Multiple p21ras effector pathways regulate nuclear factor of activated T cells.

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells

1986 • 408 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK

1994 • 350 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).

1995 • 255 citations

Protein Synthesis Inhibitors Reveal Differential Regulation of Mitogen-Activated Protein Kinase and Stress-Activated Protein Kinase Pathways That Converge on Elk-1

1995 • 243 citations

The NFAT-1 DNA Binding Complex in Activated T Cells Contains Fra-1 and JunB

1993 • 215 citations

Analysis of the Role of Protein Kinase C-α, -ε, and -ζ in T Cell Activation

1995 • 184 citations

p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes.

1993 • 167 citations

p21ras mediates control of IL-2 gene promoter function in T cell activation.

1992 • 166 citations

The regulation and function of p21ras during T-cell activation and growth

1995 • 160 citations

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

1991 • 138 citations

The small GTPases Rac and Rho as regulators of secretion in mast cells

1995 • 137 citations

Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor.

1990 • 101 citations

Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.

1994 • 93 citations

Interleukin-2 promoter activation in T-cells expressing activated Ha-ras.

1992 • 60 citations

The role of Raf-1 in the regulation of extracellular signal-regulated kinase 2 by the T cell antigen receptor.

1994 • 59 citations

Protein kinase C is not a downstream effector of p21^ras in activated T cells

1995 • 26 citations

Two Dominant Inhibitory Mutants of p21^ras Interfere with Insulin-Induced Gene Expression

1991 • 24 citations