PSM, an Insulin-Dependent, Pro-Rich, PH, SH2 Domain Containing Partner of the Insulin Receptor

Protein modules and signalling networks

1995 • 2,447 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

1991 • 1,489 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Profile analysis: detection of distantly related proteins.

1987 • 1,308 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

Issues in searching molecular sequence databases

1994 • 781 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Recognition and specificity in protein tyrosine kinase-mediated signalling

1995 • 367 citations

A reappraisal of non-consensus mRNA splice sites

1991 • 324 citations

Insulin Signal Transduction and the IRS Proteins

1996 • 323 citations

Protein Tyrosine Phosphatase 1B Interacts With the Activated Insulin Receptor

1996 • 293 citations

Insulin Signalling and Insulin Actions in the Muscles and Livers of Insulin-Resistant, Insulin Receptor Substrate 1-Deficient Mice

1996 • 289 citations

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

1996 • 287 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice

1995 • 231 citations

Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase

1996 • 217 citations

Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells

1997 • 212 citations

Differential Effects of Constitutively Active Phosphatidylinositol 3-Kinase on Glucose Transport, Glycogen Synthase Activity, and DNA Synthesis in 3T3-L1 Adipocytes

1997 • 179 citations

Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.

1988 • 164 citations

Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.

1995 • 163 citations

The Yeast Tribrid System—Genetic Detection of trans-phosphorylated ITAM-SH2-Interactions

1995 • 157 citations

Binding of ZAP-70 to Phosphorylated T-Cell Receptor ζ and η Enhances Its Autophosphorylation and Generates Specific Binding Sites for SH2 Domain-Containing Proteins

1995 • 154 citations

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.

1995 • 149 citations

Diverse signaling pathways in the cellular actions of insulin

1996 • 144 citations

Interaction of a GRB-IR Splice Variant (a Human GRB10 Homolog) with the Insulin and Insulin-like Growth Factor I Receptors

1996 • 139 citations

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.

1994 • 138 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.

1994 • 126 citations

Protein kinase C group B members PKC-δ, -ɛ, -ζ and PKC-L(η). Comparison of properties of recombinant proteins in vitro and in vivo

1992 • 121 citations

The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.

1993 • 120 citations

Human GRB-IRβ/GRB10

1997 • 116 citations

Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling.

1994 • 109 citations

Hepatocyte plasma membrane ecto-ATPase (pp120HA4) is a substrate for tyrosine kinase activity of the insulin receptor

1990 • 108 citations

Effect of vanadate on the cellular accumulation of pp15, an apparent product of insulin receptor tyrosine kinase action.

1988 • 103 citations

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.

1997 • 101 citations

pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms.

1993 • 100 citations

Interaction between the Grb10 SH2 Domain and the Insulin Receptor Carboxyl Terminus

1996 • 100 citations

Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.

1994 • 94 citations

The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus

1991 • 90 citations

Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.

1994 • 88 citations

Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells.

1987 • 84 citations

Identification of phosphorylated 422(aP2) protein as pp15, the 15-kilodalton target of the insulin receptor tyrosine kinase in 3T3-L1 adipocytes.

1988 • 72 citations

Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation.

1996 • 68 citations

Interaction of SH2-containing protein tyrosine phosphatase 2 with the insulin receptor and the insulin-like growth factor-I receptor: studies of the domains involved using the yeast two-hybrid system.

1996 • 65 citations

A Dominant-Negative Mutant of mSOS1 Inhibits Insulin-Induced Ras Activation and Reveals Ras-Dependent and -Independent Insulin Signaling Pathways

1995 • 55 citations

Signal Transduction Pathways Leading to Insulin-Induced Early Gene Induction

1995 • 53 citations

Two Naturally Occurring Mutant Insulin Receptors Phosphorylate Insulin Receptor Substrate-1 (IRS-1) but Fail to Mediate the Biological Effects of Insulin

1996 • 51 citations

Insulin-induced egr-1 and c-fos Expression in 32D Cells Requires Insulin Receptor, Shc, and Mitogen-activated Protein Kinase, but Not Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase Activation

1996 • 51 citations

Roles of protein-tyrosine phosphatases in growth factor signalling

1996 • 47 citations

Insulin signal transduction pathways

1994 • 44 citations

Insulin-dependent Tyrosine Phosphorylation of the vav Proto-oncogene Product in Cells of Hematopoietic Origin

1995 • 28 citations

Insulin Receptor Substrate 1 Rescues Insulin Action in CHO Cells Expressing Mutant Insulin Receptors That Lack a Juxtamembrane NPXY Motif

1995 • 27 citations

Studies into the Identity of the Sites of Insulin-Stimulated Insulin Receptor Serine Phosphorylation. Characterization of Synthetic Peptide Substrates for the Insulin-Stimulated Insulin Receptor Serine Kinase

1995 • 12 citations

Role of PI 3-kinase and SH-PTP2 in insulin action.

1996 • 11 citations

Insulin signaling network -- waiting for Copernicus.

1996 • 11 citations

Reduced phosphorylation of mitogen-activated protein kinase kinase in response to insulin in cells with truncated C-terminal domain of insulin receptor.

1996 • 5 citations