Inflammation, stress, and diabetes

Biochemistry and molecular cell biology of diabetic complications

2001 • 8,707 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,391 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

A central role for JNK in obesity and insulin resistance

2002 • 3,225 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

Inflammation: the link between insulin resistance, obesity and diabetes

2003 • 2,083 citations

Mitochondrial Dysfunction and Type 2 Diabetes

2005 • 1,950 citations

Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin

2004 • 1,897 citations

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

1998 • 1,728 citations

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

2002 • 1,540 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes

2004 • 1,361 citations

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

1995 • 1,316 citations

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

2002 • 1,210 citations

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

2003 • 1,075 citations

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

2002 • 973 citations

Explaining How “High-Grade” Systemic Inflammation Accelerates Vascular Risk in Rheumatoid Arthritis

2003 • 922 citations

Emerging roles of PPARS in inflammation and immunity

2002 • 893 citations

SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2

2002 • 874 citations

Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors

2003 • 864 citations

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

2002 • 806 citations

Obesity, adiponectin and vascular inflammatory disease

2003 • 732 citations

The expression of TNF alpha by human muscle. Relationship to insulin resistance.

1996 • 727 citations

Diabetes mellitus : a fundamental and clinical text

2004 • 691 citations

Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

2001 • 674 citations

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

2004 • 632 citations

Insulin signaling pathways in time and space

2002 • 630 citations

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

2004 • 624 citations

The insulin signalling system and the IRS proteins

1997 • 582 citations

Increased oxidative stress in obesity and its impact on metabolic syndrome

2004 • 574 citations

LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response

2004 • 549 citations

Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

2001 • 536 citations

Leptin-specific patterns of gene expression in white adipose tissue

2000 • 519 citations

An Inflammatory Cascade Leading to Hyperresistinemia in Humans

2004 • 514 citations

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

2003 • 490 citations

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

2004 • 489 citations

Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes

2004 • 467 citations

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism

2003 • 467 citations

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes

2005 • 451 citations

Genetics and Pathophysiology of Human Obesity

2003 • 381 citations

The current biology of resistin

2004 • 380 citations

Inhibition of Insulin Sensitivity by Free Fatty Acids Requires Activation of Multiple Serine Kinases in 3T3-L1 Adipocytes

2004 • 336 citations

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

2004 • 334 citations

The Inherited Basis of Diabetes Mellitus: Implications for the Genetic Analysis of Complex Traits

2003 • 332 citations

A role for preadipocytes as macrophage‐like cells

1999 • 319 citations

Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

1997 • 314 citations

Fatty Acid Binding Proteins—The Evolutionary Crossroads of Inflammatory and Metabolic Responses

2004 • 301 citations

Role of nitric oxide in obesity-induced beta cell disease.

1997 • 287 citations

Requirement of JNK2 for Scavenger Receptor A-Mediated Foam Cell Formation in Atherogenesis

2004 • 277 citations

Cellular mechanism of insulin resistance: potential links with inflammation

2003 • 261 citations

Signal transduction by the JNK group of MAP kinases

2000 • 253 citations

Chronic Obstructive Pulmonary Disease, Asthma, and Risk of Type 2 Diabetes in Women

2004 • 252 citations

Nutrition, immunity and infection: From basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival

1996 • 249 citations

Modulation of the JNK Pathway in Liver Affects Insulin Resistance Status

2004 • 224 citations

The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes

2005 • 213 citations

Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation

2003 • 208 citations

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

2000 • 180 citations

Cell-mediated immunity in genetically obese (C57BL/6J ob/ob) mice

1980 • 178 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 165 citations

Are patients with asthma at increased risk of coronary heart disease?

2004 • 136 citations

Protein Kinase C and Lipid‐Induced Insulin Resistance in Skeletal Muscle

2002 • 121 citations

An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue

2004 • 118 citations

Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays.

1978 • 108 citations

Role of Ser/Thr kinases in the uncoupling of insulin signaling

2003 • 93 citations

Association of diabetes and hepatitis C infection: Epidemiologic evidence and pathophysiologic insights

2004 • 87 citations

Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

2005 • 86 citations

Prevention of fat-induced insulin resistance by salicylate

2001 • 81 citations

Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance

2004 • 78 citations

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

2002 • 50 citations

Molecular basis for insulin resistance: elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation

2009 • 46 citations

TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone

1997 • 45 citations

Preadipocyte conversion to macrophage. Evidence of plasticity

2003 • 45 citations

Pasteur's Quadrant and malnutrition

2001 • 36 citations