MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis

Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey

1983 • 1,898 citations

Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities

1969 • 1,043 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.

1990 • 647 citations

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1992 • 626 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

Noncompetitive excitatory amino acid receptor antagonists

1990 • 361 citations

Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study

1991 • 303 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

Excitatory amino acid antagonists

1991 • 240 citations

Contributory mechanisms in the causation of neurodegenerative disorders

1993 • 228 citations

Modulation of Glutamate Receptors: Molecular Mechanisms and Functional Implications

1989 • 198 citations

Glutamate transmission and toxicity in alzheimer's disease

1988 • 190 citations

The NMDA Receptor, NMDA Antagonists and Epilepsy Therapy

1992 • 165 citations

Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.

1989 • 164 citations

Neuroprotective effect of memantine demonstrated in vivo and in vitro

1990 • 157 citations

Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted?

1990 • 154 citations

Memantine in the treatment of mild to moderate dementia syndrome. A double-blind placebo-controlled study.

1992 • 121 citations

Nucleus basalis magnocellularis: optimal coordinates for selective reduction of choline acetyltransferase in frontal neocortex by ibotenic acid injections

1984 • 89 citations

Are NMDA antagonistic properties relevant for antiparkinsonianlike activity in rats?—Case of amantadine and memantine

1994 • 75 citations

Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat

1994 • 49 citations

Amantadine sulphate in treating Parkinson's disease: Clinical effects, psychometric tests and serum concentrations

1989 • 38 citations

Excitatory amino acid antagonists

1991 • 26 citations

Antiparkinsonian drugs and in vitro excitotoxicity

1992 • 23 citations

Amantadine increases striatal dopamine turnover in MPTP‐treated mice

1993 • 14 citations

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