Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes

Chapter 4 Preparation of Isolated Rat Liver Cells

1976 • 5,335 citations

Lysosomotropic agents

1974 • 1,887 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Preparation of rat liver cells

1973 • 1,137 citations

Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.

1975 • 916 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Inhibition by Insulin of Valine Turnover in Liver

1970 • 338 citations

Induction of autophagy by amino-acid deprivation in perfused rat liver

1977 • 323 citations

Protein Turnover and Lysosome Function

1978 • 279 citations

Influence of amino acid availability on protein turnover in perfused skeletal muscle

1978 • 277 citations

Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy.

1978 • 276 citations

Compartmentation of Free Valine and Its Relation to Protein Turnover in Perfused Rat Liver

1972 • 231 citations

Inhibition of protein degradation in isolated rat hepatocytes

1977 • 214 citations

Induction of amino acid transport in primary cultures of adult rat liver parenchymal cells by insulin.

1976 • 198 citations

Suppression of Protein Turnover by Amino Acids in the Perfused Rat Liver

1972 • 190 citations

Uptake and degradation of 125I-labelled asialo-fetuin by isolated rat hepatocytes

1977 • 189 citations

Ammonia inhibition of protein degradation in isolated rat hepatocytes

1976 • 172 citations

Degradation of receptor-bound human choriogonadotropin by murine Leydig tumor cells.

1978 • 165 citations

Incorporation of radioactive amino acids into protein in isolated rat hepatocytes

1976 • 124 citations

Adhesion of rat hepatocytes to collagen

1978 • 102 citations

Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes

1978 • 101 citations

Protein degradation in isolated rat hepatocytes is inhibited by ammonia

1975 • 99 citations

Cellular autophagocytosis induced by deprivation of serum and amino acids in HeLa cells.

1976 • 99 citations

Effects of aminooxyacetate on the metabolism of isolated liver cells

1974 • 98 citations

Specific inhibition by NH4Cl of autophagy-associated proteolysis in cultured fibroblasts

1978 • 94 citations

Intracellular protein degradation in growing, in density‐inhibited, and in serum‐restricted fibroblast cultures

1977 • 73 citations

Protein-catabolic state of isolated rat hepatocytes

1977 • 70 citations

Hormonal regulation of amino acid transport and gluconeogenesis in primary cultures of adult rat liver parenchymal cells

1976 • 55 citations

Responses of protein synthesis and degradation in growth control of WI‐38 cells

1977 • 52 citations

Inhibitor of protein degradation formed during incubation of isolated rat hepatocytes in a cell culture medium

1977 • 41 citations

Inhibition of cell spreading by lysosomotropic amines

1979 • 21 citations

Regulation of tyrosine transminase degradation in the isolated perfused rat liver by cycloheximide and insulin

1971 • 20 citations