Interleukin 6 acts as a paracrine growth factor in human mammary carcinoma cell lines.

The biology of interleukin-6

1989 • 1,964 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).

1985 • 679 citations

Interleukin‐6 (IL‐6) functions as an in vitro autocrine growth factor in renal cell carcinomas

1989 • 420 citations

Molecular Cloning and Expression of Rat Interleukin-1α cDNA

1989 • 332 citations

INTERLEUKIN-6 STIMULATES ANTERIOR PITUITARY HORMONE RELEASEIN VITRO.

1989 • 323 citations

Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures.

1990 • 226 citations

The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6

1988 • 198 citations

Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2.

1988 • 182 citations

Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.

1989 • 179 citations

Growth Dominance of the Metastatic Cancer Cell: Cellular and Molecular Aspects

1990 • 179 citations

Interleukin 6 decreases cell-cell association and increases motility of ductal breast carcinoma cells.

1989 • 158 citations

Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.

1990 • 154 citations

Purification and Characterization of Soluble Human IL-6 Receptor Expressed in CHO Cells

1990 • 151 citations

Interleukin-6 immunoreactivity in human tumors.

1989 • 136 citations

Enhanced Expression of Interleukin-6 in Primary Human Renal Cell Carcinomas

1991 • 133 citations

Strong association between c-myb and oestrogen-receptor expression in human breast cancer.

1990 • 130 citations

Expression and function of interleukin‐6 in epithelial cells

1991 • 109 citations

Interleukin 6 is secreted by breast fibroblasts and stimulates 17β‐oestradiol oxidoreductase activity of MCF‐7 cells: Possible paracrine regulation of breast 17β‐oestradiol levels

1991 • 77 citations

Differential expression of multiple MDM2 messenger RNAs and proteins in normal and tumorigenic breast epithelial cells.

1995 • 74 citations

Interleukin-1 alpha and interleukin-6 act additively to inhibit growth of MCF-7 breast cancer cells in vitro.

1993 • 70 citations

Regulation of ICAM‐1 (CD54) expression in human breast cancer cell lines by interleukin 6 and fibroblast‐derived factors

1994 • 67 citations

The evidence for interleukin-6 as an autocrine growth factor in malignancy.

1992 • 40 citations

IL-6 receptors and sensitivity to growth inhibition by IL-6 in clones of human breast carcinoma cells.

1991 • 35 citations

Interleukin-1 is a motility factor for human breast carcinoma cells in vitro: additive effect with interleukin-6.

1992 • 32 citations

Autoregulation of interleukin 6 and granulocyte-macrophage colony-stimulating factor in the differentiation of myeloid leukemic cells.

1989 • 30 citations

Coexpression of the genes for interleukin 6 and its receptor without apparent involvement in the proliferation of acute myeloid leukemia cells.

1991 • 28 citations

Growth-stimulating activity of interleukin 6 on human mammary epithelial cells transfected with the int-2 gene.

1993 • 24 citations