Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

1999 • 1,532 citations

Twenty proteins containing a C-terminal SOCS box form five structural classes

1998 • 735 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1999 • 712 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

Negative Regulation of Cytokine Signaling Pathways

2000 • 607 citations

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

1999 • 428 citations

Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

2000 • 397 citations

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

2000 • 390 citations

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1998 • 290 citations

Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6

1996 • 279 citations

Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice

1999 • 269 citations

SOCS-3 Is Tyrosine Phosphorylated in Response to Interleukin-2 and Suppresses STAT5 Phosphorylation and Lymphocyte Proliferation

1999 • 267 citations

Cloning and Characterization of Novel CIS Family Genes

1997 • 259 citations

Suppressors of Cytokine Signaling Proteins Are Differentially Expressed in Th1 and Th2 Cells: Implications for Th Cell Lineage Commitment and Maintenance

2002 • 243 citations

Negative regulators of cytokine signal transduction

1999 • 224 citations

SOCS-1/SSI-1-Deficient NKT Cells Participate in Severe Hepatitis through Dysregulated Cross-Talk Inhibition of IFN-γ and IL-4 Signaling In Vivo

2001 • 185 citations

Cutting Edge: SOCS-1 Is a Potent Inhibitor of IL-4 Signal Transduction

1999 • 183 citations

Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducingSOCS-1gene expression

1999 • 173 citations

Control of B cell development by Ras-mediated activation of Raf

1997 • 152 citations

T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6

1997 • 133 citations

Negative regulation of cytokine signaling: STAT-induced STAT inhibitor

1999 • 128 citations

Impaired Interleukin 4 Signaling in T Helper Type 1 Cells

1998 • 94 citations

CD28 Costimulation Accelerates IL-4 Receptor Sensitivity and IL-4-Mediated Th2 Differentiation

1999 • 78 citations

Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.

1995 • 73 citations