Imidacloprid, Thiacloprid, and Their Imine Derivatives Up-Regulate the α4β2 Nicotinic Acetylcholine Receptor in M10 Cells

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

1992 • 858 citations

Evidence that Tobacco Smoking Increases the Density of (−)‐[³H]Nicotine Binding Sites in Human Brain

1988 • 554 citations

Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

1992 • 540 citations

Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.

1994 • 381 citations

Epibatidine, a potent analgetic and nicotinic agonist.

1994 • 371 citations

Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor

1999 • 341 citations

In Vivo Regulation of [³H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs

1985 • 283 citations

Time course study of the effects of chronic nicotine infusion on drug response and brain receptors.

1985 • 271 citations

Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies

1988 • 241 citations

Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine.

1999 • 238 citations

Phosphorylation of ligand‐gated ion channels: a possible mode of synaptic plasticity

1992 • 231 citations

Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts.

1991 • 196 citations

Upregulation of Surface α4β2 Nicotinic Receptors Is Initiated by Receptor Desensitization after Chronic Exposure to Nicotine

1999 • 194 citations

Chronic Nicotine Treatment Up-Regulates α3 and α7 Acetylcholine Receptor Subtypes Expressed by the Human Neuroblastoma Cell Line SH-SY5Y

1997 • 184 citations

An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment.

1991 • 152 citations

Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.

1998 • 150 citations

Structural factors contributing to insecticidal and selective actions of neonicotinoids

1998 • 147 citations

Minor structural changes in nicotinoid insecticides confer differential subtype selectivity for mammalian nicotinic acetylcholine receptors

1999 • 144 citations

Regulation of Human α4β2 Neuronal Nicotinic Acetylcholine Receptors by Cholinergic Channel Ligands and Second Messenger Pathways

1997 • 131 citations

Effects of the α subunit on imidacloprid sensitivity of recombinant nicotinic acetylcholine receptors

1998 • 131 citations

Pharmacological properties of immuno-isolated neuronal nicotinic receptors

1986 • 127 citations

Chloronicotinyl insecticides-discovery, application and future perspective

1997 • 126 citations

Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels.

1996 • 126 citations

Mechanisms of up-regulation of neuronal nicotinic acetylcholine receptors in clonal cell lines and primary cultures of fetal rat brain.

1995 • 117 citations

Novel and Potent 6-Chloro-3-pyridinyl Ligands for the α4β2 Neuronal Nicotinic Acetylcholine Receptor

1999 • 54 citations

Post-translational regulation of neuronal acetylcholine receptors stably expressed in a mouse fibroblast cell line

1996 • 35 citations

Phosphorylation of rat brain nicotinic acetylcholine receptor by cAMP-dependent protein kinase in vitro

1993 • 34 citations

Imidacloprid: Toxicology and Metabolism

1999 • 32 citations