173 citations

Thiazolidinediones Increase Plasma-Adipose Tissue FFA Exchange Capacity and Enhance Insulin-Mediated Control of Systemic FFA Availability

2001 • 171 citations

Increased Efficiency of Fatty Acid Uptake Contributes to Lipid Accumulation in Skeletal Muscle of High Fat-Fed Insulin-Resistant Rats

2002 • 169 citations

The Role of Long-Chain Fatty Acyl-CoA Esters in β-Cell Signal Transduction

2000 • 159 citations

LIPOLYSIS:Contribution from Regional Fat

1997 • 156 citations

Sphingomyelin and ceramide as regulators of development and lifespan

2001 • 155 citations

Sphingomyelinase and Ceramide Suppress Insulin-induced Tyrosine Phosphorylation of the Insulin Receptor Substrate-1

1996 • 153 citations

A Role for Protein Phosphatase 2A–Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate

2001 • 153 citations

Altered Myocellular and Abdominal Fat Partitioning Predict Disturbance in Insulin Action in HIV Protease Inhibitor-Related Lipodystrophy

2002 • 150 citations

Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle

2000 • 144 citations

Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

2000 • 136 citations

PPARγ activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes

1998 • 134 citations

Plasma Free Fatty Acid Uptake and Oxidation Are Already Diminished in Subjects at High Risk for Developing Type 2 Diabetes

2001 • 132 citations

Perspective: Hexosamines and Nutrient Sensing

2000 • 131 citations

Systemic and regional free fatty acid metabolism in type 2 diabetes

2001 • 126 citations

The insulin sensitizer, BRL 49653, reduces systemic fatty acid supply and utilization and tissue lipid availability in the rat

1997 • 121 citations

Long-Chain Acyl CoA Regulation of Protein Kinase C and Fatty Acid Potentiation of Glucose-Stimulated Insulin Secretion in Clonalβ -Cells¹

2000 • 118 citations

Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat

1999 • 116 citations

Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding

1999 • 112 citations

Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat

1998 • 110 citations

Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro

2000 • 108 citations

Protein kinase C modulates insulin action in human skeletal muscle

2000 • 102 citations

Various phosphodiesterase subtypes mediate the in vivo antilipolytic effect of insulin on adipose tissue and skeletal muscle in man

1998 • 90 citations

Effects of high fat-feeding to rats on the interrelationship of body weight, plasma insulin, and fatty acyl-coenzyme a esters in liver and skeletal muscle

1992 • 83 citations

Analysis of Acyl Coenzyme A Binding to the Transcription Factor FadR and Identification of Amino Acid Residues in the Carboxyl Terminus Required for Ligand Binding

1995 • 82 citations

Metabolic Impairment Precedes Insulin Resistance in Skeletal Muscle During High-Fat Feeding in Rats

1996 • 76 citations

A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat

1994 • 74 citations

The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs)

1997 • 74 citations

Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid.

1999 • 70 citations

Free fatty acid uptake in the myocardium and skeletal muscle using fluorine-18-fluoro-6-thia-heptadecanoic acid.

1998 • 65 citations

Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653

1997 • 61 citations

Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice

2002 • 60 citations

High Hydrostatic Pressure Induces the Dissociation of cpn60 Tetradecamers and Reveals a Plasticity of the Monomers

1995 • 59 citations

Myocardial fatty acid oxidation in patients with impaired glucose tolerance

2001 • 58 citations

Role of non-esterified fatty acids in the pathogenesis of Type 2 diabetes mellitus

1998 • 57 citations

Cellular Mechanism of Nutritionally Induced Insulin Resistance: The Desert Rodent Psammomys obesus and Other Animals in which Insulin Resistance leads to Detrimental Outcome

1998 • 56 citations

Development and initial evaluation of a novel method for assessing tissue-specific plasma free fatty acid utilization in vivo using (R)-2-bromopalmitate tracer

1999 • 55 citations

Palmitoyl‐CoA and the acyl‐CoA thioester of the carcinogenic peroxisome‐proliferator ciprofibrate potentiate diacylglycerol‐activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme

1990 • 53 citations

Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-θ localization

2000 • 51 citations

Local factors modulate tissue-specific NEFA utilization: assessment in rats using 3H-(R)-2-bromopalmitate.

2000 • 48 citations

Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats

1997 • 47 citations

Perspective: Hexosamines and Nutrient Sensing

2000 • 46 citations

Metabolic impairment precedes insulin resistance in skeletal muscle during high-fat feeding in rats

1996 • 36 citations

Effect of fatty acids and their acyl-CoA esters on protein kinase C activity in fibroblasts: Possible implications in fatty acid oxidation defects

1994 • 31 citations

Free Fatty Acids Induce Peripheral Insulin Resistance Without Increasing Muscle Hexosamine Pathway Product Levels in Rats

2001 • 27 citations