Interaction between the Grb10 SH2 Domain and the Insulin Receptor Carboxyl Terminus

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

1991 • 1,489 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

The insulin receptor: structure, function, and signaling

1994 • 434 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

1993 • 384 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice

1995 • 231 citations

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

1994 • 200 citations

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system.

1994 • 170 citations

Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.

1988 • 164 citations

Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.

1995 • 163 citations

Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding

1993 • 162 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.

1992 • 148 citations

The Ret Receptor Protein Tyrosine Kinase Associates with the SH2-containing Adapter Protein Grb10

1995 • 140 citations

The cloning of Grb10 reveals a new family of SH2 domain proteins.

1995 • 130 citations

Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.

1994 • 126 citations

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.

1994 • 126 citations

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

1993 • 116 citations

Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor

1993 • 106 citations

The Insulin Receptor and Its Substrate: Molecular Determinants of Early Events in Insulin Action

1993 • 92 citations

The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus

1991 • 90 citations

Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.

1994 • 88 citations

Insulin Stimulates the Tyrosine Dephosphorylation of pp125 Focal Adhesion Kinase

1995 • 74 citations

Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells.

1994 • 69 citations

Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity

1987 • 66 citations

The GRB family of SH2 domain proteins

1994 • 48 citations

Cellular expression of mutant insulin receptors interferes with the rapid transcriptional response to both insulin and insulin-like growth factor I.

1991 • 33 citations

The insulin receptor and type I IGF receptor: Comparison of structure and function

1992 • 32 citations

Human Insulin Receptors Expressed in Insulin-Insensitive Mouse Fibroblasts Couple with Extant Cellular Effector Systems to Confer Insulin Sensitivity and Responsiveness*

1989 • 26 citations

Insulin inhibits nuclear phosphatase activity: requirement for the C-terminal domain of the insulin receptor.

1995 • 12 citations

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