Epithelial-Specific and Stage-Specific Functions of Insulin-Like Growth Factor-I during Postnatal Mammary Development

Normal growth and development in the absence of hepatic insulin-like growth factor I

1999 • 1,430 citations

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

1999 • 938 citations

Cre-mediated gene deletion in the mammary gland

1997 • 504 citations

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes

2003 • 351 citations

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.

1989 • 334 citations

Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17 beta-estradiol.

1988 • 330 citations

Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation

1995 • 285 citations

Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice.

2001 • 284 citations

Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.

1989 • 233 citations

Insulin-Like Growth Factor I Is Essential for Postnatal Growth in Response to Growth Hormone

1999 • 230 citations

Insulin-Like Growth Factor I Is Essential for Terminal End Bud Formation and Ductal Morphogenesis during Mammary Development1

1999 • 226 citations

Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development

2002 • 205 citations

Insulin-Like Growth Factor-I Affects Perinatal Lethality and Postnatal Development in a Gene Dosage-Dependent Manner: Manipulation Using the Cre/loxP System in Transgenic Mice

1998 • 185 citations

Postnatal mammary gland morphogenesis

2001 • 165 citations

Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle

2002 • 132 citations

Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.

1996 • 131 citations

Targeted Disruption of the IGF-I Receptor Gene Decreases Cellular Proliferation in Mammary Terminal End Buds

2001 • 129 citations

Conditional Knockout of Mouse Insulin-Like Growth Factor-1 Gene Using the Cre/loxP System

2000 • 129 citations

Evidence That the Mammary Fat Pad Mediates the Action of Growth Hormone in Mammary Gland Development

1998 • 119 citations

Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development.

1992 • 114 citations

Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1

1992 • 114 citations

Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle

2002 • 105 citations

NON-LACTOGENIC EFFECTS OF GROWTH HORMONE ON GROWTH AND INSULIN-LIKE GROWTH FACTOR-I MESSENGER RIBONUCLEIC ACID OF RAT MAMMARY GLAND

1990 • 105 citations

Mammary Gland Branching Morphogenesis Is Diminished in Mice with a Deficiency of Insulin-like Growth Factor-I (IGF-I), But Not in Mice with a Liver-Specific Deletion of IGF-I

2004 • 89 citations

Progesterone Stimulates Mammary Gland Ductal Morphogenesis by Synergizing with and Enhancing Insulin-Like Growth Factor-I Action

2004 • 88 citations

The Insulin-Like Growth Factors (IGF) and IGF Type I Receptor during Postnatal Growth of the Murine Mammary Gland: Sites of Messenger Ribonucleic Acid Expression and Potential Functions**This work was supported, in part, by NIH Grant DK-48103 (to T.L.W.)

1999 • 86 citations

The insulin-like growth factors (IGFs) and IGF binding proteins in postnatal development of murine mammary glands.

2000 • 82 citations

Pancreatic-Specific Inactivation of IGF-I Gene Causes Enlarged Pancreatic Islets and Significant Resistance to Diabetes

2004 • 75 citations

Insulin and Prolactin Synergistically Stimulate β-Casein Messenger Ribonucleic Acid Translation by Cytoplasmic Polyadenylation

2004 • 67 citations

Somatomedin-C Substitutes for Insulin for the Growth of Mammary Epithelial Cells from Normal Virgin Mice in Serum-Free Collagen Gel Cell Culture*

1986 • 60 citations

Maintenance of normal rat mammary epithelial cells by insulin and insulin-like growth factor 1

1988 • 56 citations

Requirement for IGF-I in Epidermal Growth Factor-Mediated Cell Cycle Progression of Mammary Epithelial Cells

2002 • 54 citations

Expression of the Insulin-Like Growth Factor Binding Proteins during Postnatal Development of the Murine Mammary Gland

2004 • 46 citations

Morphogenesis of Mammary Gland Development

2004 • 44 citations

Growth Factor Regulation of Cell Cycle Progression in Mammary Epithelial Cells

2004 • 39 citations

Endocrinology of breast cancer

1987 • 32 citations

Circulating IGF‐1 and Its Role in Cancer: Lessons from the IGF‐1 Gene Deletion (LID) Mouse

2004 • 22 citations

Expression and Regulation of Insulin-like Growth Factors and Their Binding Proteins in the Normal Breast

1999 • 8 citations