A Glycine Site Antagonist, ZD9379, Reduces Number of Spreading Depressions and Infarct Size in Rats With Permanent Middle Cerebral Artery Occlusion

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

1944 • 2,580 citations

Viability thresholds and the penumbra of focal ischemia

1994 • 1,358 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

1986 • 1,257 citations

Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain.

1989 • 1,110 citations

Experimental studies of ischemic brain edema

1986 • 932 citations

Experimental studies of ischemic brain edema : a new experimental study of ischemic brain edema : 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

1986 • 770 citations

Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats.

1993 • 706 citations

The mechanism and applications of Leão's spreading depression of electroencephalographic activity

1974 • 518 citations

Clinical Experience With Excitatory Amino Acid Antagonist Drugs

1995 • 499 citations

The glycine site of the NMDA receptor — five years on

1993 • 440 citations

MECHANISM OF SPREADING CORTICAL DEPRESSION

1956 • 437 citations

Correlation between periinfarct DC shifts and ischaemic neuronal damage in rat

1993 • 400 citations

Repeated Negative DC Deflections in Rat Cortex following Middle Cerebral Artery Occlusion are Abolished by MK-801: Effect on Volume of Ischemic Injury

1992 • 361 citations

Spreading Cortical Depression of Leão

1959 • 351 citations

Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [¹⁴C]2-Deoxyglucose Phosphorylation

1986 • 334 citations

Evidence for a role of the N-methyl-d-aspartate (NMDA) receptor in cortical spreading depression in the rat

1988 • 321 citations

The Glycine Site on the NMDA Receptor: Structure-Activity Relationships and Therapeutic Potential

1994 • 320 citations

Characterization of Cortical Depolarizations Evoked in Focal Cerebral Ischemia

1993 • 305 citations

Cortical Negative DC Deflections following Middle Cerebral Artery Occlusion and KCl-Induced Spreading Depression: Effect on Blood Flow, Tissue Oxygenation, and Electroencephalogram

1994 • 297 citations

The Effect of MK-801 on Cortical Spreading Depression in the Penumbral Zone following Focal Ischaemia in the Rat

1992 • 290 citations

Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III

1987 • 288 citations

COMPOUNDS IN BRAIN EXTRACTS CAUSING SPREADING DEPRESSION OF CEREBRAL CORTICAL ACTIVITY AND CONTRACTION OF CRUSTACEAN MUSCLE

1959 • 270 citations

Induction of Spreading Depression in the Ischemic Hemisphere following Experimental Middle Cerebral Artery Occlusion: Effect on Infarct Morphology

1996 • 251 citations

The role of spreading depression in focal ischemia evaluated bv dffusion mapping

1996 • 242 citations

Temperature Modulation of Cerebral Depolarization during Focal Cerebral Ischemia in Rats: Correlation with Ischemic Injury

1993 • 201 citations

MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia

1994 • 196 citations

Glutamate release from the retina during spreading depression

1970 • 146 citations

In vivo Models of Cerebral Ischemia: Effects of Parenterally Administered NMDA Receptor Glycine Site Antagonists

1995 • 117 citations

Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model

1995 • 115 citations

Photothrombotic Infarction Triggers Multiple Episodes of Cortical Spreading Depression in Distant Brain Regions

1994 • 111 citations

NMDA‐receptor blockers but not NBQX, an AMPA‐receptor antagonist, inhibit spreading depression in the rat brain

1992 • 107 citations

Glycine Site Antagonist Attenuates Infarct Size in Experimental Focal Ischemia

1997 • 61 citations

A study of the dose dependency of a glycine receptor antagonist in focal ischemia.

1993 • 54 citations

The Neuroprotective Effect of the Glycine Site Antagonist 3R-(+)-cis-4-Methyl-HA966 (L-687,414) in a Rat Model of Focal Ischaemia

1995 • 48 citations

Glycine is required for NMDA receptor activation: electrophysiological evidence from intact rat hippocampus

1992 • 36 citations

Synthesis and study of the potential antiallergic activity of some pyrazole derivatives

1981 • 32 citations

Effects of glycine receptor antagonism on spreading depression in the rat

1994 • 24 citations