Effects of memantine and MK‐801 on NMDA‐induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

The Time Course of Glutamate in the Synaptic Cleft

1992 • 1,071 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Effect of Ischemia on the In Vivo Release of Striatal Dopamine, Glutamate, and γ‐Aminobutyric Acid Studied by Intracerebral Microdialysis

1988 • 704 citations

Nonuniform Probability of Glutamate Release at a Hippocampal Synapse

1993 • 641 citations

The probability of transmitter release at a mammalian central synapse

1993 • 632 citations

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1992 • 626 citations

Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism

1986 • 416 citations

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

1989 • 347 citations

Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study

1991 • 303 citations

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

1995 • 300 citations

Comparative Effect of Transient Global Ischemia on Extracellular Levels of Glutamate, Glycine, and γ‐Aminobutyric Acid in Vulnerable and Nonvulnerable Brain Regions in the Rat

1991 • 299 citations

Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.

1994 • 283 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex

1989 • 251 citations

The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK‐801: a voltage clamp study on neuronal cells in culture

1989 • 215 citations

Mechanisms of blockade of excitatory amino acid receptor channels

1990 • 199 citations

MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices

1987 • 194 citations

Modulation of learning processes by ionotropic glutamate receptor ligands

1995 • 181 citations

Effects of phencyclidine, SKF 10,047 and related psychotomimetic agents on N‐methyl‐<scp>d</scp>‐aspartate receptor mediated synaptic responses in rat hippocampal slices

1987 • 170 citations

Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate (NMDA) receptor antagonist memantine in man

1995 • 155 citations

Effects of the Uncompetitive NMDA Receptor Antagonist Memantine on Hippocampal Long‐term Potentiation, Short‐term Exploratory Modulation and Spatial Memory in Awake, Freely Moving Rats

1996 • 145 citations

The Nitric Oxide ‐ Cyclic GMP Pathway and Synaptic Depression in Rat Hippocampal Slices

1994 • 141 citations

Efficacy and tolerability of memantine in patients with dementia syndrome. A double-blind, placebo controlled trial.

1991 • 124 citations

Memantine in the treatment of mild to moderate dementia syndrome. A double-blind placebo-controlled study.

1992 • 121 citations

Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic-ischemia

1991 • 117 citations

Different binding affinities of NMDA receptor channel blockers in various brain regions—Indication of NMDA receptor heterogeneity

1995 • 115 citations

Infusion of (+)-MK-801 and memantine — contrasting effects on radial maze learning in rats with entorhinal cortex lesion

1996 • 112 citations

Comparative Patch‐clamp Studies with Freshly Dissociated Rat Hippocampal and Striatal Neurons on the NMDA Receptor Antagonistic Effects of Amantadine and Memantine

1996 • 107 citations

Learning deficits induced by chronic intraventricular infusion of quinolinic acid — protection by MK-801 and memantine

1996 • 103 citations

Selective vulnerability of hippocampal CA1 neurons cannot be explained in terms of an increase in glutamate concentration during ischemia in the gerbil: Brain microdialysis study

1992 • 100 citations

Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands

1988 • 99 citations

MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis

1995 • 96 citations

Wirkungen oraler Memantin-Gaben auf die Parkinson-Symptomatik: Ergebnisse einer placebo-kontrollierten Multicenter-Studie

2008 • 95 citations

Striatal Protection Induced by Lesioning the Substantia Nigra of Rats Subjected to Focal Ischemia

1992 • 84 citations

Characterization of an N-methyl-d-aspartate receptor component of synaptic transmission in rat hippocampal slices

1987 • 78 citations

Are NMDA antagonistic properties relevant for antiparkinsonianlike activity in rats?—Case of amantadine and memantine

1994 • 75 citations

The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro

1988 • 71 citations

Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat

1994 • 49 citations

[Pharmacodynamics and pharmacokinetics of memantine].

1983 • 48 citations

Dopamine has inhibitory and accelerating effects on ischemia-induced neuronal cell damage in the rat striatum

1994 • 47 citations

A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons

1992 • 36 citations

NMDA Receptor‐dependent Transient Homo‐ and Heterosynaptic Depression in Picrotoxin‐treated Hippocampal Slices

1992 • 31 citations

Effects of memantine on synaptic transmission in the hippocampus in vitro.

1995 • 30 citations

Anticonvulsant effects of memantine and MK-801 in Guinea Pig hippocampal slices

1995 • 19 citations

[Memantine and neurogenic bladder disorders within the bounds of spastic conditions].

1982 • 17 citations

Glutamate, learning and dementia-selection of evidence

1994 • 17 citations