Differential effects of NMDA–receptor antagonists on long-term potentiation and hypoxic/hypoglycaemic excitotoxicity in hippocampal slices

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes

1988 • 1,415 citations

The Time Course of Glutamate in the Synaptic Cleft

1992 • 1,071 citations

Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data

1999 • 841 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

1998 • 621 citations

Excitotoxicity and the NMDA receptor -- still lethal after eight years

1995 • 504 citations

The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐<scp>d</scp>‐aspartate receptor in rat brain

1987 • 452 citations

Glutamate in CNS disorders as a target for drug development: an update

1998 • 423 citations

The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events

2001 • 411 citations

Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine

1989 • 408 citations

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

1993 • 318 citations

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies

1997 • 317 citations

Altered glutamatergic transmission in neurological disorders: From high extracellular glutamate to excessive synaptic efficacy

1997 • 308 citations

Comparative Effect of Transient Global Ischemia on Extracellular Levels of Glutamate, Glycine, and γ‐Aminobutyric Acid in Vulnerable and Nonvulnerable Brain Regions in the Rat

1991 • 299 citations

Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine.

1996 • 283 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex

1989 • 251 citations

The ischemic penumbra

1994 • 230 citations

Changes in Extracellular Concentrations of Glutamate, Aspartate, Glycine, Dopamine, Serotonin, and Dopamine Metabolites After Transient Global Ischemia in the Rabbit Brain

1991 • 211 citations

Mechanisms Underlying the Rapid Depolarization Produced by Deprivation of Oxygen and Glucose in Rat Hippocampal CA1 Neurons In Vitro

1997 • 204 citations

Modulation of N‐methyl‐D‐aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.

1990 • 199 citations

Modulation of learning processes by ionotropic glutamate receptor ligands

1995 • 181 citations

Control of NMDA Receptor Activation by a Glycine Transporter Co-Expressed inXenopusOocytes

1997 • 170 citations

Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits.

1991 • 162 citations

Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: Implications for neurodegenerative diseases

1996 • 157 citations

Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine

1996 • 139 citations

Effects of memantine and MK‐801 on NMDA‐induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices

1996 • 129 citations

Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization

1999 • 128 citations

Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic-ischemia

1991 • 117 citations

Effect of Delayed MK-801 (Dizocilpine) Treatment with or without Immediate Postischemic Hypothermia on Chronic Neuronal Survival after Global Forebrain Ischemia in Rats

1995 • 114 citations

Infusion of (+)-MK-801 and memantine — contrasting effects on radial maze learning in rats with entorhinal cortex lesion

1996 • 112 citations

NMDA‐receptor blockers but not NBQX, an AMPA‐receptor antagonist, inhibit spreading depression in the rat brain

1992 • 107 citations

Learning deficits induced by chronic intraventricular infusion of quinolinic acid — protection by MK-801 and memantine

1996 • 103 citations

Experimental ischemia induces a persistent depolarization blocked by decreased calcium and NMDA antagonists

1989 • 98 citations

MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis

1995 • 96 citations

The Glycine Antagonist GV150526 Protects Somatosensory Evoked Potentials and Reduces the Infarct Area in the MCAo Model of Focal Ischemia in the Rat

1997 • 88 citations

Noncompetitive NMDA Receptor Antagonists with Fast Open-Channel Blocking Kinetics and Strong Voltage-Dependency as Potential Therapeutic Agents for Alzheimer's Dementia

1995 • 87 citations

Role of Excitatory Amino Acid‐Mediated Ionic Fluxes in Traumatic Brain Injury

1995 • 82 citations

Inhibition of cortical spreading depression by L‐701,324, a novel antagonist at the glycine site of the N‐methyl‐D‐aspartate receptor complex

1996 • 71 citations

Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.

1992 • 63 citations

Memantine prevents quinolinic acid-induced hippocampal damage

1992 • 55 citations

The effects of mitochondrial failure upon cholinergic toxicity in the nucleus basalis

1996 • 53 citations

Whole cell and single channel analysis of the kinetics of glycine‐sensitive N‐methyl‐D‐aspartate receptor desensitization

1993 • 39 citations

Apparent Independent Action of Nimodipine and Glutamate Antagonists to Protect Cultured Neurons Against Glutamate-induced Damage

1996 • 39 citations

The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor

1996 • 37 citations

Role of Astrocytes in the Spreading Depression Signal Between Ischemic Core and Penumbra

1997 • 37 citations

A Glycine Site Antagonist, ZD9379, Reduces Number of Spreading Depressions and Infarct Size in Rats With Permanent Middle Cerebral Artery Occlusion

1998 • 37 citations

Comparison of glutamate antagonists in continuous multiple-trial and single-trial dark avoidance

1995 • 36 citations

Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551

1990 • 29 citations

The Effect of Cyclohexyladenosine on the Penischemic Increases of Hippocampal Glutamate and Glycine in the Rabbit

1992 • 25 citations

Therapeutic Window in Ischaemic Stroke

1997 • 14 citations

Differential effects of five glycine site antagonists on NMDA receptor desensitisation

1996 • 10 citations

Differential effect of NMDA and AMPA receptor blockade on protein synthesis in the rat infarct borderzone

2009 • 10 citations

Selective block of N‐methyl‐<scp>d</scp>‐aspartic acid (NMDA)‐evoked whole‐cell currents in mouse cultured spinal neurones by CGP 40116

1997 • 8 citations