Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples

1978 • 6,494 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

1994 • 869 citations

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

1992 • 858 citations

Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

1992 • 540 citations

Effect of smoking history on [3H]nicotine binding in human postmortem brain.

1997 • 382 citations

Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.

1994 • 381 citations

The paradox of nicotinic acetylcholine receptor upregulation by nicotine

1990 • 350 citations

Neurons Can Maintain Multiple Classes of Nicotinic Acetylcholine Receptors Distinguished by Different Subunit Compositions

1995 • 293 citations

Receptor Adaptations to Centrally Acting Drugs

1981 • 293 citations

Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors.

1995 • 284 citations

In Vivo Regulation of [³H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs

1985 • 283 citations

Time course study of the effects of chronic nicotine infusion on drug response and brain receptors.

1985 • 271 citations

Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts.

1991 • 196 citations

Characterization of (+/-)(-)[3H]epibatidine binding to nicotinic cholinergic receptors in rat and human brain.

1995 • 194 citations

Chronic Nicotine Treatment Up-Regulates α3 and α7 Acetylcholine Receptor Subtypes Expressed by the Human Neuroblastoma Cell Line SH-SY5Y

1997 • 184 citations

Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.

1996 • 172 citations

Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes.

1990 • 157 citations

An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment.

1991 • 152 citations

Regulation of Human α4β2 Neuronal Nicotinic Acetylcholine Receptors by Cholinergic Channel Ligands and Second Messenger Pathways

1997 • 131 citations

(+)‐Anatoxin‐a Is a Potent Agonist at Neuronal Nicotinic Acetylcholine Receptors

1993 • 131 citations

Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels.

1996 • 126 citations

Dose‐Response Relationship for Nicotine‐Induced Up‐Regulation of Rat Brain Nicotinic Receptors

1997 • 120 citations

Mechanisms of up-regulation of neuronal nicotinic acetylcholine receptors in clonal cell lines and primary cultures of fetal rat brain.

1995 • 117 citations

Upregulation of nicotinic receptors following continuous infusion of nicotine is brain-region-specific

1993 • 105 citations

α-Bungarotoxin binding sites in rat hippocampal and cortical cultures: initial characterisation, colocalisation with α7 subunits and up-regulation by chronic nicotine treatment

1995 • 103 citations

Relationship between up-regulation of nicotine binding sites in rat brain and delayed cognitive enhancement observed after chronic or acute nicotinic receptor stimulation

1996 • 86 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. III. Agonist actions of the novel alkaloid epibatidine and analysis of type II current.

1995 • 82 citations

Neuronal acetylcholine receptors: fate of surface and internal pools in cell culture

1987 • 79 citations

Kinetics and mechanism of L-[3H]nicotine binding to putative high affinity receptor sites in rat brain.

1987 • 62 citations

Nicotinic agonists differ in activation and desensitization of 86Rb+ efflux from mouse thalamic synaptosomes.

1996 • 60 citations

Desensitization of Nicotine‐Stimulated ⁸⁶Rb⁺ Efflux from Mouse Brain Synaptosomes

1994 • 58 citations

Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed inXenopus laevis oocytes

1995 • 49 citations

Blockade of nicotinic receptor‐mediated release of dopamine from striatal synaptosomes by chlorisondamine administeredin vivo

1994 • 48 citations

Chronic GABA treatment downregulates the GABA A receptor α2 and α3 subunit mRNAS as well as polypeptide expression in primary cultured cerebral cortical neurons

1994 • 44 citations

Immunocytochemical localization of nicotinic acetylcholine receptor in rat cerebral cortex

1995 • 41 citations

Tacrine interacts with an allosteric activator site on α4β2 nAChRs in M10 cells

1996 • 37 citations

Post-translational regulation of neuronal acetylcholine receptors stably expressed in a mouse fibroblast cell line

1996 • 35 citations

Regulation of α4β2 nicotinic acetylcholine receptors in M10 cells following treatment with nicotinic agents

1995 • 35 citations

Comparison of the binding of nicotinic agonists to receptors from human and rat cerebral cortex and from chick brain (α4β2) transfected into mouse fibroblasts with ion channel activity

1994 • 30 citations

General Principles of Receptor Binding

2003 • 17 citations

Differential upregulation of α7 and α3 subunit-containing nicotinic acetylcholine receptors in rat hippocampal and PC12 cell cultures

1997 • 6 citations