Regulation of Brain Nicotinic Receptors by Chronic Agonist Infusion

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Muscarinic Cholinergic Binding in Rat Brain

1974 • 1,214 citations

Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin

1985 • 1,037 citations

Evidence that Tobacco Smoking Increases the Density of (−)‐[³H]Nicotine Binding Sites in Human Brain

1988 • 554 citations

Nicotinic Cholinergic Receptor Binding Sites in the Brain: Regulation in Vivo

1983 • 478 citations

The paradox of nicotinic acetylcholine receptor upregulation by nicotine

1990 • 350 citations

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.

1980 • 342 citations

Stereospecific Nicotine Receptors on Rat Brain Membranes

1980 • 319 citations

Characterization of nicotine binding in mouse brain and comparison with the binding of alpha-bungarotoxin and quinuclidinyl benzilate.

1982 • 305 citations

Purification and characterization of a nicotinic acetylcholine receptor from rat brain.

1987 • 300 citations

Receptor Adaptations to Centrally Acting Drugs

1981 • 293 citations

In Vivo Regulation of [³H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs

1985 • 283 citations

Nicotinic binding sites in rat and mouse brain: comparison of acetylcholine, nicotine, and alpha-bungarotoxin.

1986 • 262 citations

Nicotinic cholinergic receptors labeled by [3H]acetylcholine in rat brain.

1982 • 259 citations

Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles.

1983 • 191 citations

Altered [3H]quinuclidinyl benzilate binding in the striatum of rats following chronic cholinesterase inhibition with diisopropylfluorophosphate.

1980 • 170 citations

Nicotine receptors in the mammalian brain

1990 • 149 citations

Stimulation of mouse heart and liver microsomal lipid peroxidation by anthracycline anticancer drugs: characterization and effects of reactive oxygen scavengers.

1983 • 138 citations

Smoking-induced changes in nicotine disposition: Application of a new HPLC assay for nicotine and its metabolites

1982 • 127 citations

Presynaptic Nicotinic Receptors and the Modulation of Transmitter Release

2007 • 126 citations

Administration of an organophosphate causes a decrease in muscarinic receptor levels in rat brain

1979 • 122 citations

[3H]Nicotine binding in rat brain: alteration after chronic acetylcholinesterase inhibition.

1983 • 118 citations

Receptor alterations and drug tolerance

1979 • 117 citations

Effect of Chronic Nicotine Treatment on Nicotinic Autoreceptor Function and N-[³H]Methylcarbamylcholine Binding Sites in the Rat Brain

1989 • 111 citations

Relations between structure and nicotine‐like activity: X‐ray crystal structure analysis of (−)−cytisine and (−)−lobeline hydrochloride and a comparison with (−)−nicotine and other nicotine‐like compounds

1989 • 95 citations

An autoradiographic analysis of cholinergic receptors in mouse brain

1989 • 87 citations

Cataleptic state and hypothermia in mice, caused by central cholinergic stimulation and antagonized by anticholinergic and antidepressant drugs

1968 • 87 citations

α‐Bungarotoxin Binds to Low‐Affinity Nicotine Binding Sites in Rat Brain

1986 • 83 citations

Nicotine-induced tolerance and receptor changes in four mouse strains.

1986 • 82 citations

Dose-response analysis of nicotine tolerance and receptor changes in two inbred mouse strains.

1986 • 81 citations

Dissociation of the apparent relationship between nicotine tolerance and up-regulation of nicotinic receptors

1990 • 79 citations

Modulation of Nicotine Receptors by Chronic Exposure to Nicotinic Agonists and Antagonists

2007 • 73 citations

The comparative binding characteristics of nicotinic ligands and their pharmacology

1988 • 63 citations

Kinetics and mechanism of L-[3H]nicotine binding to putative high affinity receptor sites in rat brain.

1987 • 62 citations

Plasticity of neuronal receptors

1989 • 61 citations

Techniques for the chronic cannulation of the jugular vein in mice

1979 • 60 citations

Cholinergic adaptations to chronic oxotremorine infusion.

1981 • 51 citations

EFFECTS OF NICOTINE AND SOME NICOTINE‐LIKE COMPOUNDS INJECTED INTO THE CEREBRAL VENTRICLES OF THE CAT

1966 • 47 citations

Topographical distribution of down-regulated muscarinic receptors in rat brains after repeated exposure to diisopropyl phosphorofluoridate

1984 • 46 citations

Modulation of acetylcholine release by nicotinic receptors in the rat brain

1989 • 45 citations

Pharmacological differentiation of “nicotinic” and “muscarinic” catalepsy

1971 • 45 citations

Purification of L-[3H] nicotine eliminates low affinity binding

1990 • 38 citations

Selective changes in sensitivity to cholinergic agonists and receptor changes elicited by continuous physostigmine infusion.

1990 • 25 citations

An attempt to distinguish between the actions of neuromuscular blocking drugs on the acetylcholine receptor and on its associated ionic channel

1980 • 20 citations

Genetic influences on tolerance development with chronic oxotremorine infusion

1987 • 18 citations

Chapter 22 Primary cholinergic and indirect dopaminergic mediation of behavioural effects of nicotine

1989 • 17 citations

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